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排序方式: 共有493条查询结果,搜索用时 15 毫秒
1.
Vincenzo Augugliaro Vittorio Loddo Ignacio Maldonado Raffaele Molinari 《Solar Energy》2005,79(4):402-408
The photocatalytic oxidation of a common antibiotic, the lincomycin was carried out in aqueous suspensions of polycrystalline TiO2 Degussa P25 irradiated by sunlight. In order to improve the performance of the lincomycin degradation a hybrid system consisting of a solar photoreactor with the photocatalyst in suspension coupled with a membrane module, used to confine both photocatalyst and pollutants in the reaction environment, was tested.A preliminary study was carried out in order to determine some kinetics parameters of the drug photodegradation. The influence of initial substrate concentration on the lincomycin photooxidation rate was investigated. The photooxidation rate follows a pseudo-first order kinetics with respect to the lincomycin concentration under the used experimental conditions. The presence of the membrane reactor allows the catalyst separation and to operate in continuous mode as the membranes rejection for lincomycin and its oxidation products was quite high. 相似文献
2.
Margaret Ottaviano Emilio Francesco Giunta Marianna Tortora Marcello Curvietto Laura Attademo Davide Bosso Cinzia Cardalesi Mario Rosanova Pietro De Placido Erica Pietroluongo Vittorio Riccio Brigitta Mucci Sara Parola Maria Grazia Vitale Giovannella Palmieri Bruno Daniele Ester Simeone 《International journal of molecular sciences》2021,22(7)
As widely acknowledged, 40–50% of all melanoma patients harbour an activating BRAF mutation (mostly BRAF V600E). The identification of the RAS–RAF–MEK–ERK (MAP kinase) signalling pathway and its targeting has represented a valuable milestone for the advanced and, more recently, for the completely resected stage III and IV melanoma therapy management. However, despite progress in BRAF-mutant melanoma treatment, the two different approaches approved so far for metastatic disease, immunotherapy and BRAF+MEK inhibitors, allow a 5-year survival of no more than 60%, and most patients relapse during treatment due to acquired mechanisms of resistance. Deep insight into BRAF gene biology is fundamental to describe the acquired resistance mechanisms (primary and secondary) and to understand the molecular pathways that are now being investigated in preclinical and clinical studies with the aim of improving outcomes in BRAF-mutant patients. 相似文献
3.
The conditions for obtaining recrystallization in more ordered modifications are described for an uniaxially oriented sample of isotactic polypropylene, annealed with fixed ends. These recrystallization conditions are related to the conditions of a lamination process. 相似文献
4.
Building a software architecture that meets functional requirements is a quite consolidated activity, whereas keeping high quality attributes is still an open challenge. In this paper we introduce an optimization framework that supports the decision whether to buy software components or to build them in-house upon designing a software architecture. We devise a non-linear cost/quality optimization model based on decision variables indicating the set of architectural components to buy and to build in order to minimize the software cost while keeping satisfactory values of quality attributes. From this point of view, our tool can be ideally embedded into a Cost Benefit Analysis Method to provide decision support to software architects. The novelty of our approach consists in building costs and quality attributes on a common set of decision variables related to software development. We start from a special case of the framework where the quality constraints are related to the delivery time and the product reliability, and the model solution also devises the amount of unit testing to be performed on built components. We generalize the framework formulation to represent a broader class of architectural cost-minimization problems under quality constraints, and discuss advantages and limitations of such approach. 相似文献
5.
Degree-Optimal Routing for P2P Systems 总被引:1,自引:0,他引:1
Giovanni Chiola Gennaro Cordasco Luisa Gargano Mikael Hammar Alberto Negro Vittorio Scarano 《Theory of Computing Systems》2009,45(1):43-63
We define a family of Distributed Hash Table systems whose aim is to combine the routing efficiency of randomized networks—e.g.
optimal average path length O(log 2
n/δlog δ) with δ degree—with the programmability and startup efficiency of a uniform overlay—that is, a deterministic system in which the overlay network is transitive and greedy routing is optimal. It is known that Ω(log n) is a lower bound on the average path length for uniform overlays with O(log n) degree (Xu et al., IEEE J. Sel. Areas Commun. 22(1), 151–163, 2004).
