General distributed economic framework for dynamic spectrum allocation

The emergence of novel radio techniques enables the application of advantageous revolutionary spectrum policies. An important body of research has appeared about possible frequency management schemes, but none of them proposes solutions that meet every related criteria. In this paper we present our work on dynamic spectrum allocation and pricing that offers a distributed mechanism design, well-suited to practical employment issues. Our model handles interference effects without any restricting assumptions, provides universal scalable and incentive-compatible allocation and pricing mechanisms. We provide both analytical and numerical evaluation of the proposed framework, and in either case we prove this latter to be a suitable approach to efficient and flexible spectrum utilization.     

Joint optimization of preventive maintenance and inventory control in a production line using simulation

This paper proposes an integrated method for preventive maintenance and inventory control of a production line, composed of n machines (n?≥?1) without intermediate buffers. The machines are subject to failures and an age-dependent preventive maintenance policy is used. Approximate analytical results are proposed for the one machine case. Simulation software is used to model and simulate the behaviour of the production line of n machines under various maintenance and inventory control strategies. A methodology combining the simulation and genetic algorithms is proposed jointly to optimize maintenance and inventory control policies. Results are compared with the analytical solutions.     

Catalytic effects of metals of the iron subgroup on the chlorination of titanium carbide to form nanostructural carbon

The effect of the reaction temperature and the metals of an iron subgroup on the thermo-chemical treatment of titanium carbide with a chlorine gas and their influence on the carbon structure obtained thereby was studied. Different analytical methods such as porosity measurements, X-ray diffraction spectrometry and a high-resolution electron microscopy revealed the catalytic behaviour of the above-mentioned metals, which appeared to support the formation of graphitised carbon at much lower temperatures compared to those needed for the ordinary thermo-chemical chlorination of titanium carbide.     

Blood and plasma selenium levels and GSH-Px activities in patients with arterial hypertension and chronic heart disease

Among the 57 monoclonal antibodies analyzed within the T-cell group of the Second International Swine CD Workshop, one mAb fell within cluster T14a that included the CD6 standard a38b2 (No. 175). The new mAb MIL8 (No. 082) and a38b2 both precipitated from activated T-cells a 150 kDa monomeric protein. Staining patterns on the various cell types were similar. There was no inhibition of binding of either mAb to peripheral blood T-cells with the opposite mAb. The new mAb, MIL8, reacts with a separate epitope on porcine wCD6.     

Artificial Antigen-Presenting Interfaces in the Service of Immunology

While the beneficial impact of modifying and/or targeting T lymphocytes is becoming increasingly accepted in the treatment of different diseases, the road towards cell-based immunotherapy is still long and winding. Major challenges that remain include, amongst others, the guidance and exquisite regulation of immune processes ex vivo. In part, this is due to the difficulties of simulating ex vivo the intimate cellular interactions that occur between T cells and antigen-presenting cells (APCs). The fate of T cells is not solely regulated by the presence of certain molecules on the surface of APCs but also by their density and spatial distribution on the micro- and nanometric scale. Moreover, mechanical properties of APCs and force-dependent conformational changes during the formation of an immunological synapse (IS; a highly organized supramolecular complex at the T cell APC interface), play a crucial role in T cell fate regulation. Various different technical means have been developed to create APC substitutes that are able to simulate ex vivo signals originating from naturally occurring APCs. Here, we review the performance of APC surrogates and discuss their contribution to understanding mechanisms underlying the ability of T cells to perform the “intelligent” mission of acquiring, processing and responding to environmental information.     

An electromagnetism metaheuristic for solving the Maximum Betweenness Problem

In this paper we present an electromagnetism (EM) metaheuristic for solving NP hard Maximum Betweenness Problem (MBP). A new encoding scheme with appropriate objective functions is implemented. Specific representation of the individuals enables the EM operators to explore the searching space in a way that achieves high quality solutions. An effective 1-swap based local search procedure improved by the specific caching technique is performed on each EM point. The algorithm is tested both on real and artificial instances from the literature. Experimental results show that the proposed EM approach achieves all previously known optimal solutions, except one, and achieves the best-known solutions or outperforms other approaches on all large-scale instances, except two. Provided statistical analysis indicates that the EM approach is significantly better than other approaches.     

Minimizing the makespan in the non-preemptive job-shop scheduling with limited machine availability

This paper addresses the makespan minimization in a job-shop environment where the machines are not available during the whole planning horizon. The disjunctive graph model is used to represent the schedules and the concept of blocks is generalized to include the unavailability periods of machines. To solve the problem, we develop a taboo thresholding heuristic that uses a new block-based neighborhood function. Some sufficient conditions to eliminate the evaluation of non-improving moves are proposed. Experiments performed on existing problem instances of the literature show the efficiency of the proposed heuristic.