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排序方式: 共有474条查询结果,搜索用时 0 毫秒
1.
Xianfeng Chen Holly J. Corbett Sally R. Yukiko Anthony P. Raphael Emily J. Fairmaid Tarl W. Prow Lorena E. Brown Germain J. P. Fernando Mark A. F. Kendall 《Advanced functional materials》2011,21(3):464-473
Densely packed dry‐coated microprojections are shown to deliver vaccines to targeted locations within the skin that are rich in immune cells, thus inducing protective immune responses against a lethal virus challenge. Selectively limiting the antigen coating to the tips of the projections, which penetrate the skin, would significantly reduce the amount of vaccine required in immunization. In this paper a simple technique, dip‐coating the microprojections, is introduced to meet this goal. By increasing the coating solution viscosity, an otherwise strong capillary action is mitigated and the desired controlled coating length on projections is achieved. Following application to the skin, most of the coated vaccine material is rapidly released from the projections (82.6% in mass within 2 min) to the target locations within the skin strata and a potent immune response is induced when a conventional influenza vaccine (Fluvax) is tested in a mouse model. The utility of this coating approach to a variety of molecules representative of vaccines (e.g., chicken egg ovalbumin (OVA) protein, DNA, and fluorescent dyes) is demonstrated. These collective attributes, together with the simplicity of the approach, position the dip‐coating method for practical utility in large vaccination campaigns. 相似文献
2.
Saka M Iijima K Nishida M Koma Y Hasegawa N Sato K Kato Y 《Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan》2008,49(3):160-167
The effects of processing and cooking on the levels of pesticide residues in soybean samples were investigated for 14 pesticides in pre-harvest samples. On soaking, the transfer ratios (%, total pesticide residue amount in product/that in soybean) of soaked soybean were greater than 60% for most of the pesticides investigated. The transfer ratio of soymilk ranged from 37% to 92%, and that of tofu ranged from 7% to 63%. The processing factor (Pf, the concentration (mg/kg) of pesticide in product/that in soybean) of tofu ranged from 0.026 to 0.28. These values varied among pesticides. There was a high correlation between the log P(ow) and the transfer ratio of tofu. The test described here should be useful to obtain the transfer ratios of pesticide residues in processing and/or cooking steps. 相似文献
3.
4.
An oxathiolanone derivative of rutin could be produced in the stomach after the ingestion of rutin containing foods, and the oxathiolanone derivative could be hydrolysed to an oxathiolanone derivative of quercetin (quercetin-oxathiolanone) in the intestine. Quercetin-oxathiolanone as well as quercetin inhibited xanthine oxidase. Approximately 0.05 μM quercetin-oxathiolanone inhibited the activity by 50%, whereas 50% inhibition by quercetin was observed at approximately 0.4 μM. The results suggested that quercetin-oxathiolanone can be used as an effective inhibitor of xanthine oxidase and that the ingestion of rutin-rich foods may be useful to prevent the increase in the blood concentration of uric acid. 相似文献
5.
Satohiro Yoshida Tsunehiro Tanaka Tomoko Hanada Takeshi Hiraiwa Hiroyoshi Kanai Takuzo Funabiki 《Catalysis Letters》1992,12(1-3):277-285
XANES of vanadium and niobium oxide on silica or alumina have been analyzed quantitatively by a deconvolution technique. Based on the results for reference compounds, local structures of supported vanadium and niobium species were identified. The composition was estimated from difference spectra for the samples which consisted of two kinds of species. 相似文献
6.
Oikawa D Nakanishi T Nakamura Y Takahashi Y Yamamoto T Shiba N Tobisa M Takagi T Iwamoto H Tachibana T Furuse M 《Lipids》2003,38(6):609-614
This study investigated the influence of PUFA on the properties of mouse skin. Mice (3 wk old) were given free access to oils
high in linoleic acid, CLA, or DHA for 4 wk. At the end of the experiment, their skins were compared by both biochemical and
histological methods. No significant differences in lipid and collagen contents were detected among treatments, although the
FA composition in the skin was altered depending upon the FA composition of the supplemented oils. Electron microscopy revealed
that the subcutaneous tissue layers in the CLA and DHA groups were significantly thinner than that in the high linoleic acid
group, whereas no differences in the thickness of dermis layers were observed among the three groups. These results suggest
that skin properties in mice are readily modified by dietary FA sources within 4 wk of dietary oil supplementation. 相似文献
7.
