HPLC-MS/MS测定大鼠血浆中长春瑞滨的浓度及其药代动力学研究

An high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) method for the determination of vinorelbine was presented, and the pharmacokinetics of the aqueous solution and lipid microspheres by intravenous were evaluated. Detection was performed using positive ion electrometry ionization followed by tandem mass spectrometry(ESI-MS/MS). The linear range of the standard curve of vinorelbine is from 1 to 1 000 μg•L^－1. The method shows that it is specificity, convenient and suitable for assaying the concentration of vinorelbine in rat plasma, and is used to support pharmacologic studies with vinorelbine and preparation technology for lipid microspheres.     

等通道球形转角挤压过程中工业纯铝的微观组织演变与力学性能

突破传统ECAP变形全过程通道等截面思路,提出一种耦合剪切应变和正应变于一体的新型等通道球形转角挤压(equal channel angular extrusion with spherical cavity,ECAE-SC)工艺。在自行研制的模具上对工业纯铝进行室温单道次ECAE-SC挤压实验,采用OM、EBSD和TEM等技术手段,研究了ECAE-SC变形过程中工业纯铝微观组织的演变规律,并测试了变形后试样的显微硬度。结果表明,在ECAE-SC工艺剧烈简单剪切变形诱导下,工业纯铝仅需1道次挤压变形即可获得等轴、细小、均匀的超细晶组织,平均晶粒尺寸约为400 nm;工业纯铝室温ECAE-SC变形以位错滑移为主并伴有不完全连续动态再结晶,其微观组织经历了剪切带→位错胞→小角度亚晶→大角度等轴晶粒等动态演化过程。1道次ECAE-SC变形后,工业纯铝组织以{110}001高斯织构为主,同时存在部分{111}112铜型织构;材料显微硬度值大幅提升,由初始289.4 MPa提高到565.3 MPa,增幅高达95.33%,且分布均匀性良好。     

合金元素Zr对Cu-Y2O3复合材料组织和性能的影响(英文)

通过机械合金化和放电等离子烧结制备Cu-Y₂O₃和Cu-Y₂O₃-Zr复合材料，并采用光学显微镜、扫描电镜、透射电镜、电导率和拉伸实验对其组织和性能进行系统研究。研究发现，复合材料的显微组织对其力学性能和电导率具有很大影响。电学性能的改善可归因于共格Y₄Zr₃O₁₂粒子的形成和Cu₄Zr相的优先成核，它们分别改善了Y₂O₃和Cu基体之间的界面以及降低了位错密度。此外，Cu-Y₂O₃-Zr复合材料的屈服强度为265.6 MPa，极限抗拉强度为301.0 MPa，伸长率为23.6%，电导率达到92.0%(IACS)。