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1.
Sama Rezasoltani Reza Ghanbari Mehdi Azizmohammad Looha Ehsan Nazemalhosseini Mojarad Abbas Yadegar Delisha Stewart Hamid Asadzadeh Aghdaei Mohammad Reza Zali 《International journal of molecular sciences》2020,21(23)
Abnormal activation of Toll-like receptor (TLRs) signaling can result in colon cancer development. The aim of this study was to investigate the expression of important TLRs in different histological types of colorectal polyps and evaluate their relationship with intestinal microbiota. The expression levels of TLR2, 3, 4, and 5 were analyzed in intestinal biopsy specimens of 21 hyperplastic polyp (HP), 16 sessile serrated adenoma (SSA), 29 tubular adenoma (TA), 21 villous/tubulovillous (VP/TVP) cases, and 31 normal controls. In addition, selected gut bacteria including Streptococcus bovis, Enterococcus faecalis, Enterotoxigenic Bacteroides fragilis (ETBF), Fusobacterium nucleatum, Porphyromonas spp., Lactobacillus spp., Roseburia spp., and Bifidobacterium spp. were quantified in fecal samples using absolute qRT PCR, and, finally, the association between TLRs and these gut microbiota- was evaluated by Spearman’s correlation coefficient. Higher expression of TLR2 and TLR4 in VP/TVP and TA, and lower expression levels of TLR3 and TLR5 in all type of polyps were observed. The differences in TLR expression patterns was not only dependent on the histology, location, size, and dysplasia grade of polyps but also related to the intestinal microbiota patterns. TLR2 and TLR4 expression was directly associated with the F. nucleatum, E. faecalis, S. bovis, Porphyromonas, and inversely to Bifidobacterium, Lactobacillus, and Roseburia quantity. Furthermore, TLR3 and TLR5 expression was directly associated with Bifidobacterium, Roseburia, and Lactobacillus quantity. Our results suggest a possible critical role of TLRs during colorectal polyp progression. An abnormal regulation of TLRs in relation to gut microbial quantity may contribute to carcinogenesis. 相似文献
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3.
Abdelbaki Benamor Brahim Si Ali Mohamed Kheireddine Aroua 《Korean Journal of Chemical Engineering》2008,25(3):451-460
The absorption rates of CO2 into aqueous solutions of Diethanolamine (DEA) with varying concentrations from 0.2 to 4M and temperature range from 293
to 323 K were measured by using a laboratory stirred reactor. The CO2 partial pressure was varied in a range that the reaction would occur in pseudo first order regime. Experimental data were
analyzed and the kinetic parameters associated with the reaction were determined. The activation energy for the deprotonation
of the intermediate zwitterion was estimated at about 11.4 kcal/mol. The contribution of carbamate formation to the overall
absorbed CO2 was experimentally evaluated and found to be of the order of 100%. 相似文献
4.
Weekly storage of coolness in heavy walls (walls with large thermal inertia or large characteristic time constants or low Fourier numbers) was investigated numerically by considering one-dimensional heat conduction through the walls. The study consisted of first analyzing the heat flow through a single wall and considering various boundary conditions on the inside. The boundary conditions were: constant inside air tempeture throughout the day, variable inside air temperature on a 24-hour cycle, and variable inside air temperature on a 48-hour cycle. Next, the heat flow through walls was studied through a thermal network analysis of a simple building. In this case it was assumed that the ambient air temperature (following a periodic distribution) was increased suddenly and followed this new distribution for many days thereafter.It was concluded that walls with high thermal inertia or time constant can store coolness for several days. The larger the time constant of the wall (for example adobe as compared with brick) the longer it takes for the wall temperature to reach a steady periodic distribution after the change has occurred. However, because of low thermal conductivity of adobe, the retrieval of the stored coolness in these walls is slow, and the mean daily temperature of the room air in the adobe building does not change appreciably beyond seven days after the change. Increase of the wall thickness beyond 50 cm does not improve the thermal performance of the building significantly. 相似文献
5.
