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Werner Hoffmann 《International journal of molecular sciences》2015,16(8):19153-19169
Gastric cancer is still a leading cause of cancer-related mortality worldwide in spite of declining incidence. Gastric cancers are, essentially, adenocarcinomas and one of the strongest risk factors is still infection with Helicobacter pylori. Within the last years, it became clear that gastric self-renewal and carcinogenesis are intimately linked, particularly during chronic inflammatory conditions. Generally, gastric cancer is now regarded as a disease resulting from dysregulated differentiation of stem and progenitor cells, mainly due to an inflammatory environment. However, the situation in the stomach is rather complex, consisting of two types of gastric units which show bidirectional self-renewal from an unexpectedly large variety of progenitor/stem cell populations. As in many other tumors, cancer stem cells have also been characterized for gastric cancer. This review focuses on the various gastric epithelial stem cells, how they contribute to self-renewal and which routes are known to gastric adenocarcinomas, including their stem cells. 相似文献
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Annika Jahn Anton Hoffmann Luisa Blaesing Fabian Kunde Martin Bertau Martina Bremer Steffen Fischer 《化学,工程师,技术》2020,92(11):1733-1740
The enzymatic conversion of lignins, possibly in combination with electrochemical oxidation, makes aromatics such as syringol, guaiacol, vanillin and catechol available in the qualities required by the fragrance industry. The lignins were obtained by soda digestion from wheat straw and Miscanthus, characterized and then converted with laccases. The overall yield amounted up to 9 wt % with a product spectrum confined to four substances. Catechol was the major product, with a fraction of ≈75 %. It can easily be isolated by extraction with acetone. 相似文献
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Roland Gabriel Jürgen Kunz Lars Schwarze Peter Fettke Christian Scheer Franz Lehner Konrad Walser Thomas Deelmann 《WIRTSCHAFTSINFORMATIK》2006,48(3):218-222
Ohne Zusammenfassung 相似文献
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An analytical solution is presented to the problem of steady groundwater flow seeping into a pumped cylindrical hole partially penetrating a homogeneous and anisotropic confined aquifer overlying a gravel substratum. Solutions are obtained for two general cases of the problem: (1) when the level of the pumped hole is below the confining layer; (2) when it is above it. The validity of the proposed theory is tested by comparing analytical predictions obtained for a few flow situations with corresponding results obtained by numerical means. The theory presented here can be utilized to convert the rate of rise of water in a pumped auger hole into directional conductivities of soil, in areas where water is found to be in a confined state overlying a gravel substratum. The study shows that the conductivity values calculated by neglecting the confining pressure of an artesian aquifer with a gravel base [i.e., by applying the existing (Boast and Kirkham in 1971), auger hole seepage theory for a phreatic aquifer with a gravel base to confined situations] may result in serious error; hence, the artesian head of an aquifer must be accounted for while computing the conductivity values. Further, it is observed that the area contributing flow to a pumped auger hole/well with a gravel base is mostly restricted to a short radial distance from the center of the hole, particularly for situations where the gravel substratum is located close to the bottom of the hole. This is in contrast to auger hole flow situations overlying an impervious substratum, where the domain contributing flow is mostly spread out to a considerable distance from the center of the hole. 相似文献
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