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Cosimo Pallavicini 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1982,175(4):249-252
Summary Changes in peptides and their amino-acid composition that take place during the plastein reaction carried out with immobilized-chymotrypsin as a catalyst and with the low-molecular weight peptide fraction of alfalfa (Medicago sativa) leaf protein hydrolyzate as substrate were studied. By thin-layer fingerprint chromatography the substrate and the plastein reaction product exhibited five and six peptide species, respectively. The analysis of their amino-acid composition indicated that the substrate peptides in two cases gave rise to plastein peptides by slight apparent compositional changes, in the other cases instead they underwent more pronounced modifications.
This work was supported by the Consiglio Nazionale delle Ricerche, Roma, Italy 相似文献
Veränderungen einiger Peptide aus Luzerneblattproteinen als Ergebnis einer Plastein-Reaktion mit immobilisiertem -Chymotrypsin
Zusammenfassung Es wurden Veränderungen der Peptide und deren Aminosäuren-Zusammensetzung im Laufe der Plastein-Reaktion erforscht, die mit Hilfe von als Katalysator wirkenden immobilisiertem -Chymotrypsin und einer Peptid-Fraktion mit niedrigem Molekulargewicht aus einem Hydrolysat von Luzerneproteinen (Medicago sativa) als Substrat durchgeführt wurde. Durch Dünnschichtfingerabdruck-Chromatographie zeigten Substrat und Produkt der Plastein-Reaktion fünf bzw. sechs Peptide. Die Analysen ihrer Aminosäuren-Zusammensetzung zeigte in zwei Fällen, daß die Substratpeptide in Plasteinpeptide übergingen, bei scheinbar geringen Veränderungen in der Zusammensetzung. In den übrigen Fällen ergaben sich tiefgreifendere Veränderungen.
This work was supported by the Consiglio Nazionale delle Ricerche, Roma, Italy 相似文献
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Francesco Merola Simonetta Grilli Sara Coppola Veronica Vespini Sergio De Nicola Pasquale Maddalena Cosimo Carfagna Pietro Ferraro 《Advanced functional materials》2012,22(15):3267-3272
Investigation on the behavior of nematic liquid crystals on functionalized polar dielectric crystal substrates is accomplished. Very interesting effects can be observed in maneuvering liquid crystal droplets on the substrate surface, driven by electric fields generated by pyroelectric effect. Reversible drops fragmentation and self‐assembling in different configurations can be achieved. The dynamics of the observed phenomena is studied and the repeatability of the process is full assessed. 相似文献
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Modern cloud data centers rely on server consolidation (the allocation of several virtual machines on the same physical host) to minimize their costs. Choosing the right consolidation level (how many and which virtual machines are assigned to a physical server) is a challenging problem, because contemporary multitier cloud applications must meet service level agreements in face of highly dynamic, nonstationary, and bursty workloads. In this paper, we deal with the problem of achieving the best consolidation level that can be attained without violating application service level agreements. We tackle this problem by devising fuzzy controller for consolidation and QoS (FC2Q), a resource management framework exploiting feedback fuzzy logic control, that is able to dynamically adapt the physical CPU capacity allocated to the tiers of an application in order to precisely match the needs induced by the intensity of its current workload. We implement FC2Q on a real testbed and use this implementation to demonstrate its ability of meeting the aforementioned goals by means of a thorough experimental evaluation, carried out with real‐world cloud applications and workloads. Furthermore, we compare the performance achieved by FC2Q against those attained by existing state‐of‐the‐art alternative solutions, and we show that FC2Q works better than them in all the considered experimental scenarios. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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C Bulletti C Flamigni V Polli E Giacomucci A Albonetti V Negrini A Galassi AM Morselli-Labate 《Canadian Metallurgical Quarterly》1996,3(4):495-501
