Terminally ill patients and volunteer support: Is it the right intervention?

Comments on the article by K. T. Herbst-Damm and J. A. Kulik (see record 2005-02260-012) entitled Volunteer support, marital status, and the survival times of terminally ill patients. Can a simple and low-cost intervention, such as a visit by a volunteer, extend the life of terminally ill patients? The answer, according to a study by Herbst-Damm and Kulik (2005), is yes. When it comes to quality of life, however, the effects of volunteer visits remain murky. Thus, it is critical that we look beyond effects on longevity and assess how such a program would influence quality of life. Extending the life of terminally ill patients might not always a blessing. Prolonging their life might even cause harm, as it can extend unwanted physical and mental suffering. It may also go against some patients' desire to hasten their death. Despite Herbst-Damm and Kulik's important findings, the current author remains unconvinced as to the merits of implementing volunteer visits as an intervention policy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Achievement of pencil-beam radiation from a TM01 modecircular waveguide source

A method employing appropriately placed parallel-metallic plates in the aperture of a TM₀₁ mode circular waveguide source so as to have it produce pencil-beam radiation is described and analyzed. Programmed computations, with experimental verification, are given for the case of a C-Band TM₀₁ source flared out to a conical horn so as to produce moderate (22 dBi) gain. Means of extending the method to achieve higher gains (40 dBi to 60 dBi) and to modify the plate arrangement so as to produce the same effect with a TE₀₁ mode are briefly outlined     

Induction of hapten-specific tolerance by interleukin 10 in vivo

Interleukin 10 (IL-10) is released during the induction phase of contact sensitivity and was shown in prior functional studies to convert epidermal Langerhans cells (LC) from potent inducers of primary immune responses to specifically tolerizing cells in vitro. To investigate whether IL-10 also subserves the function of a tolerizing agent in vivo ears of BALB/c or C3H mice were injected intradermally with 1-2 micrograms of recombinant mouse (rm)IL-10 8 h before epicutaneous application of 3% trinitrochlorobenzene (TNCB; a contact allergen). As a control, mice were injected with phosphate-buffered saline or IL-10 plus neutralizing amounts of anti-IL-10 mAb. 5 d later, mice were challenged with 1% TNCB on contralateral ears and ear swelling response was measured 24 h later. Whereas control-treated mice showed a normal ear swelling response to epicutaneous challenge (delta mm-2 = 25 +/- 5), ear swelling response of IL-10-treated animals was significantly inhibited (delta mm-2 = 3 +/- 2). Coinjection of IL-10-specific mAb together with rmIL-10 completely abrogated this effect. To differentiate between a state of nonresponsiveness and induction of tolerance by IL-10, mice initially treated with IL-10 and TNCB were resensitized with 3% TNCB in the absence of any treatment after 14 d of rest (group 1). Again mice were challenged 5 d later and ear swelling responses were tested. Whereas control mice treated with allergen alone (group 2) showed a good swelling response (delta mm-2 = 28 +/- 6), IL-10-treated mice (group 1) showed a minimal response towards application of allergen (delta mm-2 = 4 +/- 2). To show that anergy induction by IL-10 was antigen-specific, mice initially treated with IL-10 plus TNCB were exposed to 0.5% dinitrofluorobenzene (DNFB) 14 d later (group 1). After challenge with 0.1% DNFB, IL-10-treated mice showed an ear swelling response (delta mm-2 = 13 +/- 3; group 1) similar to that of control mice only sensitized with DNFB (delta mm-2 = 14 +/- 3; group 3). In an attempt to show the induction of antigen-specific tolerance in these mice in vitro, regional lymph nodes of mice initially treated with TNCB plus IL-10 (group 1) and control-treated mice (groups 2 and 3) were prepared and cultured in the presence of TNBS, dinitrobenzene sulfonate (DNBS), or medium to measure antigen-specific proliferation.(ABSTRACT TRUNCATED AT 400 WORDS)     

