全文获取类型
收费全文 | 296篇 |
免费 | 18篇 |
专业分类
电工技术 | 1篇 |
化学工业 | 94篇 |
金属工艺 | 6篇 |
机械仪表 | 9篇 |
建筑科学 | 6篇 |
能源动力 | 8篇 |
轻工业 | 60篇 |
无线电 | 20篇 |
一般工业技术 | 30篇 |
冶金工业 | 57篇 |
原子能技术 | 5篇 |
自动化技术 | 18篇 |
出版年
2024年 | 1篇 |
2022年 | 6篇 |
2021年 | 24篇 |
2020年 | 10篇 |
2019年 | 5篇 |
2018年 | 6篇 |
2017年 | 9篇 |
2016年 | 7篇 |
2015年 | 6篇 |
2014年 | 11篇 |
2013年 | 15篇 |
2012年 | 19篇 |
2011年 | 20篇 |
2010年 | 10篇 |
2009年 | 13篇 |
2008年 | 16篇 |
2007年 | 14篇 |
2006年 | 13篇 |
2005年 | 1篇 |
2004年 | 3篇 |
2003年 | 4篇 |
2002年 | 4篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1999年 | 4篇 |
1998年 | 21篇 |
1997年 | 13篇 |
1996年 | 14篇 |
1995年 | 7篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1973年 | 1篇 |
1967年 | 1篇 |
1958年 | 1篇 |
排序方式: 共有314条查询结果,搜索用时 250 毫秒
1.
Dr. Maria L. Di Paolo Dr. Michael S. Christodoulou Dr. Alessandra M. Calogero Dr. Luca Pinzi Prof. Giulio Rastelli Prof. Daniele Passarella Prof. Graziella Cappelletti Prof. Lisa Dalla Via 《ChemMedChem》2019,14(18):1641-1652
A series of 2-phenyloxazoles bearing an amide group at position 4 were designed and synthesized for evaluation as potential inhibitors of human recombinant monoamine oxidases (hrMAOs). Results of kinetics experiments demonstrated that all compounds behave as competitive MAO inhibitors, with good selectivity toward the MAO-B isoform. The most potent and selective derivatives are characterized by inhibition constant (Ki) values in the sub-micromolar range and a good selectivity index (Ki MAO-A/Ki MAO-B>50). Some derivatives were also found to be able to inhibit MAO activity in nerve growth factor (NGF)-differentiated PC12 cells, taken as a model of neuronal cells. In particular, 2-(2-hydroxyphenyl)-N-phenyloxazole-4-carboxamide (compound 4 a ) may be a promising new scaffold, exerting the highest selectivity and inhibitory effect toward MAOs in NGF-differentiated PC12 cell lysates, without compromising cell viability. Molecular docking analysis allowed a rationalization of the experimentally observed binding affinity and selectivity. 相似文献
2.
The authors report the design of a new current-mode A/D converter, based on a modified successive-approximations model, in 1.2 μm CMOS technology. The proposed circuit is characterised by good accuracy and fast dynamic performance, low power consumption and small occupation area. SPICE simulations allow the design approach to be validated and the electrical performance of the ADC to be predicted 相似文献
3.
Within the framework of the distinction between episodic and semantic memory, it has been argued that these two memory systems are organised in a hierarchical way. The hierarchical hypothesis assumes that episodic memory is a specific subsystem of semantic memory and therefore implies that episodic memory cannot exist without semantic memory. If this hypothesis is correct, it should be expected that patients with impaired semantic memory also have impaired episodic memory. In the present study, two experiments investigated the influence of semantic encoding on recognition memory performance in a population of 20 patients with Alzheimer's disease and 18 normal controls. Both experiments assessed recognition memory for semantically-related items. In Experiment 2, but not in Experiment 1, subjects were explicitly instructed to make a semantic association between the items. Alzheimer's disease patients were impaired, compared to the normal controls, on the recognition memory performance of both experiments. The ability to make a semantic association between two items was significantly and positively correlated with the subjects' performance on the recognition tasks. A further analysis showed that patients who were impaired on the semantic association task did significantly worse on the recognition task of Experiment 2 than normal controls and patients who were unimpaired on the semantic association task. These findings are discussed in the context of memory deficits in Alzheimer's disease, and are interpreted as supporting the view that episodic memory for an item is affected by the level of semantic awareness of that same item. 相似文献
4.
5.