STUDY OBJECTIVE: To establish the crude effects of danazol and gonadotropin-releasing hormone (GnRH) analogs in the management of endometriosis. DESIGN: Prospective case-control study. SETTING: Unit of the Pathophysiology of Reproduction outpatient department. PATIENTS: Two groups of 110 women each with endometriosis (American Fertility Society score 1-3) who received danazol and GnRH analogs, and a control group who did not receive any drugs. INTERVENTIONS: Women in the treatment groups received danazol 200 mg every 8 hours for 6 months, or a different GnRH agonist at standard dosages for 6 months. Laparoscopy was performed twice, at the time of diagnosis and just before the end of treatment (or no therapy for controls). Surgical treatment of the implants was performed at the second laparoscopy. MEASUREMENTS AND MAIN RESULTS: Samples of both eutopic and ectopic endometrium were collected during both laparoscopies. Both danazol and GnRH agonists were useful in reducing the AFS scores to inactive endometriotic implants, and there were no significant differences between the effects (p <0.001). Fibrosis was found after 6 months of observation in the implants in one control woman (0.9%), in 20 patients (18.2%) treated with danazol (p <0.001 vs controls), and in 4 patients (3.6%) treated with GnRH agonists (NS vs controls). A correlation between a clinical diagnosis of AFS score zero and histologic features of fibrosis in the ectopic specimens after therapies was observed in 28% of women, with poor agreement (k = 0.07). CONCLUSIONS: Fibrosis, which represent the absence of endometrial cells within the specimens of endometriotic lesions or eutopic endometrium, did not appear in eutopic endometria but it was found in some endometriotic implants. Danazol and GnRH agonists reduced the clinical AFS scores of endometriosis, but their histologic effects in completely and permanently eliminating endometriotic implants were unacceptable. 相似文献
6.
A computer running under a Unix operating system is an excellent host on which to develop software for target systems which have the same type of microprocessor as the host computer. Unfortunately, facilities for preparing executable modules able to be sent to an EPROM programmer or to be loaded onto a RAM portion of target memory space are lacking in standard Unix. These facilities can be improved in any version of Unix without the need for expensive software using the set of commands presented in this paper. 相似文献
7.
This paper describes the energy consumption performance of sea-going ships engaged in the EU27 seaborne trades based on data and parameters resulting from the EX-TREMIS (EXploring non road TRansport EMISsions in Europe) database. EX-TREMIS is a comprehensive database of fleet and transport activity data, specific energy consumption, emission factors and total emissions from rail, maritime and air transport in the European Union. The EX-TREMIS maritime model derives from a mixture of top–down and bottom–up approaches for estimating pollutant emissions from shipping activities. The model did not use direct observations of actual trips, but empirically derived the number of equivalent-ships. Cargo type shipments were linked to seven ship type categories for which a further segmentation by ship size (three length classes), type and age of the main engine and type of fuel was applied. 相似文献
8.
Costanza Renata Neri Serena Scapaticci Francesco Chiarelli Cosimo Giannini 《International journal of molecular sciences》2022,23(9)
Obesity is one of the greatest health challenges affecting children of all ages and ethnicities. Almost 19% of children and adolescents worldwide are overweight or obese, with an upward trend in the last decades. These reports imply an increased risk of fat accumulation in hepatic cells leading to a series of histological hepatic damages gathered under the acronym NAFLD (Non-Alcoholic Fatty Liver Disease). Due to the complex dynamics underlying this condition, it has been recently renamed as ‘Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD)’, supporting the hypothesis that hepatic steatosis is a key component of the large group of clinical and laboratory abnormalities of Metabolic Syndrome (MetS). This review aims to share the latest scientific knowledge on MAFLD in children in an attempt to offer novel insights into the complex dynamics underlying this condition, focusing on the novel molecular aspects. Although there is still no treatment with a proven efficacy for this condition, starting from the molecular basis of the disease, MAFLD’s therapeutic landscape is rapidly expanding, and different medications seem to act as modifiers of liver steatosis, inflammation, and fibrosis. 相似文献
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