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排序方式: 共有286条查询结果,搜索用时 15 毫秒
1.
H Tohgi K Utsugisawa M Yoshimura Y Nagane M Mihara 《Canadian Metallurgical Quarterly》1998,791(1-2):186-190
2.
OBJECTIVE: To determine the distribution and severity of arterial lesions of intracranial and extracranial arteries in stroke patients in Chinese. METHODS: We studied 120 consecutive autopsy cases including 100 cases of stroke (50-80 years) and 20 cases of cancer as controls (50-80 years). Medium intracranial arteries and their primary branches, small intracerebral arteries, arterioles and extracranial carotid arteries (from 16 cases only) were examined with light microscopy. RESULTS: The stroke patients had significantly lower mean LA-VA ratios of the medium sized intracranial arteries and their primary branches, small intracerebral arteries and arterioles than the controls (P < 0.001). The stroke patients had higher mean VW-VR ratios of these arteries than the controls (P < 0.001). Atherosclerotic narrowing of the medium sized intracranial arteries and their primary branch were more severe than those of the extracranial caotid arteries. Moreover, the proximal portion of the primary branch arteries was much more severe than that of extracranial caotid arteries (P < 0.01, P < 0.05) in the stroke patients. CONCLUSION: Stroke patients had atherosclerotic lesions of the intracranial medium sized arteries and their primary branches and sclerotic lesions of the small intracerebral arteries and arterioles. These pathological changes resulted in thickening arterial walls and narrowing arterial lumens. 相似文献
3.
Nishihori K. Kitaura Y. Hirose M. Mihara M. Nagaoka M. Uchitomi N. 《Electron Devices, IEEE Transactions on》1998,45(7):1385-1392
This paper describes a newly developed GaAs metal semiconductor field-effect transistor (MESFET)-termed p-pocket MESFET-for use as a linear power amplifier in personal handy-phone systems. Conventional buried p-layer technology, the primary technology for microwave GaAs power MESFET's, has a drawback of low power efficiency for linear power applications. The low power efficiency of the buried p-layer MESFET is ascribed to the I-V kink which is caused by holes collected in the buried p-layer under the channel. In order to overcome this problem, we have developed the self-aligned gate p-pocket MESFET which incorporates p-layers not under the channel but under the source and drain regions. This new MESFET exhibited high transconductance and uniform threshold voltage. The problematic I-V kink was successfully removed and an improved power efficiency of 48% was achieved under bias conditions, which resulted in adjacent channel leakage power at 600-kHz offset as low as -59 dBc for 1.9-GHz π/4-shift QPSK modulated input 相似文献
4.
Eri Chatani Keisuke Yuzu Yumiko Ohhashi Yuji Goto 《International journal of molecular sciences》2021,22(9)
Amyloid fibrils are supramolecular protein assemblies represented by a cross-β structure and fibrous morphology, whose structural architecture has been previously investigated. While amyloid fibrils are basically a main-chain-dominated structure consisting of a backbone of hydrogen bonds, side-chain interactions also play an important role in determining their detailed structures and physicochemical properties. In amyloid fibrils comprising short peptide segments, a steric zipper where a pair of β-sheets with side chains interdigitate tightly is found as a fundamental motif. In amyloid fibrils comprising longer polypeptides, each polypeptide chain folds into a planar structure composed of several β-strands linked by turns or loops, and the steric zippers are formed locally to stabilize the structure. Multiple segments capable of forming steric zippers are contained within a single protein molecule in many cases, and polymorphism appears as a result of the diverse regions and counterparts of the steric zippers. Furthermore, the β-solenoid structure, where the polypeptide chain folds in a solenoid shape with side chains packed inside, is recognized as another important amyloid motif. While side-chain interactions are primarily achieved by non-polar residues in disease-related amyloid fibrils, the participation of hydrophilic and charged residues is prominent in functional amyloids, which often leads to spatiotemporally controlled fibrillation, high reversibility, and the formation of labile amyloids with kinked backbone topology. Achieving precise control of the side-chain interactions within amyloid structures will open up a new horizon for designing useful amyloid-based nanomaterials. 相似文献
5.
Dr. Daisuke Fujiwara Kousuke Mihara Ryo Takayama Yusuke Nakamura Prof. Mitsuhiro Ueda Prof. Takeshi Tsumuraya Prof. Ikuo Fujii 《Chembiochem : a European journal of chemical biology》2021,22(24):3406-3409
Conformationally constrained peptides hold promise as molecular tools in chemical biology and as a new modality in drug discovery. The construction and screening of a target-focused library could be a promising approach for the generation of de novo ligands or inhibitors against target proteins. Here, we have prepared a protein kinase-focused library by chemically modifying helix-loop-helix (HLH) peptides displayed on phage and subsequently tethered to adenosine. The library was screened against aurora kinase A (AurA). The selected HLH peptide Bip - 3 retained the α-helical structure and bound to AurA with a KD value of 13.7 μM. Bip - 3 and the adenosine-tethered peptide Bip - 3 - Adc provided IC50 values of 103 μM and 7.7 μM, respectively, suggesting that Bip - 3 - Adc bivalently inhibited AurA. In addition, the selectivity of Bip - 3 - Adc to several protein kinases was tested, and was highest against AurA. These results demonstrate that chemical modification can enable the construction of a kinase-focused library of phage-displayed HLH peptides. 相似文献
6.
