Pulmonary vascular disease and operative indications in complete atrioventricular canal defect in early infancy

Pulmonary vascular disease was morphometrically analyzed in 67 patients (mean age, 19 months) with isolated complete atrioventricular canal defect. Complete obstruction of the small pulmonary arterial lumen resulting from acute fibrous proliferation and atrophy of the peripheral arterial media, which were considered absolute operative contraindications, were characteristic in six patients with Down's syndrome. Morphometric analysis of medial thickness revealed that thinning of the media of the small pulmonary arteries is generally observed at around 6 months of age in patients with complete atrioventricular canal defect and that the media in patients who have complete atrioventricular canal defect and Down's syndrome was thinner than that in such patients without Down's syndrome. These results suggest that thinning of the media as a result of two factors--Down's syndrome and aging--facilitates the rapid occurrence of fibrous intimal proliferation. Therefore intracardiac repair is desirable within 6 months of life, before medial thinning, in patients with complete atrioventricular canal defect and Down's syndrome. Excluding patients with absolute operative contraindications, the scores of the index of pulmonary vascular disease in operative survivors were below 2.0 and death occurred when scores were more than 2.2. The pulmonary vascular resistances measured in room air and by the oxygen inhalation and tolazoline tests in patients with operative contraindications were more than 7.3, 3.8, and 6.6 units.m2, respectively. We thus conclude that lung biopsy should be undertaken for patients in whom pulmonary vascular resistance is beyond these values to determine the appropriateness of surgical intervention.     

Investigation on the viscoelasticity of optical glass in ultraprecision lens molding process

Glass molding press is an efficient manufacturing technology for ultraprecision optical elements with complex shapes. In glass molding, viscoelastic property of glass is an essential aspect that determines the glass deformation behavior around the molding temperature. In this paper, viscoelasticity of glass has been measured experimentally by uniaxially compressing cylindrical glass preforms above the glass transition temperature using an ultraprecision glass molding machine. The elastic modulus and viscosity of glass were obtained by curve fitting techniques using the Burgers model and the Maxwell model for creep and stress relaxation, respectively. Based on the thermo mechanical and viscoelastic parameters obtained from experiments, finite element model simulations of the glass molding process were performed, which can be used to visualize the stress/strain distribution and to predict the residual stress in glass.     

Subtotal cor triatrium with left partial anomalous pulmonary venous connection--successful correction in an infant

This report concerns a 10-month-old infant with subtotal cor triatrium associated with left sided partial anomalous pulmonary venous connection to the innominate vein. In the operation, we found that the fossa ovalis existed between the right atrium and the accessory atrial chamber. We performed a radical operation which consisted of a resection of the intra-left-atrial diaphragma and a anastomosis of the vertical vein to the left atrium. His postoperative course was uneventful, and the result was satisfactory. We have presented and reviewed our case, and then discussed the embryogenesis and the hemodynamics. To our knowledge, our case represents the first successful surgical repair of this combination of defects in Japan.     

Investigation on shape transferability in ultraprecision glass molding press for microgrooves

Glass molding press (GMP) has been applied to produce the microgrooves on glass plates by using electroless-plated nickel phosphorus (Ni-P) molds. The GMP process for microgrooves was analyzed by finite element method (FEM) simulation. The effects of various pressing conditions, such as the molding temperature, the pressing velocity and the friction in glass deformation, were studied. Then, based on the simulation results, optimal pressing conditions were determined and used in the GMP experiments. By comparing the shape of the molded microgrooves with that of the corresponding microgrooves on the Ni-P mold, the shape transferability was evaluated and the reasons for form error were analyzed. The results show that the GMP process is an effective way to fabricate precision microgrooves on glass.     

Surgical therapy in a case of congenital mitral valve insufficiency]

Using sheep erythrocytes (SRBC) as the antigen, two subpopulations of spleen antigen-binding lymphocytes could be distinguished by a marked difference in the susceptibility of their receptors to trypsin. In unimmunized animals, 30% of the antigen-binding cells were trypsin-resistant, whereas at 5 days after immunization, 80-90% were trypsin-resistant, indicating an increase of about 50-fold in trypsin-resistant antigen-binding cells per spleen. In contrast, trypsin-sensitive cells per spleen were only 4-fold higher on day 5 than before immunization. The rise in % trypsin sensitivity preceded the increase in rosettes per spleen, implying that immunization produced a preferential increase in trypsin-resistant antigen binding cells partly by converting sensitive cells to resistant cells. After the 5th day, the trypsin sensitivity of antigen-binding cells slowly returned toward the unimmunized level, but a booster injection of SRBC restored trypsin resistance. Trypsin resistance was not lost in the presence of sodium azide or protein synthesis inhibitors. But a slightly increased trypsin susceptibility was conferred by 2-deoxyglucose, implying that glycolysis or the glycosylation of protein may be involved in maintaining trypsin resistance.     

