全文获取类型
收费全文 | 88篇 |
免费 | 10篇 |
专业分类
化学工业 | 60篇 |
机械仪表 | 9篇 |
建筑科学 | 3篇 |
能源动力 | 5篇 |
水利工程 | 1篇 |
无线电 | 2篇 |
一般工业技术 | 12篇 |
自动化技术 | 6篇 |
出版年
2023年 | 2篇 |
2022年 | 12篇 |
2021年 | 14篇 |
2020年 | 2篇 |
2019年 | 2篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 5篇 |
2015年 | 1篇 |
2014年 | 2篇 |
2013年 | 6篇 |
2012年 | 8篇 |
2011年 | 6篇 |
2010年 | 11篇 |
2009年 | 5篇 |
2008年 | 3篇 |
2007年 | 1篇 |
2006年 | 3篇 |
2005年 | 1篇 |
2004年 | 1篇 |
2002年 | 2篇 |
2000年 | 1篇 |
1997年 | 1篇 |
排序方式: 共有98条查询结果,搜索用时 15 毫秒
1.
Amir Yair Danilov Claudiu Dolev Danny Kirsch Jonathan Lane John Nita-Rotaru Cristina Olsen Josh Zage David 《Dependable and Secure Computing, IEEE Transactions on》2010,7(1):80-93
This paper presents the first hierarchical Byzantine fault-tolerant replication architecture suitable to systems that span multiple wide-area sites. The architecture confines the effects of any malicious replica to its local site, reduces message complexity of wide-area communication, and allows read-only queries to be performed locally within a site for the price of additional standard hardware. We present proofs that our algorithm provides safety and liveness properties. A prototype implementation is evaluated over several network topologies and is compared with a flat Byzantine fault-tolerant approach. The experimental results show considerable improvement over flat Byzantine replication algorithms, bringing the performance of Byzantine replication closer to existing benign fault-tolerant replication techniques over wide area networks. 相似文献
2.
We consider left-invariant control affine systems, evolving on three-dimensional matrix Lie groups. Equivalence and controllability are investigated. All full-rank systems are classified, under detached feedback equivalence. A representative is identified for each equivalence class. The controllability nature of these representatives is determined. 相似文献
3.
4.
Dr. Andrea Angeli Prof. Marta Ferraroni Prof. Antonella Capperucci Dr. Damiano Tanini Prof. Gabriele Costantino Prof. Claudiu T. Supuran 《ChemMedChem》2022,17(11):e202200085
A study on the activity of selenocarbamates as a novel chemotype acting as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors is reported. Undergoing CA-mediated hydrolysis, selenocarbamates release selenolates behaving as zinc binding groups and effectively inhibiting CAs. A series of selenocarbamates characterised by high molecular diversity and complexity have been studied against different human CA isoforms such as hCA I, II, IX and XII. Selenocarbamates behave as masked selenols with potential biological applications as prodrugs for CAs inhibition-based strategies. X-ray studies provided insights into the binding mode of this novel class of CA inhibitors. 相似文献
5.
Gabriela Huminic Alexandru Vrdaru Angel Huminic Claudiu Fleac Florian Dumitrache Ion Morjan 《International journal of molecular sciences》2022,23(6)
In the current paper, a new hybrid nanofluid based on graphene oxide sheets and silicon nanoparticles is proposed for thermal applications. GO sheets and Si nanoparticles with different mixture ratios are dispersed in distilled water. Dynamic viscosity is measured at temperatures within the range 20–50 °C and the values are compared to the results available in the literature. The results indicated that the viscosity increases with increasing the mixture ratio of graphene oxide. A new correlation for the dynamic viscosity based on the experimental findings is proposed. Finally, the criteria for the performance of new hybrid nanofluid for thermal applications are analyzed. 相似文献
6.
