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排序方式: 共有188条查询结果,搜索用时 31 毫秒
1.
I Miura A Ohshima N Takahashi K Hashimoto T Nimura S Utsumi M Saito T Miki S Hirosawa AB Miura 《Canadian Metallurgical Quarterly》1996,64(3-4):249-256
We describe two cases of non-Hodgkin's lymphoma associated with t(3;6)(q27;p21.3) and BCL6 rearrangement. The first case was in a 78-year old woman, whose performance status (PS) was 1, the serum lactate dehydrogenase (LDH) level was elevated, and the Ann Arbor stage was IIIA with no extra nodal lymphomatous site. The pathological diagnosis from a biopsy of the inguinal lymph node was 'malignant lymphoma (ML), follicular, small cleaved' according to the Working Formulation. Complete remission was achieved. Although she had relapse in 1992, remission was obtained again. The second case was in a 62-year old man, whose PS was 1, the serum LDH was normal, and Ann Arbor stage was IVA with the involvement of the small intestine. Histological diagnosis of the cervical lymph node was 'ML, diffuse, large cell'. Complete remission was obtained without relapse. The 3q27 translocations, found in 20-30% of non-Hodgkin's lymphoma, are unique in having multiple chromosomal translocation partners. Chromosome band 6p21.3 is one of these partner sites that may be the site of a novel gene. The two cases presented here show that this translocation is a non-random chromosomal change involving 3q27 and BCL6. Since t(3;6) was the sole karyotypic abnormality in one case, this translocation may play a role in lymphomagenesis. 相似文献
2.
Toshio Kimura Yoshikatu Okada Takashi Yamaguchi Yuzo Shimada Kazuaki Utsumi 《The Journal of Adhesion》1994,47(1):179-190
Bondability and interfacial reaction between dielectric and insulator layers have been examined to obtain a basic understanding of bonding mechanisms. Lead-containing complex perovskite was used as a dielectric material. Two kinds of glass-ceramics were used as insulator material; lead borosilicate glass containing Al2O3 (insulator A) and the same containing Al2O3 and MgO (insulator B). Dielectric and insulator layers did not bond when insulator A was used. When insulator B was used, however, strong bonding was achieved between the two layers by firing the powder compacts at temperatures between 800° and 1000°C. Addition of MgO to lead borosilicate glass increased the thermal expansion coefficient to that of the dielectric and enhanced the formation of reaction layers, resulting in good bonding. Two reaction layers were identified. The main reaction products were enstatite and bredigite for one layer contacting the dielectric, and enstatite and a compound with the same diffraction pattern as that of faujasite for the other layers contacting insulator B. 相似文献
3.
The effect of the N-linked glycans on structural features and physicochemical functions of soybean β-conglycinin homotrimers 总被引:2,自引:0,他引:2
Nobuyuki Maruyama Mohamad Ramlan Mohamed Salleh Koji Takahashi Kazuhiro Yagasaki Hideyuki Goto Naho Hontani Shuko Nakagawa Shigeru Utsumi 《Journal of the American Oil Chemists' Society》2002,79(2):139-144
β-Conglycinin is a trimeric protein consisting of three subunits, α,α′,and β, which are N-glycosylated. The α and α′ subunits
contain extension regions in addition to core regions common to all subunits. We purified homogeneous trimers consisting of
only α, α′, or β from mutant soybean cultivars containing β-conglycinin lacking one or two subunits: α homotrimers from an
α′-lacking mutant, α′ homotrimers from an α-lacking mutant, and β homotrimers from an α-and α′-lacking mutant. Structural
features and physicochemical functions of the three homotrimers were examined and compared with those of recombinant homotrimers
having no N-linked glycans. The native homotrimers have secondary structures very similar to those of the recombinant ones.
In analogy with the recombinant homotrimers, the native ones exhibit different thermal stabilities from one another (β>α′>α),
and the native α and α′ homotrimers exhibit better solubility, emulsifying ability, and heat-induced association than the
native β homotrimer. Further, the N-linked glycans contribute to solubilities of the three subunits at low ionic strength
(μ=0.08) and to the emulsifying ability of the native β homotrimer. N-Linked glycans also prevent heat-induced associations
of the native α and α′ homotrimers but do not contribute to the secondary structure and the thermal stability of β-conglycinin. 相似文献
4.
Yoshiaki Ukita Kazuhiro Kanda Shinji Matsui Mitsuyoshi Kishihara Yuichi Utsumi 《Microsystem Technologies》2008,14(9-11):1567-1572
Polytetrafluoroethylene (PTFE) microstructures’ processing characteristics using X-ray photo dcomposition and desorption are studied in the highest energy region (2 keV to >12 keV). While the exposed surface states are seen melting and boiling from the remaining bubble structure of the irradiated surface, basic photochemistry of PTFE is also same as previous reports and high-aspect ratio structures are successfully formed. We developed new Ni stencil electroformed stencil masks and successfully fabricated first and practical example of PTFE micro fluidic parts. The characteristics of fabricated micro fluidic parts, a PTFE fluid filter for vertical fluid flow operation which works as passive valve, agreed with the calculated results. This suggests that the accuracy of patterning is adequate to apply this technique to fabricate microfluidic parts and other various microparts. 相似文献
5.
