Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances

Carriers for targeted delivery and controlled release of poorly water-soluble active substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b) limitations of PWSAS water solubility, and (c) burst drug release which can be pharmacologically dangerous and economically inefficient. The present study brings a novel strategy for encapsulation and controlled release of PWSAS—caffeine in concentrations which are higher than its maximal water solubility without the possibility of burst effect. The modification of hydrophilic carrier based on poly(methacylic acid) was done using casein and liposomes. To further increase the maximal caffeine loading inside the carrier nicotinamide was used. The release study of the encapsulated PWSAS was elaborated with respect to morphology of the carriers and interactions that could be established between its structural components. The carriers swelling and the release of caffeine and nicotinamide were also investigated depending on caffeine concentration, the presence of different liposomal formulations and the volume ratio of liposomal formulation, in three media with different pH simulating the path of the carrier through the human gastrointestinal tract. The synthesized carriers are promising candidates for encapsulation of PWSAS in concentrations which are higher than its maximal water solubility and for the targeted delivery of those dosages.     

Fluctuations and waves in fluidized bed systems: The influence of the air-supply system

A general model of the response of a fluidized bed to disturbances is formulated, and the information provided by the model with respect to the dynamics of the bed, the bed plus the air-plenum and the bed plus the entire air-supply system, is investigated. Expressions given in literature on the fundamental frequency of the bed-plenum system are analyzed, and it is shown that they are a special case of the general model. In order to simulate various types of interaction between the bed and the rest of the system, experiments were performed in a cold fluidized bed unit operated under both non-circulating and circulating conditions. At low velocity, three regimes were identified: the multiple bubble regime with almost no interaction between bed and air-plenum, the single bubble regime with the interaction between bed and air-plenum only, and a regime with numerous irregular bubbles, where the bed interacted with the entire air-supply system. At high fluidization velocity, the exploding bubble regime was identified, with the same dominant frequency as that of the single bubble regime (the interaction with the air-supply system remains at that frequency). The models investigated correctly reproduce the dynamics when the bed is independent of the other parts of the system, or when the bed interacts only with the air-plenum. However, the models are only partially applicable when the bed interacts with the entire air-supply system. The reasons for this are investigated. In the case of system interaction, pressure waves, generated in the bed, interact with pressure pulsations from the air-supply system. This results in a coupled system, which is not covered by the models. Pressure waves resulting from events in the bed, are recognized as the coherent part of the cross power spectra of pressure fluctuations measured in the bed and the air-plenum.     

Stabilization of fixed modes in expansions of LTI systems

The objective of this note is to propose a method for stabilization of structurally fixed modes in expansions of LTI dynamic systems in the scope of overlapping decentralized control design based on the expansion/contraction framework, enabling successful design for a broader class of problems than considered so far. The method is based on a judicious choice of complementary matrices in the expanded space. Numerical examples are provided to illustrate simplicity and efficiency of the proposed approach.     

Measuring probe for fast transients monitoring in gas insulatedsubstation

This paper describes the construction of four probes adjusted for fast transient monitoring in 123 kV SF₆ insulated substations. The primary requirement was the ability to monitor without distortion very fast transients containing frequencies up to 200 MHz. The measuring system was tested and calibrated with the help of computer modeling techniques. The verified experimental apparatus was then used for testing and calibrating the measuring probes. During the test, various effects on the measuring system characteristics were analyzed with respect to materials used for the components of the system     

Electrooxidation of CO and CO/H2 mixtures on a Pt-Sn catalyst prepared by an implantation method

A new type of ion implantation technique is used to create a non-equilibrium Pt-Sn(IMP) near-surface alloy with ca. 8.6 at% Sn. The surface composition was determined by low-energy ion-scattering (LEIS). The kinetics of the electrooxidation of CO and 2% CO/H₂ mixtures on Pt-Sn(IMP) is essentially identical to that of Pt₃Sn(110). The fact that any non-equilibrium composition can be easily prepared by this implantation method opens an interesting practical opportunity to create a new Pt-Sn alloy fuel cell catalyst having an otherwise unobtainable surface composition of Sn. This method also appears to have general utility in alloy catalysis as a means of exploring compositions in thermodynamically unfavorable regions of the bulk phase diagram. This revised version was published online in July 2006 with corrections to the Cover Date.     

An image watermarking based on the pdf modeling and quantization effects in the wavelet domain

An image watermarking technique based on the concept of JPEG2000 algorithm is proposed. Biorthogonal wavelet 9/7 transform is used to provide a set of coefficients suitable for watermark embedding. The statistical properties of different subbands are analyzed in order to choose the number of decomposition levels and position of subbands, which will assure the best compromise between the watermark transparency and robustness. The JPEG2000 quantization is applied to avoid insignificant wavelet coefficients, while the remaining ones are used for watermarking. The optimal and blind watermark detection is based on the nonlinear score function and appropriate model of coefficients distribution. The performance of the proposed procedure is tested on examples with various images, showing robustness under different attacks, while maintaining high image quality.     

Chemical correlates of α-tocopherol (Vitamin E) alteredMalacosoma disstria herbivory inFraxinus pennsylvanica var.Subintegerrinia,green ash

The antioxidant -tocopherol (vitamin E), applied in a basal trunk band to the green ash tree,Fraxinus pennsylvanica var.subintergerrinia, elicited an alteration of foliar feeding byMalacosoma disstria larvae (Lepidoptera: Lasiocampidae). The bioassayed effects were dependent on the dosage of elicitor, the time after elicitation, and the position in the tree. Leaves for chemical analysis were collected from trees receiving two dosages and at two intervals after elicitation. Compounds in the ethyl acetate extractables from the ash tree leaves were separated by TLC and HPLC. TLC separations showed differences in the nonhydrolyzed extractables attributable to elicitor dosage and time after elicitation. TLC-resolved differences were also evident among acid-hydrolyzed samples. HPLC-resolved profiles revealed eight peaks in the nonhydrolyzed extractables that were quantitatively negatively correlated with larval feeding preference between elicited versus control foliage on at least one of the two sampling dates. Results from this study and other investigations reported in the literature indicate that the antioxidant-tocopherol (vitamin E) can function as an environmental-stress elicitor of alterable defensive chemistry in green ash and other plants.     

Structural components in needle-cokes as studied by etching with chromic acid

Structures within commercial calcined needle-cokes are characterized by optical microscopy to reveal optical texture and by scanning electron microscopy before and after etching with chromic acid solution at 400 to 423 K. The needle-cokes exhibit an optical texture of medium and coarse-grained mosaics, acicular flow domains and flow domains. The etching studies indicate that the acicular flow domains are made up of rolled and convoluted lamellae which etch to form laths (needle-like) 3 m across. The mosaics appear when the rolled structures are viewed microscopically sectioned perpendicular to the lamellae. The acicular flow domains appear in longitudinal section. The etching of the flow domains shows that they have a sedimentary structure, 1 to 2 m layer thickness, suggesting that mesophase coalesces within a layer but not between layers. A model is proposed to explain the origin and separation of structures in needle-cokes as created in the delayed coker.     

An exact formula for "Tooth-to-Tooth" permeance

We present a new, completely original exact method to determine the permeance between two opposing iron teeth. This configuration is important because it is often encountered in electrical machines and apparatus. The method is based on conformal mapping. The given "tooth-to-tooth" configuration is mapped into a simpler one, in which the same permeance can be analytically determined. We derive an explicit formula for this permeance, and confirm our results using the finite-element method.