Ahmad Nozad Golikand Elaheh Lohrasbi Mohammad Ghannadi Maragheh Mehdi Asgari 《Journal of Applied Electrochemistry》2008,38(6):869-874
The effect of carbon surface oxidation on platinum supported carbon particles (Pt/C) with nitric acid was investigated by
cyclic voltammetry, electrochemical impedance spectroscopy, polarization experiments and chronoamperometry. Cyclic voltammograms,
polarization curves and electrochemical impedance spectra showed that the treated catalyst had much larger active surface
area and higher ionic conductivity than the untreated catalyst, and provided enhanced performance for oxygen reduction. The
formation of acidic groups was examined by IR spectra. The Pt/C surface oxidation had a large effect on the performance of
a gas diffusion electrode for oxygen reduction reaction. 相似文献
6.
Khalid Mahmood Zia Mehdi Barikani Ijaz Ahmad Bhatti Mohammad Zuber Haq Nawaz Bhatti 《应用聚合物科学杂志》2008,109(3):1840-1849
A series of polyurethane (PU) elastomers was prepared by the reaction of poly(?‐caprolactone) and 4,4′‐diphenylmethane diisocyanate, which was extended with a series of chain extenders (CEs) having 2–10 methylene units in their structure. The completion of the reaction was confirmed by Fourier transform infrared spectroscopy. The chemical structures of the synthesized PU samples were characterized with Fourier transform infrared, 1H‐NMR, and 13C‐NMR spectroscopy, and the thermal properties were determined by thermogravimetric analysis, DSC, and dynamic mechanical thermal analysis techniques. The mechanical properties were also studied and are discussed. The thermogravimetric analysis and DSC analysis showed that CE length had a considerable effect on the thermal properties of the prepared samples. The dynamic mechanical thermal analysis and damping peaks were also affected by the number of methylene units in the CE length. The elastomer extended with 1,2‐ethane diol exhibited optimum thermal properties, whereas the elastomer based on 1,10‐decane diol displayed the worst thermal properties. Tensile strength and elongation at break decreased with increasing CE length, whereas hardness showed the opposite trend. The glass‐transition temperature moved toward lower temperatures with increasing CE length. The decrease in the glass‐transition temperature and tensile properties were interpreted in terms of decreasing hard segments and increasing chain flexibility. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 相似文献
7.
Fabrice Martin Marc-Etienne Jan Samuel Rey-Mermet Brahim Belgacem Dong Su Marco Cantoni Paul Muralt 《IEEE transactions on ultrasonics, ferroelectrics, and frequency control》2006,53(7):1339-1343
Polycrystalline A1N thin films were deposited by RF reactive magnetron sputtering on Pt(111)/Ti electrode films. The substrates were tilted by an angle ranging from 40 degrees to 70 degrees with respect to the target normal. A low deposition temperature and a high sputter gas pressure were found ideal for tilted growth. The resulting grain tilt angle amounts to about half the substrate tilt angle. For coupling evaluation, 5 GHz solidly mounted resonator structures have been realized. The tilted grain A1N films exhibited a permittivity in the 9.5-10.5 range and loss tangent of 0.3%. Two shear modes as well as the longitudinal mode could be clearly identified. The coupling coefficient k2(eff) of the fundamental thickness shear mode (TS0) was found to be about 0.5%, which is compatible with a c-axis tilt of about 6 degrees. 相似文献
8.
Influence of thermal boundary conditions on natural convection in a square enclosure partially heated from below 总被引:1,自引:0,他引:1
Nader Ben Cheikh Brahim Ben BeyaTaieb Lili 《International Communications in Heat and Mass Transfer》2007
Natural convection in air-filled 2D square enclosure heated with a constant source from below and cooled from above is studied numerically for a variety of thermal boundary conditions at the top and sidewalls. Simulations are performed for two kinds of lengths of the heated source, i.e., a small and a large source corresponding to 20% and 80% of the total length of the bottom wall, respectively. The Rayleigh number varied from 103 to 107. Results are presented in the form of streamline and isotherm plots as well as the variation of the Nusselt number and maximum temperature at the heat source surface. Comparisons among the different thermal configurations considered are reported. 相似文献
9.
Kheirandish Davar Haghparast Majid Reshadi Midia Hosseinzadeh Mehdi 《The Journal of supercomputing》2021,77(12):13828-13862
The Journal of Supercomputing - Recently, the synthesis of reversible sequential circuits has attracted researchers’ attention for implementing low-power logic designs. So far, the direct and... 相似文献
10.
Neural Computing and Applications - Feature selection is frequently used as a preprocessing step to data mining and is attracting growing attention due to the increasing amounts of data emerging... 相似文献