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1.
This study sought to examine patterns of changes of psychological stress symptoms in autologous bone marrow transplantation (ABMT) recipients. Forty-nine patients affected by solid tumors were assessed using the Symptom Questionnaire on admission to hospital (before high-dose chemotherapy and ABMT) and before discharge. Symptoms of anxiety and anger tended to decrease and relaxation of improve over time. Nevertheless, on admission to hospital 30-50% of the patients reported severe to moderate symptoms of anxiety and depression. Before discharge, the prevalence was still high (20-35%). The implications of these findings are discussed in terms of the need to monitor the evolution of emotional functioning of cancer patients undergoing ABMT. 相似文献
2.
Vincenzo Augugliaro Vittorio Loddo Ignacio Maldonado Raffaele Molinari 《Solar Energy》2005,79(4):402-408
The photocatalytic oxidation of a common antibiotic, the lincomycin was carried out in aqueous suspensions of polycrystalline TiO2 Degussa P25 irradiated by sunlight. In order to improve the performance of the lincomycin degradation a hybrid system consisting of a solar photoreactor with the photocatalyst in suspension coupled with a membrane module, used to confine both photocatalyst and pollutants in the reaction environment, was tested.A preliminary study was carried out in order to determine some kinetics parameters of the drug photodegradation. The influence of initial substrate concentration on the lincomycin photooxidation rate was investigated. The photooxidation rate follows a pseudo-first order kinetics with respect to the lincomycin concentration under the used experimental conditions. The presence of the membrane reactor allows the catalyst separation and to operate in continuous mode as the membranes rejection for lincomycin and its oxidation products was quite high. 相似文献
3.
Margaret Ottaviano Emilio Francesco Giunta Marianna Tortora Marcello Curvietto Laura Attademo Davide Bosso Cinzia Cardalesi Mario Rosanova Pietro De Placido Erica Pietroluongo Vittorio Riccio Brigitta Mucci Sara Parola Maria Grazia Vitale Giovannella Palmieri Bruno Daniele Ester Simeone 《International journal of molecular sciences》2021,22(7)
As widely acknowledged, 40–50% of all melanoma patients harbour an activating BRAF mutation (mostly BRAF V600E). The identification of the RAS–RAF–MEK–ERK (MAP kinase) signalling pathway and its targeting has represented a valuable milestone for the advanced and, more recently, for the completely resected stage III and IV melanoma therapy management. However, despite progress in BRAF-mutant melanoma treatment, the two different approaches approved so far for metastatic disease, immunotherapy and BRAF+MEK inhibitors, allow a 5-year survival of no more than 60%, and most patients relapse during treatment due to acquired mechanisms of resistance. Deep insight into BRAF gene biology is fundamental to describe the acquired resistance mechanisms (primary and secondary) and to understand the molecular pathways that are now being investigated in preclinical and clinical studies with the aim of improving outcomes in BRAF-mutant patients. 相似文献
4.
The conditions for obtaining recrystallization in more ordered modifications are described for an uniaxially oriented sample of isotactic polypropylene, annealed with fixed ends. These recrystallization conditions are related to the conditions of a lamination process. 相似文献
5.
Protecting privacy on the Web is becoming increasingly complicated because of the considerable amount of personal and sensitive information left by users in many locations during their Web browsing and the silent actions of third party sites that collect data, aggregate information and build personal profiles of Internet users in order to provide free and personalized services. On the other hand, most of people are unaware that their information may be collected online, and that, after their aggregation from multiple sources, could be used for secondary purposes, such as linked to allow identification, without user’s notice. 相似文献
6.
Building a software architecture that meets functional requirements is a quite consolidated activity, whereas keeping high quality attributes is still an open challenge. In this paper we introduce an optimization framework that supports the decision whether to buy software components or to build them in-house upon designing a software architecture. We devise a non-linear cost/quality optimization model based on decision variables indicating the set of architectural components to buy and to build in order to minimize the software cost while keeping satisfactory values of quality attributes. From this point of view, our tool can be ideally embedded into a Cost Benefit Analysis Method to provide decision support to software architects. The novelty of our approach consists in building costs and quality attributes on a common set of decision variables related to software development. We start from a special case of the framework where the quality constraints are related to the delivery time and the product reliability, and the model solution also devises the amount of unit testing to be performed on built components. We generalize the framework formulation to represent a broader class of architectural cost-minimization problems under quality constraints, and discuss advantages and limitations of such approach. 相似文献
7.