Adsorption mode of ethyl pyruvate on platinum: an in situ XANES study

The adsorption of ethyl pyruvate on Pt(111) has been studied by in situ XANES measurements in the presence and absence of hydrogen. Depending on the hydrogen and ethyl pyruvate pressure, the C and O K‐edge spectra exhibit distinctly different angular dependence. Without hydrogen ethyl pyruvate is oriented preferentially perpendicular to the surface, indicating bonding via the O lone pairs. In the presence of hydrogen the mean orientation is more tilted towards the surface. Likely, ethyl pyruvate also interacts with Pt via its π system under these conditions. The observed angle‐dependent shift of the energy of the π* and σ* resonances indicates the coexistence of differently adsorbed ethyl pyruvate species. The experimental findings demonstrate the importance of the in situ approach for unraveling the adsorption mode of ethyl pyruvate in the enantioselective hydrogenation over cinchona‐alkaloid‐modified Pt. This revised version was published online in July 2006 with corrections to the Cover Date.     

Regularizing Flows over Lie Groups

In this paper we discuss regularization of images that take their value in matrix Lie groups. We describe an image as a section in a principal bundle which is a fibre bundle where the fiber (the feature space) is a Lie group. Via the scalar product on the Lie algebra, we define a bi-invariant metric on the Lie-group manifold. Thus, the fiber becomes a Riemannian manifold with respect to this metric. The induced metric from the principal bundle to the image manifold is obtained by means of the bi-invariant metric. A functional over the space of sections, i.e., the image manifolds, is defined. The resulting equations of motion generate a flow which evolves the sections in the spatial-Lie-group manifold. We suggest two different approaches to treat this functional and the corresponding PDEs. In the first approach we derive a set of coupled PDEs for the local coordinates of the Lie-group manifold. In the second approach a coordinate-free framework is proposed where the PDE is defined directly with respect to the Lie-group elements. This is a parameterization-free method. The differences between these two methods are discussed. We exemplify this framework on the well-known orientation diffusion problem, namely, the unit-circle S ¹ which is identified with the group of rotations in two dimensions, SO(2). Regularization of the group of rotations in 3D and 4D, SO(3) and SO(4), respectively, is demonstrated as well.

Online dynamic graph drawing

This paper presents an algorithm for drawing a sequence of graphs online. The algorithm strives to maintain the global structure of the graph and thus the user's mental map, while allowing arbitrary modifications between consecutive layouts. The algorithm works online and uses various execution culling methods in order to reduce the layout time and handle large dynamic graphs. Techniques for representing graphs on the GPU allow a speedup by a factor of up to 17 compared to the CPU implementation. The scalability of the algorithm across GPU generations is demonstrated. Applications of the algorithm to the visualization of discussion threads in Internet sites and to the visualization of social networks are provided.     

Task Switching After Cerebellar Damage.

The authors of this study investigated task switching following cerebellar damage. The study group consisted of 7 children and adolescents (M age = 13.8 years) who underwent surgical removal of a benign posterior fossa tumor. They were tested at a sufficient interval after surgery (M lag = 6.13 years) for restoration of normal cognitive skills and intelligence. Although all showed normal learning of the task compared with control participants, when rapid behavioral changes were required (short preparation time), they exhibited behavioral rigidity manifested by enhanced switching cost. These results are in line with another study on serial reaction time with the same patients (A. Berger et al., in press). They have important implications for our understanding of the cognitive sequelae of early cerebellar damage as well as the involvement of the cerebellum in task switching. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Ferromagnetic shape memory flapper

A new method for propulsion using a Ni₂MnGa ferromagnetic shape memory flapper is introduced. We optically examine the magnetic field induced strain of pure shear by means of a state of the art generator that provides alternating magnetic fields of 7000 Oe at frequencies of up to 100 Hz. Preliminary measurements show local shear deformation of about 5%, which open new frontiers in propulsion mechanisms.