Yoshiaki Ukita Toshifumi Asano Kuniyo Fujiwara Katsuhiro Matsui Masahiro Takeo Seiji Negoro Yuichi Utsumi 《Microsystem Technologies》2008,14(9-11):1573-1579
The advantages of vertical microreactor stack with three-dimensional (3D) structure for immunoassay are discussed. The vertical microreactor stack uses vertical fluid flow operation with multifunctional fluid filters. The multi function of fluid filter is very effective for micromixing and passive valve operation. The mechanism of micromixing is discussed by using computational fluid dynamics (CFD), and we know that the mixing mechanism based on Coanda effect. To evaluate the micromixing performance of fluid filter, we demonstrated enzyme reaction with unique repeat mixing operation. As the results, we proved that the fluid filter has very effective mixing performance. The detection limit, which demonstrated by competition enzyme-linked immunosorvent assay (ELISA), is comparable with recommended detection limit, which suggested by Japanese ministry for the environment. 相似文献
6.
K. Fujiwara Y. Ukita M. Takeo S. Negoro T. Kanie M. Katayama Y. Utsumi 《Microsystem Technologies》2008,14(9-11):1411-1416
A novel type passive mixing device that causes the three-dimensional flow was proposed. This mixer consists of the integrated capillary bundle structure. And the capillaries ware cross-linked each other. So it is called cross-linked micro capillary filter. The mixing effect of the cross-linked micro capillary filter was calculated by the computational fluid dynamics (CFD). The fluid behaviour in the fine three-dimensional structure could be analysed by the use of CFD. In the result of CFD calculation, the cross-linked micro capillary filter estimated high mixing effect. Moreover, the mixing efficiency was become higher by change the cross-linked form. The calculation result was decided the form of the cross-linked micro capillary filter. And this filter was fabricated by application of the Deep X-ray lithography. To form the cross-linked capillary, it was operated twice exposures. In these exposures, respectively the exposure stage was tilted to difference angle. The cross-linked capillary filter fabricated in this way was applied to vertical fluid flow operation. This cross-linked capillary filter could hold and transmit the fluid by the switchover of in impressed pressure. Herewith the cross-linked micro capillary filter showed availability as high efficiency mixing device. 相似文献
7.
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9.
Takayoshi Yokoya Rikiya Yoshida Yuki Utsumi Koji Tsubota Hiroyuki Okazaki Takanori Wakita Yoshikazu Mizuguchi Yoshihiko Takano Takayuki Muro Yukako Kato Hiroshi Kumigashira Masaharu Oshima Hisatomo Harima Yoshihiro Aiura Hitoshi Sato Akihiro Ino Hirofumi Namatame Masaki Taniguchi Masaaki Hirai Yuji Muraoka 《Science and Technology of Advanced Materials》2012,13(5)
We have characterized the electronic structure of FeSe1−xTex for various x values using soft x-ray photoemission spectroscopy (SXPES), high-resolution photoemission spectroscopy (HRPES) and inverse photoemission spectroscopy (IPES). The SXPES valence band spectral shape shows that the 2 eV feature in FeSe, which was ascribed to the lower Hubbard band in previous theoretical studies, becomes less prominent with increasing x. HRPES exhibits systematic x dependence of the structure near the Fermi level (EF): its splitting near EF and filling of the pseudogap in FeSe. IPES shows two features, near EF and approximately 6 eV above EF; the former may be related to the Fe 3d states hybridized with chalcogenide p states, while the latter may consist of plane-wave-like and Se d components. In the incident electron energy dependence of IPES, the density of states near EF for FeSe and FeTe has the Fano lineshape characteristic of resonant behavior. These compounds exhibit different resonance profiles, which may reflect the differences in their electronic structures. By combining the PES and IPES data the on-site Coulomb energy was estimated at 3.5 eV for FeSe. 相似文献
10.
Mary Ann O. Torio Takafumi Itoh Roberta N. Garcia Nobuyuki Maruyama Shigeru Utsumi Evelyn Mae Tecson-Mendoza 《Food research international (Ottawa, Ont.)》2012,45(1):277-282
Sulfhydryl groups and disulfide bond were introduced in mungbean's major storage protein, 8Sα globulin, by protein engineering to improve structural stability and functional properties. Five modified proteins or mutants (F59C, I99C, A213C, one free sulfhydryl group; I99C/A213, one disulfide bridge; F59C/I99C/A213C, one free sulfhydryl group and one disulfide linkage) were expressed in Escherichia coli at a yield similar to that of the unmodified protein or wild type (WT) in soluble form (38%). The number of introduced groups in the mutants was confirmed by Ellman analysis. Mutant and WT proteins exhibited similar elution patterns on gel filtration indicating their trimeric native conformation. Mutants had 2 to 3.8 °C higher Tm values than WT and were digested by chymotrypsin at 52–58% in 60 min but exhibited different digestion patterns. All mutants showed greater hardness of heat-induced gels than WT, especially I99C/A213C and F59C/I99C/A213C. Results indicate the improved structural stability of the modified 8Sα globulin. 相似文献