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Stenotrophomonas,Mycobacterium, and Streptomyces in home dust and air: associations with moldiness and other home/family characteristics 总被引:1,自引:0,他引:1
E. Kettleson S. Kumar T. Reponen S. Vesper D. Méheust S. A. Grinshpun A. Adhikari 《Indoor air》2013,23(5):387-396
Respiratory illnesses have been linked to children's exposures to water‐damaged homes. Therefore, understanding the microbiome in water‐damaged homes is critical to preventing these illnesses. Few studies have quantified bacterial contamination, especially specific species, in water‐damaged homes. We collected air and dust samples in twenty‐one low‐mold homes and twenty‐one high‐mold homes. The concentrations of three bacteria/genera, Stenotrophomonas maltophilia, Streptomyces sp., and Mycobacterium sp., were measured in air and dust samples using quantitative PCR (QPCR). The concentrations of the bacteria measured in the air samples were not associated with any specific home characteristic based on multiple regression models. However, higher concentrations of S. maltophilia in the dust samples were associated with water damage, that is, with higher floor surface moisture and higher concentrations of moisture‐related mold species. The concentrations of Streptomyces and Mycobacterium sp. had similar patterns and may be partially determined by human and animal occupants and outdoor sources of these bacteria. 相似文献
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William A. Paradise Benjamin J. Vesper Ajay Goel Joshua D. Waltonen Kenneth W. Altman G. Kenneth Haines III James A. Radosevich 《International journal of molecular sciences》2010,11(7):2715-2745
The free radical nitric oxide (NO•) is known to play a dual role in human physiology and pathophysiology. At low levels, NO• can protect cells; however, at higher levels, NO• is a known cytotoxin, having been implicated in tumor angiogenesis and progression. While the majority of research devoted to understanding the role of NO• in cancer has to date been tissue-specific, we herein review underlying commonalities of NO• which may well exist among tumors arising from a variety of different sites. We also discuss the role of NO• in human physiology and pathophysiology, including the very important relationship between NO• and the glutathione-transferases, a class of protective enzymes involved in cellular protection. The emerging role of NO• in three main areas of epigenetics—DNA methylation, microRNAs, and histone modifications—is then discussed. Finally, we describe the recent development of a model cell line system in which human tumor cell lines were adapted to high NO• (HNO) levels. We anticipate that these HNO cell lines will serve as a useful tool in the ongoing efforts to better understand the role of NO• in cancer. 相似文献
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Billy Wu Michael A. Parkes Vladimir Yufit Luca De Benedetti Sven Veismann Christian Wirsching Felix Vesper Ricardo F. Martinez-Botas Andrew J. Marquis Gregory J. Offer Nigel P. Brandon 《International Journal of Hydrogen Energy》2014
The design and test of a 9.5 kWe proton exchange membrane fuel cell passively coupled with a 33 × 1500 F supercapacitor pack is presented. Experimental results showed that the system reduced dynamic loads on the fuel cell without the need for additional DC/DC converters. Fuel efficiency gains of approximately 5% were achieved by passive hybridisation in addition to addressing two main operational degradation mechanisms: no-load idling and rapid load cycling. 相似文献
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Mary Jo Vesper Steve Vesper David Kahane Rich Haugland 《生命科学仪器》2007,5(1):32-35
霉菌在地球生物进程中是一个必需成分,无处不在.它们不仅能危害健康,例如导致感染和过敏,还能毁坏农作物、污染食品和医药品.因此,及时地发现并消灭多数有问题的霉菌是相当重要的.通过霉菌特异性定量聚合酶链反应技术的最新发展及应用,现在可以准确地识别室内的霉菌,并且利用其较高的定量精度,可以建立用于确定不正常霉菌环境的预测模型. 相似文献
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Vesper BJ Altman KW Elseth KM Haines GK Pavlova SI Tao L Tarjan G Radosevich JA 《ChemMedChem》2008,3(4):552-559
Gastroesophageal reflux disease (GERD) affects both men and women worldwide, with the most common symptom of GERD being frequent heartburn. If left untreated, more serious diseases including esophagitis and/or esophageal cancer may result. GERD has been commonly held to be the result of gastric acid refluxing into the esophagus. Recent work, however, has shown that there are acid-producing cells in the upper aerodigestive tract. In addition, acid-producing bacteria located within the upper gastrointestinal tract and oral cavity may also be a contributing factor in the onset of GERD. Proton pump inhibitors (PPIs) are commonly prescribed for treating GERD; these drugs are designed to stop the production of gastric acid by shutting down the H(+)/K(+)-ATPase enzyme located in parietal cells. PPI treatment is systemic and therefore significantly different than traditional antacids. Although a popular treatment choice, PPIs exhibit substantial interpatient variability and commonly fail to provide a complete cure to the disease. Recent studies have shown that H(+)/K(+)-ATPases are expressed in tissues outside the stomach, and the effects of PPIs in these nongastric tissues have not been fully explored. Likewise, acid-producing bacteria containing proton pumps are present in both the oral cavity and esophagus, and PPI use may also adversely affect these bacteria. The use of PPI therapy is further complicated by the two philosophical approaches to treating this disease: to treat only symptoms or to treat continuously. The latter approach frequently results in unwanted side effects which may be due to the PPIs acting on nongastric tissues or the microbes which colonize the upper aerodigestive tract. 相似文献
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In addition to mold, indoor bioaerosols also contain bacterial components that may have implications for human health. Endotoxin is a cell wall component in Gram-negative bacteria present at varying levels indoors that has been found to have respiratory health implications. Streptomyces is a large genus of Gram-positive bacteria, and some species have been shown to produce inflammatory reactions in vitro and in vivo. The aim of this study was to determine predictors of streptomycetes levels in house dust and to compare the variation in streptomycetes levels with that in endotoxin levels. Dust was collected by floor vacuuming from 178 homes in the Cincinnati metropolitan area. Streptomycetes levels were measured by quantitative PCR, and endotoxin was assayed by the Limulus amebocyte lysate method. Associations between home characteristics and bacterial contaminants, expressed as concentration and load, were investigated through multiple regression analyses. The presence of two or more dogs was a strong predictor of both streptomycetes and endotoxin levels. Season of dust collection and levels of outdoor molds were predictors of streptomycetes but not endotoxin levels. In contrast, number of inhabitants was a significant predictor of endotoxin load only. Neither streptomycetes nor endotoxin levels were associated with metrics of moisture damage. 相似文献
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