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Kostyantyn Volyanskyy Wassim M. Haddad James M. Bailey 《International Journal of Adaptive Control and Signal Processing》2009,23(1):1-29
Compartmental system models involve dynamic states whose values are nonnegative. These models are widespread in biological and physiological sciences and play a key role in understanding these processes. In this paper, we develop a direct adaptive disturbance rejection control framework for compartmental dynamical systems with exogenous bounded disturbances. The proposed framework is Lyapunov based and guarantees partial asymptotic stability of the closed‐loop system, that is, asymptotic stability with respect to part of the closed‐loop system states associated with the plant dynamics. The remainder of the states associated with the adaptive controller gains are shown to be Lyapunov stable. In the case of bounded energy ??2 disturbances, the proposed approach guarantees a nonexpansivity constraint on the closed‐loop input–output map between the plant disturbances and performance variables. Finally, a numerical example involving the infusion of the anesthetic drug propofol for maintaining a desired constant level of depth of anesthesia for surgery in the face of continuing hemorrhage and hemodilution is provided. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
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Kostyantyn Y. Volyanskyy Wassim M. Haddad James M. Bailey 《International Journal of Adaptive Control and Signal Processing》2011,25(6):483-501
A neuroadaptive output feedback control architecture for nonlinear nonnegative dynamical systems with input amplitude and integral constraints is developed. Specifically, the neuroadaptive controller guarantees that the control amplitude as well as the integral of the control input over a given time interval are constrained, and the physical system states remain in the nonnegative orthant of the state space. The proposed approach is used to control the infusion of the anesthetic drug propofol for maintaining a desired constant level of depth of anesthesia for noncardiac surgery in the face of infusion rate constraints and an integral drug dosing constraint over a specified time period. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
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Improvement of jet technology for soil stabilization 总被引:1,自引:0,他引:1
I. I. Broid V. P. Drobadenko N. G. Malukhin 《Soil Mechanics and Foundation Engineering》1997,34(6):197-200
A geotechnology is described for soil stabilization on the basis of an improved design of jet monitor, which makes it possible
to change the traditional procedural process and mix soil with grout on the surface; this makes it possible to save significantly
on cementing materials, and also to completely replace the natural soil with a hardening grout or another soil.
Translated from Osnovaniya, Fundamenty i Mekhanika Gruntov, No. 6, pp. 19–22, November–December, 1997. 相似文献
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Dmytro Bratiichuk Olena Kurylenko Roksolana Vasylyshyn MingXing Zuo Yingqian Kang Kostyantyn Dmytruk Andriy Sibirny 《Yeast (Chichester, England)》2020,37(9-10):505-513
Nonconventional yeast Candida famata and Ogataea polymorpha are interesting organisms for basic and applied studies. O. polymorpha is methylotrophic thermotolerant yeast capable of xylose alcoholic fermentation whereas C. famata is capable of riboflavin overproduction. Still, the new tools for molecular research of these species are needed. The aim of this study was to develop the new dominant selective markers for C. famata and O. polymorpha usable in metabolic engineering experiments. In this work, the BSD gene from Aspergillus terreus coding for blasticidin S deaminase, O. polymorpha AUR1 gene required for sphingolipid synthesis and IMH3 gene, which encodes IMP dehydrogenase, were tested as the new dominant selective marker genes. Our results showed that AUR1 and IMH3 genes could be used as dominant selective markers for O. polymorpha with frequencies of transformation of 40 and 20 transformants per microgram of DNA, respectively. The IMH3 gene was successfully used as the marker for construction of O. polymorpha strains with increased ethanol production from xylose due to overexpression of TAL1, TKL1 and AOX1 genes. The BSD gene from A. terreus, conferring resistance to blasticidin, was found to be efficient for selection of C. famata transformants. 相似文献
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Marta Semkiv Iwona Kata Orysya Ternavska Wladimir Sibirny Kostyantyn Dmytruk Andriy Sibirny 《Yeast (Chichester, England)》2019,36(5):329-339
Production of fuel ethanol is one of the possible ways to utilize crude glycerol, substantial amounts of which are produced by biodiesel industry. Earlier, we have described construction of the recombinant strains of methylotrophic thermotolerant yeast Ogataea polymorpha with simultaneous overexpression of the genes PDC1 and ADH1, which produced increased amounts of ethanol from glycerol. In this work, we have further improved these strains by overexpression of genes involved either in oxidative (through dihydroxyacetone) or phosphorylative (through glycerol-3-phosphate) pathway of glycerol catabolism, as well as heterologous gene coding for glycerol transporter FPS1 from Komagataella phaffii (formerly, Pichia pastoris). Obtained recombinant strains produced up to 10.7 g/L of ethanol (with ethanol productivity 30 mg/g of biomass/hr and yield 132 mg/g of consumed glycerol) from pure glycerol and up to 3.55 g/L of ethanol (with ethanol productivity 11.6 mg/g of biomass/hr and yield 72.3 mg/g of consumed glycerol) from crude glycerol as a carbon source, which is approximately 15 times more relative to that of the O. polymorpha wild-type strain and 2.2 more relative to the earlier constructed strain. 相似文献
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Candida famata (Candida flareri) belongs to the group of so‐called ‘flavinogenic yeasts’, capable of riboflavin oversynthesis under condition of iron starvation. Some strains of C. famata belong to the most flavinogenic organisms known and were used for industrial production of riboflavin for a long time in the USA. C. famata is characterized by high salt tolerance, growing at NaCl concentrations of up to 2.5 m . Development of basic tools for the metabolic engineering of C. famata, such as a transformation system, selective markers, insertional mutagenesis, a reporter system and others, are described. The developed tools were used for cloning and identification of structural and regulatory genes of riboflavin synthesis. The construction of improved yeast strains producing riboflavin, FMN and FAD, based on the industrial riboflavin‐producing strain dep8 and its non‐reverting analogue AF4, is also described. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
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Michail V. Burmistr Kostyantyn M. Sukhyy Valery V. Shilov Policarpos Pissis Anna Spanoudaki Irina V. Sukha Vitalij I. Tomilo Yuri P. Gomza 《Polymer》2005,46(26):139-12232
Polymer–clay composites has been prepared by melt blending an organo-bentonite with linear polymers (polyamide, polysterene and polypropylene) in a disk-screw extruder. In first time organo-clay was prepared by surface treatment of Na-forms bentonite with polymeric quaternary ammonium salts (PQAS). XRD indicated that organo-bentonite layers were exfoliated and dispersed into polyamide and polystyrene. Addition of 2 wt% organo-bentonites (optimal concentration) to polyamide increased tensile strength by 53% and Sharpy impact by 140%. With the incorporation of 2 wt% organo-bentonites (optimal concentration) into polystyrene the tensile strength increased to 28% and the Sharpy impact increased to 25%. For polypropylyne–organo-bentonites composites we did not observe delamination of layered structure, and as result absence of reinforcements. TGA showed that the polyamide and polystyrene nanocomposites have higher decomposition temperature in comparison with the original polymers. 相似文献
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In this study, a mechanistic approach using elementary cutting tool (ECT) edges of varying inclination and normal rake angles is demonstrated to be capable to predict hollow needle insertion force. A needle force model is developed and validated for the specific case of 11 gauge two-plane symmetric needles. Blades of varying inclination and rake angles are inserted into bovine liver to determine the specific force of initial tissue cutting for the given edge geometry; this information is applied to the ECT force model which is validated against experimental force results of hollow needles inserted into bovine liver. 相似文献