Specimens of partially stabilized zirconia were slip cast from aqueous suspensions and sintered at 1500°C for 3 h. The relative density of the cast specimens and the firing shrinkage of the sintered specimens depend on the milling time for the suspension. Vickers hardness and KIC values of 11.46±s0.07 GN/m2 and 6.10 ±0.04 MN.m3/2, respectively, were obtained for all sintered specimens. The dispersion of the suspension is important in increasing the relative density of the cast specimens. 相似文献
The effects of a novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, HL-004, on cholesterol metabolism were examined in mice peritoneal macrophages. Cholesteryl ester-rich foam cells were induced by incubating macrophages with acetylated LDL. HL-004 prevented the accumulation of cholesteryl ester in the presence of the cholesterol acceptor, HDL. In the absence of HDL, HL-004 generated large amounts of free cholesterol in the cell. Moreover, HL-004 stimulated the efflux of cholesterol from preestablished foam cells in the presence of HDL. These results suggest that the inhibition of foam cell formation and the stimulation of foam cell regression by HL-004 are attributed to intracellular ACAT inhibition, and that HL-004 would be expected to exhibit an antiatherosclerotic effect through direct action on arterial wall. 相似文献
Istanbul is one of the most famous historical cities in the world. However, the project alignment selected as the best of a range of alignments cannot avoid passing beneath the historical and cultural heritages of Istanbul as well as under ancient and densely inhabited areas of the city. This paper will explain some of the challenges related to the bored tunnels.
Historical buildings are vulnerable. Yet many existing residential and office buildings are old and constructed on minimal foundations. As a consequence, it is vital that any drawdown of groundwater and any ground settlements have to be minimized.
In addition, the connection between the immersed and bored tunnels will be made directly and totally underground, without the usual intermediate shafts and beneath the deep waters of the Bosphorus Strait. This operation needs the utmost control of the tunnel excavation face to ensure its stability and to minimize water ingress. Based on such considerations, tunnel excavation by tunnel boring machine (TBM) using a slurry shield and having the ability to operate under high pore pressures was recommended as the method of excavation for the main running tunnels.
The paper will explain how the design team from Avrasyaconsult – the Employer’s Representative – arrived at the final minimum, specific and functional requirements of the bored tunneling works which are to be carried out using the ‘FIDIC EPC/Turnkey Project’ conditions. 相似文献
An implicit tenet of modern search heuristics is that there is a mutually exclusive balance between two desirable goals: search
diversity (or distribution), i.e., search through a maximum number of distinct areas, and, search intensity, i.e., a maximum
search exploitation within each specific area. We claim that the hypothesis that these goals are mutually exclusive is false
in parallel systems. We argue that it is possible to devise methods that exhibit high search intensity and high search diversity
during the whole algorithmic execution. It is considered how distance metrics, i.e., functions for measuring diversity (given
by the minimum number of local search steps between two solutions) and coordination policies, i.e., mechanisms for directing
and redirecting search processes based on the information acquired by the distance metrics, can be used together to integrate
a framework for the development of advanced collective search methods that present such desiderata of search intensity and
search diversity under simultaneous coexistence. The presented model also avoids the undesirable occurrence of a problem we
refer to as the ‘ergometric bike phenomenon’. Finally, this work is one of the very few analysis accomplished on a level of
meta-meta-heuristics, because all arguments are independent of specific problems handled (such as scheduling, planning, etc.),
of specific solution methods (such as genetic algorithms, simulated annealing, tabu search, etc.) and of specific neighborhood
or genetic operators (2-opt, crossover, etc.). 相似文献