Status of Work on the VÉPP-5 Injection Complex

The VÉPP-5 injection complex under construction at the Institute of Nuclear Physics of the Siberian Branch of the Russian Academy of Sciences is a powerful source of intense electron and positron bunches at 510 MeV, which covers all needs of the electron–positron colliding beam setups currently operating and under construction at the Institute of Nuclear Physics. The complex includes a 285 MeV linear electron accelerator, a 510 MeV linear positron accelerator, and an accumulator–cooler with beam injection and ejection channels. Intense work on the design, assembly, and tuning of the linear electron accelerator has been conducted in the last 2 yr. As a result, by August 2002 the linear electron accelerator was put into operation with all standard subsystems. By this time, the isochronous achromatic turning of the electron beam, a system for converting electrons into positrons, and the first accelerating structure of the linear positron accelerator were assembled and put into operation. All this made it possible to accelerate the positron beam up to 75 MeV. Preliminary results of tests of the linear accelerators are presented.     

Design of Roller Beams Using SolidWorks Software

Russian Engineering Research - Roller beams are investigated by the finite-element method, using SolidWorks Simulation software. Static analysis of the beam’s stress–strain state...     

An adenoviral platform for selective self-assembly and targeted delivery of nanoparticles

Metallic nanoparticles (NPs) can be used for the diagnosis, imaging, and therapy of tumors and cardiovascular disease. However, targeted delivery of NPs to specific cells remains a major limitation for clinical realization of these potential treatment options. Herein, a novel strategy for the specific coupling of NPs to a targeted adenoviral (Ad) platform to deliver NPs to specific cells is defined. Genetic manipulation of the gene-therapy vector is combined with a specific chemical coupling strategy. In particular, a high-affinity interaction between a sequence of six-histidine amino acid residues genetically incorporated into Ad capsid proteins and nickel(II) nitrilotriacetic acid on the surface of gold NPs is employed. The selective self-assembly of gold NPs and Ad vectors into multifunctional platforms does not negatively affect the targeting of Ad to specific cells. This opens the possibility of using Ad vectors for targeted NP delivery, thereby providing a new type of combinatorial approach for the treatment of diseases that involves both nanotechnology and gene therapy.