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Ohne Zusammenfassung 相似文献
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Less may not be more,but it still counts: The state of social capital in Yeoville,Johannesburg 总被引:2,自引:2,他引:0
Kirsten Harrison 《Urban Forum》2002,13(1):67-84
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Wardle Jane; Williamson Sara; Sutton Stephen; Biran Adam; McCaffery Kirsten; Cuzick Jack; Atkin Wendy 《Canadian Metallurgical Quarterly》2003,22(1):54
This article examines the psychological impact of participating in sigmoidoscopy screening for colorectal cancer prevention. The 1st study examined psychological well-being at 3 months, in relation to screening outcome, in 4,153 individuals. The 2nd study used longitudinal data to examine changes in psychological functioning from before to after screening in relation both to screening outcome and baseline indicators of vulnerability. There were few psychological differences between those who had received negative results or had polyps detected. These findings were confirmed in the longitudinal study, which also found no evidence for vulnerability to adverse effects among those who were initially most anxious or who perceived their risk of cancer to be higher. The longitudinal data suggested that screening might produce transient positive effects. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Ben-Porath Yossef S.; Hostetler Kirsten; Butcher James N.; Graham John R. 《Canadian Metallurgical Quarterly》1989,1(3):169
The development of three new content-homogeneous subscales for the revised Minnesota Multiphasic Personality Inventory (MMPI-2; J. N. Butcher et al, 1989) Social Introversion (Si) scale designed to replace the K. Serkownek (1975) subscales, which were not included in the revised MMPI, is described. The subscales, termed Shyness/Self-Consciousness, Social Avoidance, and Self/Other Alienation, were developed with data provided by college students (515 men and 797 women). Data analyses with this and the MMPI-2 normative sample demonstrated that the new subscales independently contribute to the assessment of nearly 90% of the variance in the full Si scale, that they display both convergent and divergent validity, and that these attributes generalize beyond the sample with which they were developed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Poly(diaryl diazosulfide)s and model diaryl diazosulfides of the general structure aryl-N?N? S-aryl' are tested for their thermostability. Thermolysis in solution is followed by means of UV spectroscopy. At the beginning of the decay most model diazosulfides follow first-order kinetics, but show an acceleration of the decay rate in the further course of the thermolysis. In contrast to the models the decomposition of the corresponding polymers cannot be described by first-order kinetics, except one example ( P 1 ). Thermogravimetry studies show weight losses of 8–12% in the range between 80 and 150°C depending on the structure of the models and polymeric diazosulfides. These values correspond with the content of azo function in these compounds, therefore it is assumed that nitrogen is split off under these reaction conditions. 相似文献
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Dr. Armin Welker Dr. Christian Kersten Dr. Christin Müller Dr. Ramakanth Madhugiri Collin Zimmer Patrick Müller Robert Zimmermann Stefan Hammerschmidt Hannah Maus Prof. John Ziebuhr Prof. Christoph Sotriffer Prof. Tanja Schirmeister 《ChemMedChem》2021,16(2):340-354
Inhibition of coronavirus (CoV)-encoded papain-like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure-activity relationships (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl) benzamide ( 2 b ), which is known to bind into the S3 and S4 pockets of the SARS-CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PLpro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS-CoV-2 replication in cell culture suggesting that, due to the high structural similarities of the target proteases, inhibitors identified against SARS-CoV PLpro are valuable starting points for the development of new pan-coronaviral inhibitors. 相似文献