The liver lipogenic enzymes are compared among rats, chickens, frogs and fish. Although the apparent Km values of glucose-6-phosphate
dehydrogenase for glucose-6-phosphate are not much different among all the species, those of malic enzyme for malate are much
higher in chickens and fish than in rats and frogs. Glucose-6-phosphate dehydrogenase showed very high activities compared
with malic enzyme in fish liver, and malic enzyme showed high activities in chicken liver. Although the apparent Km values
of acetyl-CoA carboxylase and fatty acid synthetase for substrates are in the same range among all the animals, the activity
of acetyl-CoA carboxylase seems to be extremely low in fish and frog livers, and that of fatty acid synthetase is low in frog
livers only. In addition, the apparent Km values of α-glycerophosphate acyltransferase of fish liver are very high, and the
enzyme activity appears to be extremely low compared to the others. Therefore, the enzymes at the first steps of both fatty
acid and glycerolipid syntheses of poikilothermos animals appear to be very low. On the other hand, the Ouchterlony double-diffusion
patterns showed that the lipogenic enzymes of chickens, frogs and fish are immunologically different from those of rats, with
the exception of acetyl-CoA carboxylase in chickens. Therefore, it is suggested that the fatty acid and glycerolipid forming
systems of poikilothermos animals are quite different from those of homoiothermos and the lipogenesis is very low in poikilothermos. 相似文献
7.
This paper is concerned with the stability analysis of a networked control system, wherein communication from the controller to the plant input is through a digital channel subject to packet-dropouts and finite-level quantization. No acknowledgments of receipt are available to the controller. To alleviate the effect of packet-dropouts, the controller transmits tentative plant input sequences. Within this setup, we derive a sufficient condition for small ?∞ signal ?∞ stability of the networked control system. This condition requires the maximum number of consecutive packet-dropouts to be bounded. We also elucidate the trade-off which exists between the disturbance attenuation and the step size of the quantizer and the maximum number of consecutive packet-dropouts. 相似文献
8.
9.
Motonaka Kuroda Yumiko Kato Junko Yamazaki Naoko Kageyama Toshimi Mizukoshi Hiroshi Miyano Yuzuru Eto 《Food chemistry》2012
The determination of the kokumi peptide, γ-glutamyl-valyl-glycine (γ-Glu-Val-Gly) in raw scallop and processed scallop products was carried out using high pressure liquid chromatography–tandem mass spectrometry (LC/MS/MS). The detection of γ-Glu-Val-Gly was achieved using a multiple reaction monitoring (MRM) method. The optimised condition enabled the precise determination of γ-Glu-Val-Gly. Raw scallop contained 0.08 μg/g γ-Glu-Val-Gly, and the γ-Glu-Val-Gly levels in processed scallop products, such as dried-scallop and scallop extract, were measured to be 0.64 and 0.77 μg/g, respectively. This is the first report to confirm the existence of γ-Glu-Val-Gly in foodstuff. 相似文献
10.
Hyunjeong Kim Kouji Sakaki Itoko Saita Hirotoshi Enoki Kazuo Noguchi Akihiko Machida Tetsu Watanuki Yumiko Nakamura 《International Journal of Hydrogen Energy》2014
The effect of the vanadium content on the cyclic stability of V–Ti binary alloys was investigated. V1−xTix, x = 0.2 and 0.5 samples were hydrogenated and dehydrogenated at 410 K and 553 K respectively, for more than 100 times. During hydrogen cycling, reduction in the reversible hydrogen storage capacity was clearly observed from both samples. No prominent V-effect was found. In fact, the reduction rates of two samples were similar; both samples showed a ∼25% reduction in the reversible hydrogen storage capacity after 100 cycles. In addition, the shape of the pressure–composition-isotherm (PCT) curves was significantly altered over the testing cycle period; the absorption and desorption plateaus got markedly inclined and the hysteresis became evidently smaller. We found that even after the hydrogen storage capacity of V1−xTix was significantly reduced, at low enough temperature V1−xTix was able to absorb hydrogen as much as it did at the first cycle. Furthermore, the reversible hydrogen storage capacity of V0.8Ti0.2 at 410 K was recovered to a certain degree after hydrogenating the sample at low temperatures. 相似文献