Comparison of PF4/heparin ELISA assay with the 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia

The diagnosis of heparin-induced thrombocytopenia (HIT) may be affirmed by demonstrating heparin-dependent anti-platelet antibodies using the 14C-serotonin release assay (SRA). In this study, results of the SRA was compared with the recently described platelet factor 4 (PF4)/heparin enzyme-linked immunosorbent assay (ELISA). Compared with the SRA, the sensitivity and specificity of a PF4/heparin ELISA was 87% and 92%, respectively, using an assay developed in our laboratory; and 90% and 98%, respectively, using a commercially developed kit (Diagnostica Stago, Asnieres, France). However, antibodies to PF4/heparin were also detected in up to 8% of patients whose plasma was negative by SRA, and 23% of patients receiving heparin who were not thrombocytopenic. These data indicate that results obtained with the PF4/heparin ELISA and the SRA are generally in accord in patients with a clinical diagnosis of HIT. However, discrepant results occur in approximately 20% of cases because of the greater sensitivity of ELISA and the possible involvement of other heparin-binding proteins. The fact that each assay contributes independent information in some cases must be considered in the sequence of test performance and in providing consultation to the practicing hematologist.     

Qualitative response of safety injection system for a large size break in the reactor coolant system cold leg

Safety injection system, accumulator injection system and residual heat removal system of CHASNUPP-1 were simulated using the computer code APROS. We observed the qualitative response of the simulated system during injection and re-circulation phases after LOCA. During rapid depressurization of SRC system due to leakage, these systems started coolant injection in the SRC system as per plant requirement. Different thermal-hydraulic parameters of the respective systems are presented and discussed. Results obtained are in good agreement with the reported document of the reference power plant.     

Energy-efficient clustering in mobile ad-hoc networks using multi-objective particle swarm optimization

A mobile ad hoc network (MANET) is dynamic in nature and is composed of wirelessly connected nodes that perform hop-by-hop routing without the help of any fixed infrastructure. One of the important requirements of a MANET is the efficiency of energy, which increases the lifetime of the network. Several techniques have been proposed by researchers to achieve this goal and one of them is clustering in MANETs that can help in providing an energy-efficient solution. Clustering involves the selection of cluster-heads (CHs) for each cluster and fewer CHs result in greater energy efficiency as these nodes drain more power than noncluster-heads. In the literature, several techniques are available for clustering by using optimization and evolutionary techniques that provide a single solution at a time. In this paper, we propose a multi-objective solution by using multi-objective particle swarm optimization (MOPSO) algorithm to optimize the number of clusters in an ad hoc network as well as energy dissipation in nodes in order to provide an energy-efficient solution and reduce the network traffic. In the proposed solution, inter-cluster and intra-cluster traffic is managed by the cluster-heads. The proposed algorithm takes into consideration the degree of nodes, transmission power, and battery power consumption of the mobile nodes. The main advantage of this method is that it provides a set of solutions at a time. These solutions are achieved through optimal Pareto front. We compare the results of the proposed approach with two other well-known clustering techniques; WCA and CLPSO-based clustering by using different performance metrics. We perform extensive simulations to show that the proposed approach is an effective approach for clustering in mobile ad hoc networks environment and performs better than the other two approaches.     

Interpretation of way-finding healthcare symbols by a multicultural population: Navigation signage design for global health

The interpretation of way-finding symbols for healthcare facilities in a multicultural community was assessed in a cross-sectional study. One hundred participants recruited from Al Ain city in the United Arab Emirates were asked to interpret 28 healthcare symbols developed at Hablamos Juntos (such as vaccinations and laboratory) as well as 18 general-purpose symbols (such as elevators and restrooms). The mean age was 27.6 years (16–55 years) of whom 84 (84%) were females. Healthcare symbols were more difficult to comprehend than general-purpose signs. Symbols referring to abstract concepts were the most misinterpreted including oncology, diabetes education, outpatient clinic, interpretive services, pharmacy, internal medicine, registration, social services, obstetrics and gynecology, pediatrics and infectious diseases. Interpretation rates varied across cultural backgrounds and increased with higher education and younger age. Signage within healthcare facilities should be tested among older persons, those with limited literacy and across a wide range of cultures.     