Our work is inspired by neighbor-of-neighbor (NoN) routing, a recently introduced variation of greedy routing that allows us to achieve optimal average path length in randomized networks. The advantage of our proposal is that of allowing
the NoN technique to be implemented without adding any overhead to the corresponding deterministic network.
We propose a family of networks parameterized with a positive integer c which measures the amount of randomness that is used. By varying the value c, the system goes from the deterministic case (c=1) to an “almost uniform” system. Increasing c to relatively low values allows for routing with asymptotically optimal average path length while retaining most of the advantages
of a uniform system, such as easy programmability and quick bootstrap of the nodes entering the system.
We also provide a matching lower bound for the average path length of the routing schemes for any c.
This work was partially supported by the Italian FIRB project “WEB-MINDS” (Wide-scalE, Broadband MIddleware for Network Distributed
Services), . 相似文献
6.
Antonio Balena Marco Bianco Ferruccio Pisanello Massimo De Vittorio 《Advanced functional materials》2023,33(39):2211773
Two-Photon Lithography, thanks to its very high sub-diffraction resolution, has become the lithographic technique par excellence in applications requiring small feature sizes and complex 3D pattering. Despite this, the fabrication times required for extended structures remain much longer than those of other competing techniques (UV mask lithography, nanoimprinting, etc.). Its low throughput prevents its wide adoption in industrial applications. To increase it, over the years different solutions have been proposed, although their usage is difficult to generalize and may be limited depending on the specific application. A promising strategy to further increase the throughput of Two-Photon Lithography, opening a concrete window for its adoption in industry, lies in its combination with holography approaches: in this way it is possible to generate dozens of foci from a single laser beam, thus parallelizing the fabrication of periodic structures, or to engineer the intensity distribution on the writing plane in a complex way, obtaining 3D microstructures with a single exposure. Here, the fundamental concepts behind high-speed Two-Photon Lithography and its combination with holography are discussed, and the literary production of recent years that exploits such techniques is reviewed, and contextualized according to the topic covered. 相似文献
7.
From Images to Shape Models for Object Detection 总被引:2,自引:0,他引:2
Vittorio Ferrari Frederic Jurie Cordelia Schmid 《International Journal of Computer Vision》2010,87(3):284-303
We present an object class detection approach which fully integrates the complementary strengths offered by shape matchers.
Like an object detector, it can learn class models directly from images, and can localize novel instances in the presence
of intra-class variations, clutter, and scale changes. Like a shape matcher, it finds the boundaries of objects, rather than
just their bounding-boxes. This is achieved by a novel technique for learning a shape model of an object class given images of example instances. Furthermore, we also integrate Hough-style voting with a non-rigid point matching algorithm to localize
the model in cluttered images. As demonstrated by an extensive evaluation, our method can localize object boundaries accurately
and does not need segmented examples for training (only bounding-boxes). 相似文献
8.
Motivated by the increasing interest of the Computer Science community in the study and understanding of non-cooperative systems, we present a novel model for formalizing the rational behavior of agents with a more farsighted view of the consequences of their actions. This approach yields a framework creating new equilibria, which we call Second Order equilibria, starting from a ground set of traditional ones. By applying our approach to pure Nash equilibria, we define the set of Second Order pure Nash equilibria and present their applications to the Prisoner’s Dilemma game, to an instance of Braess’s Paradox in the Wardrop model and to the KP model with identical machines. 相似文献
9.