N. Realdon M. Dal Zotto E. Ragazzi G. Dalla Fini 《Drug development and industrial pharmacy》1996,22(2):125-134
The release rate of a drug dissolved in the liquid phase of lipogels may be greatly affected by the type and concentration of gelling agent and by processing conditions and mechanical treatment of the ointment. These differences in release rate are reduced after application of mechanical stress comparable with the strain exerted on the ointment during application to the skin. Therefore, changes in the concentration of gelling agents used to achieve suitable consistency and manufacturing and packing processes that meet industrial and marketing requirements do not appear to exert a practical influence on drug availability after application to the skin. 相似文献
6.
B. E. Elizalde M. Dalla Rosa C. R. Lerici 《Journal of the American Oil Chemists' Society》1991,68(10):758-762
Maillard reaction volatile compounds (MRV), prepared by heating a glucose-glycine solution, were tested as antioxidants in
soybean oil (SBO) thermoxidation. The volatiles were transferred into the oil by stripping with a stream of Nitrogen and substituting
the atmosphere above the oil with air containing MRV. Standard accelerated oxidation was performed by heating the SBO. Peroxide
value measurement and headspace gas Chromatographic analysis were carried out on all the samples. The MRV antioxidant activity
was evaluated by determining the effect of the induction period and the kinetic rate constant of peroxide and oxidation volatiles
formation. The MRV showed a significant antioxidant activity. The effectiveness was variable depending on MRV transfer method
to the oil, and the Maillard reaction extent was related to the browning level of glucose/glycine solution. It was found that
the maximum effect of MRV prolonged about three times the induction period and reduced the kinetic rate constant by half in
relation to the control sample. MRV affects oxidative stability of soybean oil by lengthening the induction period as well
as by decreasing the rate of oxidation at the propagation state and reducing the formation of hexanal. 相似文献
7.
A simple modification to an existing current comparator is proposed, which enables a very low response time to be achieved with a minimal increase in circuit complexity. Circuit simulations allowed the design approach to be validated and the comparator performance to be compared to those of two other existing comparators 相似文献
8.
Abstract. For linear processes, semiparametric estimation of the memory parameter, based on the log‐periodogram and local Whittle estimators, has been exhaustively examined and their properties well established. However, except for some specific cases, little is known about the estimation of the memory parameter for nonlinear processes. The purpose of this paper is to provide the general conditions under which the local Whittle estimator of the memory parameter of a stationary process is consistent and to examine its rate of convergence. We show that these conditions are satisfied for linear processes and a wide class of nonlinear models, among others, signal plus noise processes, nonlinear transforms of a Gaussian process ξt and exponential generalized autoregressive, conditionally heteroscedastic (EGARCH) models. Special cases where the estimator satisfies the central limit theorem are discussed. The finite‐sample performance of the estimator is investigated in a small Monte Carlo study. 相似文献
9.
The relationship between chemical structure and reactivity for thermal hydroprocessing was studied for five gas oils derived from Alberta bitumens. Chemical structure was characterized by combining data from 1 H and 13 C nuclear magnetic resonance spectroscopy, class fractionation, and elemental analysis to calculate structural parameters. Thermal hydrotreating was performed in a continuous-flow stirred reactor at 420 and 440°C, 13.9 MPa hydrogen pressure, and 1.5 h1 LHSV. Conversion of the 343–525°C boiling fraction of the gas oils was correlated with the concentration of naphthenic methylene groups in the feed. Formation of methane and ethane was dependent on the degree of condensation of the aromatic rings in the feed oils. Thermal desulfurization was highly correlated with the amount of saturates in the feed, and the aromaticity of the resin fraction. Hydrogen consumption increased with the aromaticity of the gas oil… 相似文献
10.
One of the main problems in operational risk management is the lack of loss data, which affects the parameter estimates of the marginal distributions of the losses. The principal reason is that financial institutions only started to collect operational loss data a few years ago, due to the relatively recent definition of this type of risk. Considering this drawback, the employment of Bayesian methods and simulation tools could be a natural solution to the problem. The use of Bayesian methods allows us to integrate the scarce and, sometimes, inaccurate quantitative data collected by the bank with prior information provided by experts. An original proposal is a Bayesian approach for modelling operational risk and for calculating the capital required to cover the estimated risks. Besides this methodological innovation a computational scheme, based on Markov chain Monte Carlo simulations, is required. In particular, the application of the MCMC method to estimate the parameters of the marginals shows advantages in terms of a reduction of capital charge according to different choices of the marginal loss distributions. 相似文献