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1.
A Moise R Salamon M Raissis P Nanopoulos B Clement 《Computers and biomedical research》1986,19(4):379-389
Adjustment for covariates (or poststratification) is frequently used in the analysis of randomized clinical trials. The purpose of such analysis is mainly to eliminate some residual bias resulting from any imbalance between treatment groups for some important covariates. Usually, covariate effect is modeled with the data at hand. In this paper, we present a new method of poststratification ("constrained poststratification") which consists of estimating the prognostic significance of covariates in a large historical data base, transferring the model's coefficients into the (smaller) randomized trial data set, and estimating treatment effects conditional on this a priori information. In a simulated experiment, constrained poststratification allowed not only reduction of the bias but also enhancement of the efficiency of the estimation of treatment effect. 相似文献
2.
Gault WA Brown S Moise A Liang D Sellar G Shepherd GG Wimperis J 《Applied optics》1996,35(16):2913-2922
A field-widened Michelson interferometer designed to measure upper atmospheric winds at three altitudes near the mesopause by using airglow emissions from O(1)S, OH, and O(2) is described. A very large path difference (11 cm) is used to suppress the fringes from the hot F-region emission of O(1)S and to facilitate accurate measurements. Field widening and thermal compensation are achieved over the large spectral range (557.7-866.0 nm) by the use of three types of glass in the interferometer's arms. The instrument was installed at Resolute Bay, Canada (74.3 N, 94.5 W), in November 1992 and has been operated remotely from Toronto for four winter seasons. Some examples of data are shown to illustrate ERWIN's performance. 相似文献
3.
O'Keeffe P Bolognesi P Coreno M Moise A Richter R Cautero G Stebel L Sergo R Pravica L Ovcharenko Y Avaldi L 《The Review of scientific instruments》2011,82(3):033109
A velocity map imaging/ion time-of-flight spectrometer designed specifically for pump-probe experiments combining synchrotron and laser radiations is described. The in-house built delay line detector can be used in two modes: the high spatial resolution mode and the coincidence mode. In the high spatial resolution mode a kinetic energy resolution of 6% has been achieved. The coincidence mode can be used to improve signal-to-noise ratio for the pump-probe experiments either by using a gate to count electrons only when the laser is present or by recording coincidences with the ion formed in the ionization process. 相似文献
4.
5.
The intestine is the organ that contributes the majority of circulating alimentary lipoproteins. Intestinal epithelial cells have the unique ability to elaborate chylomicrons, the largest triglyceride-rich lipoproteins and the main vehicle for the transport of dietary lipids. The final intracellular assembly and exocytosis of chylomicrons require enterocyte-derived apolipoproteins (apo). As research on lipoprotein metabolism evolved, it has become increasingly evident that apo B is a crucial protein for the normal packaging of triglyceride-rich lipoproteins. Immunocytochemical techniques have successfully been used to demonstrate the presence of two types of apo B, the B-100 and the B-48, in different subcellular compartments of the human enterocyte. Confirmation was obtained by biochemically analyzing human lymph and intestine from pediatric patients. In addition, the immunoelectron microscopic approach revealed the location of apo A-I in the rough endoplasmic reticulum (ER) and predominantly in the Golgi apparatus and the basolateral membrane, which confirms the rapid transport of apo A-I documented by other studies. Proven utility and experimental conditions were defined to demonstrate the ability of Caco-2 cells, a colon carcinoma cell line, to esterify lipids, synthesize apo, and assemble lipoproteins. Thus, immunocytochemical and biochemical techniques can be combined with in vivo and in vitro intestinal models for the study of the intestinal lipid transport. 相似文献
6.
S Riskin-Mashiah KJ Moise I Wilkins NA Ayres CD Fraser 《Canadian Metallurgical Quarterly》1998,18(12):1328-1330
We present a case of intrapericardial teratoma diagnosed by ultrasound at 26 weeks of gestation presenting as a large tumour mass and rapid development of hydrops fetalis. The fetus died in utero one day before scheduled open fetal surgery. 相似文献
7.
Rodriguez J.A. Remack K. Boku K. Udayakumar K.R. Aggarwal S. Summerfelt S.R. Celii F.G. Martin S. Hall L. Taylor K. Moise T. McAdams H. McPherson J. Bailey R. Fox G. Depner M. 《Device and Materials Reliability, IEEE Transactions on》2004,4(3):436-449
We report on the reliability properties of ferroelectric capacitors and memory arrays embedded in a 130-nm CMOS logic process with 5LM Cu/FSG. Low voltage (<1.5 V) operation is enabled by the 70-nm thick MOCVD PZT ferroelectric films. Data loss resulting from high temperature bakes is primarily caused by the imprint effect, which shows /spl sim/1.5 eV time-to-fail activation energy. Excellent bit endurance properties are observed on fully packaged memory arrays, with no degradation up to 10/sup 13/ write/read polarization switching cycles. Retention measured after 10/sup 12/ switching cycles demonstrates no degradation relative to arrays with minimal cycling. 相似文献
8.
A Di Rocco M Tagliati F Danisi D Dorfman J Moise DM Simpson 《Canadian Metallurgical Quarterly》1998,51(1):266-268
The pathogenesis of AIDS-associated vacuolar myelopathy (VM) may be related to abnormality of transmethylation mechanisms in the nervous system. To evaluate the safety and potential efficacy of the methyl-group donor L-methionine in AIDS-associated VM, we conducted a pilot clinical trial in 12 patients with VM. Seven of the nine patients who completed the study had clinical and electrophysiologic improvement. Controlled studies may be indicated to assess the efficacy and safety of L-methionine in AIDS-associated VM. 相似文献
9.
Moïse Bendayan 《Microscopy research and technique》1984,1(4):349-372
The enzyme-gold postembedding approach has been introduced recently in the field of cytochemistry for the ultrastructural localization of macromolecules. This technique is based on the affinity properties existing between an enzyme and its substrate. The possibility of detecting substrate molecules by applying enzyme-gold complexes has been established. The present review deals with the development and the technical approach of this method. Various applications are reported for the demonstration of the reliability of the technique that yields results of high specificity and resolution. In addition, some technical problems and limitations particular to this method are reported and discussed. 相似文献
10.