Yoriko Tanaka Masahiro Furuta Koichi Kuriyama Ryosuke Kuwabara Yukiko Katsuki Takeshi Kondo Akira Fujishima Kensuke Honda 《Electrochimica acta》2011,(3):1172
Nitrogen-doped hydrogenated amorphous carbon thin films (a-C:N:H, N-doped DLC) were synthesized with microwave-assisted plasma-enhanced chemical vapor deposition widely used for DLC coating such as the inner surface of PET bottles. The electrochemical properties of N-doped DLC surfaces that can be useful in the application as an electrochemical sensor were investigated. N-doped DLC was easily fabricated using the vapor of nitrogen contained hydrocarbon as carbon and nitrogen source. A N/C ratio of resulting N-doped DLC films was 0.08 and atomic ratio of sp3/sp2-bonded carbons was 25/75. The electrical resistivity and optical gap were 0.695 Ω cm and 0.38 eV, respectively. N-doped DLC thin film was found to be an ideal polarizable electrode material with physical stability and chemical inertness. The film has a wide working potential range over 3 V, low double-layer capacitance, and high resistance to electrochemically induced corrosion in strong acid media, which were the same level as those for boron-doped diamond (BDD). The charge transfer rates for the inorganic redox species, Fe2+/3+ and Fe(CN)64−/3− at N-doped DLC were sufficiently high. The redox reaction of Ce2+/3+ with standard potential higher than H2O/O2 were observed due to the wider potential window. At N-doped DLC, the change of the kinetics of Fe(CN)63−/4− by surface oxidation is different from that at BDD. The rate of Fe(CN)63−/4− was not varied before and after oxidative treatment on N-doped DLC includes sp2 carbons, which indicates high durability of the electrochemical activity against surface oxidation. 相似文献
8.
Yukiko Hirano Ilde Guedes Marcus Grimsditch Chun-Keung Loong Nobuyoshi Wakabayashi Lynn A. Boatner 《Journal of the American Ceramic Society》2002,85(4):1001-1003
The room-temperature elastic constants of ErVO4 were considerably smaller than those of isostructural silicate and phosphate analogs. The generally "less-rigid" crystalline lattice and weaker metal-oxygen bond-strength in the RVO4 (R = rare earth elements) phases indicates that these materials are of interest for potential applications as an interphase component in toughened oxide ceramic composites. 相似文献
9.
d -Glucaric acid (GA) is the one of aldaric acids and is an important bio-based building block for polymers. In this study, poly(m-xylylene-acetyl glucaramide) and poly(p-xylylene-acetyl glucaramide) were synthesized from GA acetate and two kind of aromatic diamines by solution polymerization. The chemical structures of the polyamides were analyzed by nuclear magnetic resonance spectroscopy. The weight-average molecular weights ranged from 3.3 × 103 to 1.15 × 104 with a polydispersity of 1.6–1.9, depending on monomer ratio or monomer concentration in solution. The 10% decomposition temperature of the polymers was about 210 °C. Differential scanning calorimetry revealed that the polyamides exhibited no peaks attributed to crystallization or melting point, which indicated that the polyamides were amorphous. No crystalline pattern was observed in the X-ray diffractograms, supporting this result. Polarized optical microscopy observation revealed that the polyamides exhibited melting-like behavior at above 150 °C, which was attributed to glass-transition behavior. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47255. 相似文献
10.
Integration amongst various decision-making processes, such as planning, design, and operation is necessary to dynamic and flexible batch production. To achieve a batch production integration, utilization of common models used for various decision-making processes is an effective approach. From this point of view, a batch system common model as described by a Petri net is proposed. In this article, a fault diagnosis technique for batch processes is presented using information about fault propagation and the possibilities of integration of fault analysis and controller synthesis are discussed on the basis of the Petri net based common models. 相似文献