Binding Properties of RNA Quadruplex of SARS-CoV-2 to Berberine Compared to Telomeric DNA Quadruplex
Rosario Oliva Sanjib Mukherjee Magiliny Manisegaran Marco Campanile Pompea Del Vecchio Luigi Petraccone Roland Winter 《International journal of molecular sciences》2022,23(10)
Previous studies suggest that berberine, an isoquinoline alkaloid, has antiviral potential and is a possible therapeutic candidate against SARS-CoV-2. The molecular underpinnings of its action are still unknown. Potential targets include quadruplexes (G4Q) in the viral genome as they play a key role in modulating the biological activity of viruses. While several DNA-G4Q structures and their binding properties have been elucidated, RNA-G4Qs such as RG-1 of the N-gene of SARS-CoV-2 are less explored. Using biophysical techniques, the berberine binding thermodynamics and the associated conformational and hydration changes of RG-1 could be characterized and compared with human telomeric DNA-G4Q 22AG. Berberine can interact with both quadruplexes. Substantial changes were observed in the interaction of berberine with 22AG and RG-1, which adopt different topologies that can also change upon ligand binding. The strength of interaction and the thermodynamic signatures were found to dependent not only on the initial conformation of the quadruplex, but also on the type of salt present in solution. Since berberine has shown promise as a G-quadruplex stabilizer that can modulate viral gene expression, this study may also contribute to the development of optimized ligands that can discriminate between binding to DNA and RNA G-quadruplexes. 相似文献
10.
This essay examines a politically engaged research genre, which follows the biography of the author who founded two journals: one on mathematical models published in English (Quality and Quantity) and one on politically committed social and economic research published in Italian (Inchiesta). The research considered focuses on Italy in the 1950s, the research by Lazarsfeld in Vienna in the 1920s and in the United States in the 1950s and 1960s, and post-1968 politically committed research in Italy. The analysis of such politically committed types of research (all very different from one another in terms of the interpretative model of reality, the methods used and the relations with the tendering party and the people observed) allows one to understand how this kind of research can be performed with very different methods—all of which do, however, seek to modify reality on the grounds of the research results. The metaphor of the crystal and the flame presented by Italo Calvino in order to classify facts and ideas and styles and feelings can also be used to visualise the polarity (and the difficulty/impossibility of contact) that has always been present in sociology between two different tendencies: towards a discipline that offers the most abstract and objective interpretative model of reality possible with the use of mathematical models (the crystal), and, instead, towards a discipline in which an interpretative model of reality is central, one that produces a social change and in which the qualitative and quantitative methods utilised are at the service of this change (the flame). This polarity thus allows us to separate first and foremost all the politically committed research performed by others for different purposes (market research, research to verify some theoretical hypotheses, etc.) but the same polarity also lies within the politically committed research. We can, indeed, identify a type of politically committed research in an area that has, at one extreme, research tending towards the utmost objectivity and scientific quality of the results and where the co-ordinators try to have all the information on the subjects maintaining the greatest possible distance (the subjects must not know they are being observed); at the other extreme, there is a type of research in which the coordinator completely involves the subjects in the gathering of information that will serve to realise a piece of research whose political aims are explicitly shared. For the identification of a sufficiently articulated typology it has been important to consider five dimensions of politically committed research: (a) the characteristics of the research coordinator (his/her belonging to the type and the academic/non-academic professional status) and his/her interpretative model of reality (b) some general characteristics of the research (the tender and funding, the topic choice, the aims, the contributions to the sociological theory, the duration); (c) the research coordinators relations with the political actors (the intensity of the relations, the political use of the research); (d) the relations of the research co-ordinator with the research subjects; (e) the methodological choices (the basic strategies, the methods used, the use of mathematical procedures). The research that exemplifies this typology is all politically committed to the left and was realised in different times and contexts. I start by considering a kind of politically engaged research (co-research) that appeared in Italy in the 1950s; I then analyse two types of politically engaged research realised in Austria at the end of the 1920s and one in the United States in the 1950s; there then follow two kinds of research realised in the 1960s and 1970s in the United States and a further two kinds realised in Italy in the 1970s and early 1980s. In order to have other kinds of research please refer to the two Journals of which I am the editor: one is an English language journal of mathematical models (Quality and Quantity, International Journal of Methodology, founded in 1966 and published today by Kluwer of Amsterdam), and a politically engaged review (Inchiesta, founded in 1971 and still published today by Dedalo of Bari). 相似文献