Eva Havrnkov Vladimír Garaj rka Mascaretti Andrea Angeli Zuzana Soldnov Miroslav Kemka Jozef Moty
ka Marie Brzdov Jozef Csllei Josef Jampílek Claudiu T. Supuran 《International journal of molecular sciences》2022,23(1)
A series of 1,3,5-triazinyl aminobenzenesulfonamides substituted by aminoalcohol, aminostilbene, and aminochalcone structural motifs was synthesized as potential human carbonic anhydrase (hCA) inhibitors. The compounds were evaluated on their inhibition of tumor-associated hCA IX and hCA XII, hCA VII isoenzyme present in the brain, and physiologically important hCA I and hCA II. While the test compounds had only a negligible effect on physiologically important isoenzymes, many of the studied compounds significantly affected the hCA IX isoenzyme. Several compounds showed activity against hCA XII; (E)-4-{2-[(4-[(2,3-dihydroxypropyl)amino]-6-[(4-styrylphenyl)amino]-1,3,5-triazin-2-yl)amino]ethyl}benzenesulfonamide (31) and (E)-4-{2-[(4-[(4-hydroxyphenyl)amino]-6-[(4-styrylphenyl)amino]-1,3,5-triazin-2-yl)amino]ethyl}benzenesulfonamide (32) were the most effective inhibitors with KIs = 4.4 and 5.9 nM, respectively. In addition, the compounds were tested against vancomycin-resistant Enterococcus faecalis (VRE) isolates. (E)-4-[2-({4-[(4-cinnamoylphenyl)amino]-6-[(4-hydroxyphenyl)amino]-1,3,5-triazin-2-yl}amino)ethyl]benzenesulfonamide (21) (MIC = 26.33 µM) and derivative 32 (MIC range 13.80–55.20 µM) demonstrated the highest activity against all tested strains. The most active compounds were evaluated for their cytotoxicity against the Human Colorectal Tumor Cell Line (HCT116 p53 +/+). Only 4,4’-[(6-chloro-1,3,5-triazin-2,4-diyl)bis(iminomethylene)]dibenzenesulfonamide (7) and compound 32 demonstrated an IC50 of ca. 6.5 μM; otherwise, the other selected derivatives did not show toxicity at concentrations up to 50 µM. The molecular modeling and docking of active compounds into various hCA isoenzymes, including bacterial carbonic anhydrase, specifically α-CA present in VRE, was performed to try to outline a possible mechanism of selective anti-VRE activity. 相似文献
7.
Dr. Lilia Clima Bogdan Florin Craciun Dr. Andrea Angeli Andrea Petreni Alessandro Bonardi Dr. Alessio Nocentini Dr. Fabrizio Carta Prof. Paola Gratteri Prof. Mariana Pinteala Prof. Claudiu T. Supuran 《ChemMedChem》2020,15(21):2052-2057
We report novel molecules incorporating the nontoxic squalene scaffold and different carbonic anhydrase inhibitors (CAIs). Potent inhibitory action, in the low-nanomolar range, was detected against isoforms hCA II for sulfonamide derivatives, which proved to be selective against this isoform over the tumor-associate hCA IX and XII isoforms. On the other hand, coumarin derivatives showed weak potency but high selectivity against the tumor-associated isoform CA IX. These compounds are interesting candidates for preclinical evaluation in glaucoma or various tumors in which the two enzymes are involved. In addition, an in silico study of inhibitor-bound hCA II revealed extensive interactions with the hydrophobic pocket of the active site and provided molecular insights into the binding properties of these new inhibitors. 相似文献
8.
Sorption/release of diclofenac sodium in/from free‐standing poly(acrylic acid)/poly(ethyleneimine) multilayer films
下载免费PDF全文
![点击此处可从《应用聚合物科学杂志》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Polyelectrolyte multilayer films deposited onto various substrates have been used extensively as drug delivery systems. However, little attention has been paid to the release of drugs from free‐standing polymeric films. Herein, we report the construction of thermal crosslinked free‐standing poly(acrylic acid) (PAA)/branched poly(ethyleneimine) (PEI) multilayer films composed of 25 double layers [(PAA/PEI)25] and their use in sorption/release of diclofenac sodium (DS). The (PAA/PEI)25 multilayer films were characterized by scanning electron microscopy, potentiometric titrations and Fourier transform infrared spectroscopy, while the sorption/release of DS was monitored by UV – Vis spectroscopy. The DS sorption equilibrium data were fitted with five isotherm models (Langmuir, Freundlich, Sips, Dubinin–Radushkevich, and Temkin). The maximum equilibrium sorption capacity, qm, given by the Langmuir model was 32.42 mg DS/g. The Korsmeyer–Peppas semiempirical equation showed that the release of DS from the free‐standing (PAA/PEI)25 films proceeded by pseudo‐Fickian diffusion, irrespective of the releasing media. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43752. 相似文献
9.
10.