Degree-Optimal Routing for P2P Systems 总被引:1,自引:0,他引:1
Giovanni Chiola Gennaro Cordasco Luisa Gargano Mikael Hammar Alberto Negro Vittorio Scarano 《Theory of Computing Systems》2009,45(1):43-63
We define a family of Distributed Hash Table systems whose aim is to combine the routing efficiency of randomized networks—e.g.
optimal average path length O(log 2
n/δlog δ) with δ degree—with the programmability and startup efficiency of a uniform overlay—that is, a deterministic system in which the overlay network is transitive and greedy routing is optimal. It is known that Ω(log n) is a lower bound on the average path length for uniform overlays with O(log n) degree (Xu et al., IEEE J. Sel. Areas Commun. 22(1), 151–163, 2004).
Our work is inspired by neighbor-of-neighbor (NoN) routing, a recently introduced variation of greedy routing that allows us to achieve optimal average path length in randomized networks. The advantage of our proposal is that of allowing
the NoN technique to be implemented without adding any overhead to the corresponding deterministic network.
We propose a family of networks parameterized with a positive integer c which measures the amount of randomness that is used. By varying the value c, the system goes from the deterministic case (c=1) to an “almost uniform” system. Increasing c to relatively low values allows for routing with asymptotically optimal average path length while retaining most of the advantages
of a uniform system, such as easy programmability and quick bootstrap of the nodes entering the system.
We also provide a matching lower bound for the average path length of the routing schemes for any c.
This work was partially supported by the Italian FIRB project “WEB-MINDS” (Wide-scalE, Broadband MIddleware for Network Distributed
Services), . 相似文献
8.
Antonio Balena Marco Bianco Ferruccio Pisanello Massimo De Vittorio 《Advanced functional materials》2023,33(39):2211773
Two-Photon Lithography, thanks to its very high sub-diffraction resolution, has become the lithographic technique par excellence in applications requiring small feature sizes and complex 3D pattering. Despite this, the fabrication times required for extended structures remain much longer than those of other competing techniques (UV mask lithography, nanoimprinting, etc.). Its low throughput prevents its wide adoption in industrial applications. To increase it, over the years different solutions have been proposed, although their usage is difficult to generalize and may be limited depending on the specific application. A promising strategy to further increase the throughput of Two-Photon Lithography, opening a concrete window for its adoption in industry, lies in its combination with holography approaches: in this way it is possible to generate dozens of foci from a single laser beam, thus parallelizing the fabrication of periodic structures, or to engineer the intensity distribution on the writing plane in a complex way, obtaining 3D microstructures with a single exposure. Here, the fundamental concepts behind high-speed Two-Photon Lithography and its combination with holography are discussed, and the literary production of recent years that exploits such techniques is reviewed, and contextualized according to the topic covered. 相似文献
9.
From Images to Shape Models for Object Detection 总被引:2,自引:0,他引:2
Vittorio Ferrari Frederic Jurie Cordelia Schmid 《International Journal of Computer Vision》2010,87(3):284-303
We present an object class detection approach which fully integrates the complementary strengths offered by shape matchers.
Like an object detector, it can learn class models directly from images, and can localize novel instances in the presence
of intra-class variations, clutter, and scale changes. Like a shape matcher, it finds the boundaries of objects, rather than
just their bounding-boxes. This is achieved by a novel technique for learning a shape model of an object class given images of example instances. Furthermore, we also integrate Hough-style voting with a non-rigid point matching algorithm to localize
the model in cluttered images. As demonstrated by an extensive evaluation, our method can localize object boundaries accurately
and does not need segmented examples for training (only bounding-boxes). 相似文献
10.
Vittorio Ghini Stefano Ferretti Fabio PanzieriAuthor vitae 《Journal of Systems and Software》2011,84(11):1827-1851
This paper presents a distributed architecture for the provision of seamless and responsive mobile multimedia services. This architecture allows its user applications to use concurrently all the wireless network interface cards (NICs) a mobile terminal is equipped with. In particular, as mobile multimedia services are usually implemented using the UDP protocol, our architecture enables the transmission of each UDP datagram through the “most suitable” (e.g. most responsive, least loaded) NIC among those available at the time a datagram is transmitted. We term this operating mode of our architecture Always Best Packet Switching (ABPS). ABPS enables the use of policies for load balancing and recovery purposes. In essence, the architecture we propose consists of the following two principal components: (i) a fixed proxy server, which acts as a relay for the mobile node and enables communications from/to this node regardless of possible firewalls and NAT systems, and (ii) a proxy client running in the mobile node responsible for maintaining a multi-path tunnel, constructed out of all the node's NICs, with the above mentioned fixed proxy server. We show how the architecture supports multimedia applications based on the SIP and RTP/RTCP protocols, and avoids the typical delays introduced by the two way message/response handshake of the SIP signaling protocol. Experimental results originated from the implementation of a VoIP application on top of the architecture we propose show the effectiveness of our approach. 相似文献