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Qin J Chen D Lu W Xu H Yan C Hu H Chen B Qiao M Zhao X 《Drug development and industrial pharmacy》2008,34(6):602-608
In the present study, various gradients were evaluated for efficient loading of weak acid into liposomes. Several salt gradients showed efficient loading of ferulic acid (FA) into liposomes and the optimized conditions were established in calcium acetate gradient method to obtain 80.2 +/- 5.2% entrapment efficiency (EE). Unilamellar vesicles were observed in micrographs and liposomal FA showed good stability. 80% of FA was released from liposomes within 5 h in vitro. There is a novel finding in this study: that drugs could be entrapped with a high solubility in the intraliposomal buffer in contrast to the low solubility in the extraliposomal buffer. The results of body distribution in rats indicated that liposomes could improve the body distribution of FA. For FA liposome, the concentration of FA in brain was two-fold higher than that of free FA. Liposomal FA was a promising approach to improve the body distribution of FA. 相似文献
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Jing Qin DaWei Chen WeiGen Lu Huan Xu ChenYun Yan HaiYang Hu 《Drug development and industrial pharmacy》2013,39(6):602-608
In the present study, various gradients were evaluated for efficient loading of weak acid into liposomes. Several salt gradients showed efficient loading of ferulic acid (FA) into liposomes and the optimized conditions were established in calcium acetate gradient method to obtain 80.2 ± 5.2% entrapment efficiency (EE). Unilamellar vesicles were observed in micrographs and liposomal FA showed good stability. 80% of FA was released from liposomes within 5 h in vitro. There is a novel finding in this study: that drugs could be entrapped with a high solubility in the intraliposomal buffer in contrast to the low solubility in the extraliposomal buffer. The results of body distribution in rats indicated that liposomes could improve the body distribution of FA. For FA liposome, the concentration of FA in brain was two-fold higher than that of free FA. Liposomal FA was a promising approach to improve the body distribution of FA. 相似文献
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A novel strategy has been developed to prepare hollow structured Nafion-modified-graphene/polyaniline (NGP) composites via interfacial assembly polymerization between an aqueous phase containing oxidant and an organic phase containing aniline monomers and Nafion-modified graphene. Fourier transform infrared (FTIR), Ultraviolet-visible (UV-vis) and X-ray diffraction (XRD) analyses confirmed the generation of polyaniline (PANI) on graphene during the interfacial polymerization. The morphological evolution of the product had been investigated by scanning electron microscopy (SEM) with respect to the reaction time, based on which a conceivable interpretation of the growth mechanism of the sphere architectures with composite component were given. The as-prepared hollow structured composites showed a good rate capability as electrode material for supercapacitor, and the as-designed interfacial assembly preparation strategy for such composites may provide a generic guideline in developing other graphene-base composite hollow spheres with different compositions. 相似文献
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