A secure image encryption scheme based on chaotic maps and affine transformation

Due to the interesting nonlinear dynamic properties of chaotic maps, recently chaos-based encryption algorithms have gained much attention in cryptographic communities. However, many encryption schemes do not fulfil the minimum key space requirement, which is an essential concern in many secure data applications. In this paper, an efficient chaos-based image encryption scheme with higher key space is presented. Even with a single round of encryption, a significantly larger key space can be achieved. The proposed scheme removes correlation among image pixels via random chaotic sequences, simply by XOR and addition operations. In order to resist against numerous attacks, we apply the affine transformation to get the final ciphertext image. The security of the proposed scheme is proved through histogram, contrast, PSNR, entropy, correlation, key space, key sensitivity and differential attack analysis. Many significant properties of chaotic maps, sensitivity to initial condition and control parameters, structure and attack complexity, make the anticipated scheme very reliable, practical and robust in various secure communication applications.     

Coordinated design of TCSC and PSS controllers using VURPSO and Genetic algorithms for multi-machine power system stability

Thyristor controlled series capacitor (TCSC) can regulate line impedance and therefore increase transferred power of the system. On the other hand power system stabilizer (PSS) increases dynamic stability of generator. To enhance the stability, combination of TCSC and PSS can be applied, and in such a case coordination of TCSC and PSS is essential. This paper applies this combined controller in order to enhance the stability of multi-machine system. Parameters of these controllers are optimized by velocity update relaxation particle swarm optimization (VURPSO) algorithm and Genetic algorithm (GA). The simulation results show that the combination of VURPSO algorithm and GA leads to a better design and stability.     

Your comments matter: incorporating viewers’ comments for ranking online video content using bibliometrics

ABSTRACT

The quality of user-generated content over World Wide Web media is a matter of serious concern for both creators and users. To measure the quality of content, webometric techniques are commonly used. In recent times, bibliometric techniques have been introduced to good effect for evaluation of the quality of user-generated content, which were originally used for scholarly data. However, the application of bibliometric techniques to evaluate the quality of YouTube content is limited to h-index and g-index considering only views. This paper advocates for and demonstrates the adaptation of existing Bibliometric indices including h-index, g-index and M-index exploiting both views and comments and proposes three indices h_vc, g_vc and m_vc for YouTube video channel ranking. The empirical results prove that the proposed indices using views along with the comments outperform the existing approaches on a real-world dataset of YouTube.     

Adaptive dynamic surface control of a hypersonic flight vehicle with improved tracking

This work presents a nonlinear adaptive dynamic surface air speed and a flight path angle control design procedure for the longitudinal dynamics of a generic hypersonic flight vehicle. The proposed design scheme takes into account the magnitude, rate, and bandwidth constraints on the actuator signals. A new approach is used to enhance tracking performance and avoid a large initial control signal. The uncertain nonlinear functions in the flight vehicle model are approximated by using radial basis function neural networks. A detailed stability analysis of the designed controllers shows that all the signals of the closed‐loop system are uniformly ultimately bounded. The robust performance of the design scheme is verified through numerical simulations of the flight vehicle model for various parameter variation test cases. Copyright © 2011 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society     

Investigating the effect of varying block size on power and energy consumption of GPU kernels

The Journal of Supercomputing - Power consumption is likely to remain a significant concern for exascale performance in the foreseeable future. In addition, graphics processing units (GPUs) have...     

Evaluating Six Sigma failure rate for inverse Gaussian cycle times

Six Sigma is a quality philosophy and methodology that aims to achieve operational excellence and delighted customers. The cost of poor quality depends on the sigma quality level and its corresponding failure rate. Six Sigma provides a well-defined target of 3.4 defects per million. This failure rate is commonly evaluated under the assumption that the process is normally distributed and its specifications are two-sided. However, these assumptions may lead to implementation of quality-improvement strategies that are based on inaccurate evaluations of quality costs and profits. This paper defines the relationship between failure rate and sigma quality level for inverse Gaussian processes. The inverse Gaussian distribution has considerable applications in describing cycle times, product life, employee service times, and so on. We show that for these processes attaining Six Sigma target failure rate requires higher quality efforts than for normal processes. A generic model is presented to characterise cycle times in manufacturing systems. In this model, the asymptotic production is described by a drifted Brownian motion, and the cycle time is evaluated by using the first passage time theory of a Wiener process to a boundary. The proposed method estimates the right efforts required to reach Six Sigma goals.