Fabricating microgrooves with varied cross-sections by electrodischarge machining

A two-step electrodischarge machining method was proposed for fabricating microgrooves with varied cross-sections on hard materials. Firstly, tungsten tool electrodes were shaped by wire electrodischarge grinding, and then the resulting tool electrodes were used to electrodischarge machine microgrooves on stainless steel. Preliminary experimental results showed that, in the first step, a sharp tool electrode with surface roughness of 0.3 µmRa could be achieved, and the surface roughness of the resulting groove was 0.16 µmRa in the second step. Voltage strongly affects the machining speed. A high voltage (>70 V) was preferable for improving the material removal rate. However, significant tool wear took place when using a high condenser capacitance at high voltages. To suppress tool wear, a high voltage and a small capacitance should be used. As test pieces, microgrooves having rectangular, triangular, circular and semi-closed cross-sections were fabricated.     

Investigation of internal ultrasonically assisted grinding of small holes: effect of ultrasonic vibration in truing and dressing of small CBN grinding wheel

In internal grinding of small holes, it is hard to realize high accuracy truing and dressing for the grinding wheel when a conventional truing/dressing method using single diamond dresser or rotary cup wheel is employed. Because of the cantilever support condition of the spindle shaft the stiffness of shaft is reduced. Thus the truing force leads the shaft to a significant deformation during truing/dressing. In this study, for improving the truing and dressing accuracy, a new truing/dressing method was proposed, in which the grinding wheel is ultrasonically vibrated along its axis during truing/dressing with a GC rotary cup wheel. A series of experiments were carried out to investigate the effects of the wheel ultrasonication on the truing force reduction, the truing accuracy improvement and the wheel surface condition. In addition, the grinding force and work surface roughness experimentally obtained by using the wheels trued with or without ultrasonication were compared. The experimental results indicated that applying ultrasonic vibration to the wheel decreases the normal and tangential grinding forces by more than 20% and 24%, respectively, and the surface roughness by as much as 18%.     

Carbon nanofiber assisted micro electro discharge machining of reaction-bonded silicon carbide

Carbon nanofiber assisted micro electro discharge machining was proposed and experiments were performed on reaction-bonded silicon carbide. The changes in electro discharging behavior, material removal rate, electrode wear ratio, electrode geometry, spark gap, surface finish, surface topography and surface damage with carbon nanofiber concentration were examined. It has been found that the addition of carbon nanofiber not only improves the electro discharge frequency, material removal rate, discharge gap, but also reduces the electrode wear and electrode tip concavity. Bidirectional material migrations between the electrode and the workpiece surface were detected, and the migration behavior was strongly suppressed by carbon nanofiber addition. Adhesion of carbon nanofibers to the workpiece surface occurs, which contributes to the improvement of electro discharge machinability. These findings provide possibility for high-efficiency precision manufacturing of microstructures on ultra-hard ceramic materials.     

Analysis of machinable structures and their wettability of rotary ultrasonic texturing method

Tailored surface textures at the micro- or nanoscale dimensions are widely used to get required functional performances. Rotary ultrasonic texturing (RUT) technique has been proved to be capable of fabricating periodic micro- and nanostructures. In the present study, diamond tools with geometrically defined cutting edges were designed for fabricating different types of tailored surface textures using the RUT method. Surface generation mechanisms and machinable structures of the RUT process are analyzed and simulated with a 3D-CAD program. Textured surfaces generated by using a triangular pyramid cutting tip are constructed. Different textural patterns from several micrometers to several tens of micrometers with few burrs were successfully fabricated, which proved that tools with a proper two-rake-face design are capable of removing cutting chips efficiently along a sinusoidal cutting locus in the RUT process. Technical applications of the textured surfaces are also discussed. Wetting properties of textured aluminum surfaces were evaluated by combining the test of surface roughness features. The results show that the real surface area of the textured aluminum surfaces almost doubled by comparing with that of a flat surface, and anisotropic wetting properties were obtained due to the obvious directional textural features.