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排序方式: 共有159条查询结果,搜索用时 843 毫秒
1.
Heme oxygenase 1 is required for mammalian iron reutilization 总被引:1,自引:0,他引:1
Stressed mammalian cells up-regulate heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron. To assess the potential role of Hmox1 in cellular antioxidant defense, we analyzed the responses of cells from mice lacking functional Hmox1 to oxidative challenges. Cultured Hmox1(-/-) embryonic fibroblasts demonstrated high oxygen free radical production when exposed to hemin, hydrogen peroxide, paraquat, or cadmium chloride, and they were hypersensitive to cytotoxicity caused by hemin and hydrogen peroxide. Furthermore, young adult Hmox1(-/-) mice were vulnerable to mortality and hepatic necrosis when challenged with endotoxin. Our in vitro and in vivo results provide genetic evidence that up-regulation of Hmox1 serves as an adaptive mechanism to protect cells from oxidative damage during stress. 相似文献
2.
A Abeliovich C Chen Y Goda AJ Silva CF Stevens S Tonegawa 《Canadian Metallurgical Quarterly》1993,75(7):1253-1262
Calcium-phospholipid-dependent protein kinase (PKC) has long been suggested to play an important role in modulating synaptic efficacy. We have created a strain of mice that lacks the gamma subtype of PKC to evaluate the significance of this brain-specific PKC isozyme in synaptic plasticity. Mutant mice are viable, develop normally, and have synaptic transmission that is indistinguishable from wild-type mice. Long-term potentiation (LTP), however, is greatly diminished in mutant animals, while two other forms of synaptic plasticity, long-term depression and paired-pulse facilitation, are normal. Surprisingly, when tetanus to evoke LTP was preceded by a low frequency stimulation, mutant animals displayed apparently normal LTP. We propose that PKC gamma is not part of the molecular machinery that produces LTP but is a key regulatory component. 相似文献
3.
4.
Etsuo Yamamura 《Papers in Regional Science》1985,56(1):201-213
This paper reports on studies into the controllability of the regional income disparities arising from multi-regional economic growth. The necessary condition is that no significant band of regional income disparities should result at the end of the planning period. The regional disparities among nine regions in Japan are explored using the interregional input-output technique and regional production functions. Furthermore, some potentially interesting research probes into the controllability of regional income disparities using the reference adaptive control technique are discussed. 相似文献
5.
The complexation between poly(ethylene oxide) (PEO) and poly(acrylic acid) (PAA) was made by using double the molar quantity of either polymer component at pH 2 where the resulting complex completely precipitates. After the removal of the precipitate, PEO or PAA remaining in the supernatant was subjected to gel permeation chromatography to investigate the change in the molecular weight distribution (MWD) caused by the complexation. No remarkable difference is observed in the MWD curves for PEO[1] (Mw=1.37 × 104) before and after the complexation with PAA[1] (Mw=1.10 × 103) and PAA[2] (Mw=4.16 × 105). However, the MWD curves of PEO[2] (Mw=1.26 × 105) and PAA[2] become shortened and shift to the low molecular weight side after the complexation with PAA[1] or [2] and PEO[2], respectively. This tendency is enhanced by increasing the complexation temperature. From these results, it is indicated that the complexation between PEO and PAA deals with an equilibrium reaction, and the equilibrium constant is dependent on the chain length of both polymer components and also on the complexation temperature. 相似文献
6.
Stephen Matthew Lyth Huaiyu Shao Jianfeng Liu Kazunari Sasaki Etsuo Akiba 《International Journal of Hydrogen Energy》2014
Hydrogen storage is a crucial technology for the realization of a carbon-neutral society. However, few materials have been able to approach useful hydrogen storage capacity at reasonable temperatures and pressures. Graphene has an extremely high surface-area-to-weight ratio, is strong, cheap, chemically inert, and environmentally benign. As such it may be an ideal substrate for hydrogen storage. Here we present synthesis of graphene foam by combustion of sodium ethoxide. This technique is low-cost, scalable, and results in a three-dimensional graphene network with a surface area of more than 1200 m2/g. It is applied as a hydrogen storage material at liquid nitrogen temperature, with a capacity of 2.1 wt%. 相似文献
7.
Nitroxyl radicals are known to act as radical scavenging antioxidants. In the present study, a lipophilic nitroxyl radical,
cyclohexane-1-spiro-2′-(4′-oxyimidazolidine-1′-oxyl)-5′-spiro-1″-cyclohexane (nitroxyl radical I) was synthesized and its
antioxidant capacity was assessed in comparison with a hydrophilic nitroxyl radical, 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (Tempol). Both nitroxyl radical I and Tempol inhibited methyl linoleate oxidation induced by free radicals, and the
efficacy increased with decreasing partial pressure of oxygen, the effect being more pronounced for nitroxyl radical I than
Tempol. Their hydroxylamines inhibited lipid peroxidation more effectively than their corresponding parent nitroxyl radicals.
In liposomal membranes, a synergistic effect was observed in the combination of nitroxyl radical I with ascorbic acid, whereas
only an additive effect was observed between Tempol and ascorbic acid. The present study suggests that nitroxyl radical I
and its hydroxylamine may act as potent antioxidants, especially in combination with ascorbic acid under hypoxic conditions. 相似文献
8.
Miyanishi N Iwamoto Y Watanabe E Odaz T 《Journal of Bioscience and Bioengineering》2003,95(2):192-195
We prepared a beta-1,3-glucan oligomer (DP> or = 4) from laminarin (DP: 25-30) derived from Laminaria digitata with beta-1,3-glucanase, and examined its effect on human peripheral blood monocytes. Conditioned medium prepared by incubating monocytes (MC-CM) with the beta-1,3-glucan oligomer showed strong inhibitory activity against the proliferation of human leukemic U937 cells. Since the beta-1,3-glucan oligomer had no direct cytotoxic effect on U937 cells up to 1000 microg/ml, the cytotoxicity of the MC-CM may be due to cytotoxic cytokines produced from monocytes stimulated by the beta-1,3-glucan oligomer. On the other hand, the MC-CM prepared with original laminarin had little effect on the growth of U937 cells. The cytotoxicity of the MC-CM prepared with the beta-1,3-glucan oligomer was significantly reduced by an anti-TNF-alpha antibody, but the anti-TNF-beta antibody had no effect. Our results suggest that the enzymatically depolymerized beta-1,3-glucan oligomer induces TNF-alpha production from human monocytes. 相似文献
9.
10.
M Xu TE Koeltzow GT Santiago R Moratalla DC Cooper XT Hu NM White AM Graybiel FJ White S Tonegawa 《Canadian Metallurgical Quarterly》1997,19(4):837-848
The dopamine D3 receptor is expressed primarily in regions of the brain that are thought to influence motivation and motor functions. To specify in vivo D3 receptor function, we generated mutant mice lacking this receptor. Our analysis indicates that in a novel environment, D3 mutant mice are transiently more active than wild-type mice, an effect not associated with anxiety state. Moreover, D3 mutant mice exhibit enhanced behavioral sensitivity to combined injections of D1 and D2 class receptor agonists, cocaine and amphetamine. However, the combined electrophysiological effects of the same D1 and D2 agonists on single neurons within the nucleus accumbens were not altered by the D3 receptor mutation. We conclude that one function of the D3 receptor is to modulate behaviors by inhibiting the cooperative effects of postsynaptic D1 and other D2 class receptors at systems level. 相似文献