HIPAA's Effect on Web Site Privacy Policies

Healthcare institutions typically post their privacy practices online as privacy policy documents. We conducted a longitudinal study that examines the effects of HIPAA's enactment on a collection of privacy policy documents for a fixed set of organizations over a four-year period. We present our analysis of 24 healthcare privacy policy documents from nine healthcare Web sites, analyzed using goal mining, a content-analysis method that supports extraction of useful information about institutions' privacy practices from documents. We compare our results to our pre-HIPAA study of these same institutions' online privacy practices and evaluate their evolution in the presence of privacy laws     

Performance of in-call buffer/window allocation schemes for short intermittent file transfers over broadband packet networks

While static open loop rate controls may be adequate for handling continuous bit rate (CBR) traffic, relatively smooth data traffic, and relatively low speed bursty data traffic over broadband integrated networks, high speed bursty data sources need more dynamic controls. Burst level resource allocation is one such dynamic control. Potential benefits and other issues for burst level resource parameter negotiations for bursty data traffic over high speed wide area packet networks have been discussed earlier.^1–6 A detailed analysis of an adaptive buffer/window negotiation scheme for long file transfers using these concepts is presented in Reference 1. In this paper we discuss two burst level buffer/window negotiation schemes for short intermittent file transfers, focusing on the specific needs of such traffic streams. We develop closed network of queues models to reflect the behaviour of the proposed schemes. These models, while being simple, capture essential details of the control schemes. Under fairly general assumptions, the resulting network of queues is of product form and can be analysed using the mean value analysis. We use such an analysis to compare the proposed schemes and to determine appropriate sizes of trunk buffers to achieve the desired balance between bandwidth utilization and file transfer delay. The effects of other parameters on the performance of these schemes as well as on the buffer sizing rules are also discussed. Burst level (in-call) parameter negotiation may be carried out by the end system with the network elements or by an interface system (access controller) with the broadband network elements. We discuss implications of this location as well as the needed protocol features. Finally, the service discrimination capabilities desired at the trunk controllers in switching nodes are briefly discussed.     

Fast restoration of ATM networks

Asynchronous transfer mode (ATM) is now well recognized as the fundamental switching and multiplexing technique for future broadband ISDN. As these networks will be increasingly relied upon for providing a multitude of integrated voice, data, and video services, network reliability is a key concern. There are several intrinsic features of ATM networks that could potentially be exploited to provide improved restoration techniques, beyond those established for synchronous transfer mode (STM) networks, such as digital cross-connect restoration or self-healing rings. These features include ATM cell level error detection, inherent rate adaptation and nonhierarchical multiplexing. The authors explore the use of these features in developing fast restoration strategies for ATM networks. In particular, they address: (1) ATM error detection capabilities for enhanced failure detection, (2) network rerouting strategies, (3) spare capacity allocation, and (4) network control architecture and related implementation aspects. Their findings suggest that fast network span failure detection and bandwidth-efficient rerouting capabilities can be combined to develop restoration strategies for ATM networks with significantly greater performance-cost ratios when compared to existing STM network restoration strategies     

Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis

Cell division cycle 25A (Cdc25A) is a dual-specificity phosphatase that is overexpressed in several cancer cells and promotes tumorigenesis. In normal cells, Cdc25A expression is regulated tightly, but the changes in expression patterns in cancer cells that lead to tumorigenesis are unknown. In this study, we showed that ubiquitin-specific protease 29 (USP29) stabilized Cdc25A protein expression in cancer cell lines by protecting it from ubiquitin-mediated proteasomal degradation. The presence of USP29 effectively blocked polyubiquitination of Cdc25A and extended its half-life. CRISPR-Cas9-mediated knockdown of USP29 in HeLa cells resulted in cell cycle arrest at the G0/G1 phase. We also showed that USP29 knockdown hampered Cdc25A-mediated cell proliferation, migration, and invasion of cancer cells in vitro. Moreover, NSG nude mice transplanted with USP29-depleted cells significantly reduced the size of the tumors, whereas the reconstitution of Cdc25A in USP29-depleted cells significantly increased the tumor size. Altogether, our results implied that USP29 promoted cell cycle progression and oncogenic transformation by regulating protein turnover of Cdc25A.     

RADIAL FLOW HOLLOW FIBERREVERSE OSMOSIS: EXPERIMENTS AND THEORY

The performance of a hollow fiber reverse osmosis system is studied both theoretically and experimentally. Experiments were carried out for applied pressure ranging from 200 to 400 psig, feed rates varying from 75 to 380 cc/sec and for feed concentrations up to 34,000 ppm of sodium chloride.

A mathematical model is proposed to predict productivity, ϕ, and product concentration, θ_p. The model involves solving membrane transport equations simultaneously with the hydrodynamic equations. The solubility-diffusion-imperfection, or pore diffusion model, is used to describe solute and solvent transport across the membrane. The axial gradients of shell side concentration, neglected in previous investigations, are taken into account. The differential equations are solved numerically by the 4th Order Runge-Kutta method.

Predicted values of ϕ and θ_p agree within 8% and 17% respectively, with experimental data over the entire range of operating conditions. However, membrane transport coefficients were found to be concentration dependent.

An approximate analysis shows that the concentration polarization is negligible in present day hollow fiber systems.     

Graphical models for interactive POMDPs: representations and solutions

We develop new graphical representations for the problem of sequential decision making in partially observable multiagent environments, as formalized by interactive partially observable Markov decision processes (I-POMDPs). The graphical models called interactive influence diagrams (I-IDs) and their dynamic counterparts, interactive dynamic influence diagrams (I-DIDs), seek to explicitly model the structure that is often present in real-world problems by decomposing the situation into chance and decision variables, and the dependencies between the variables. I-DIDs generalize DIDs, which may be viewed as graphical representations of POMDPs, to multiagent settings in the same way that I-POMDPs generalize POMDPs. I-DIDs may be used to compute the policy of an agent given its belief as the agent acts and observes in a setting that is populated by other interacting agents. Using several examples, we show how I-IDs and I-DIDs may be applied and demonstrate their usefulness. We also show how the models may be solved using the standard algorithms that are applicable to DIDs. Solving I-DIDs exactly involves knowing the solutions of possible models of the other agents. The space of models grows exponentially with the number of time steps. We present a method of solving I-DIDs approximately by limiting the number of other agents’ candidate models at each time step to a constant. We do this by clustering models that are likely to be behaviorally equivalent and selecting a representative set from the clusters. We discuss the error bound of the approximation technique and demonstrate its empirical performance.     

Antineoplastic and antioxidant potential of phycofabricated silver nanoparticles using microalgae Chlorella minutissima

This study for the first time reports on fresh water microalgae Chlorella minutissima aqueous extract (CmAe) which was utilized for the biogenic synthesis of silver nanoparticles and tested their antineoplastic potential against Liver Hepatocellular Carcinoma (HepG2) cell line. The characteristic colour change of the reaction mixture from greenish yellow to yellowish brown confirmed the synthesis of Chlorella minutissima silver nanoparticles (CmAgNPs). Microscopic analysis revealed CmAgNPs to be spherical‐shaped with particle size ranging from 10 to 30 nm. The carbohydrates and proteins distinctive peaks were observed in Fourier transform infrared spectroscopy (FTIR) spectra which suggested these biomolecules acted as reducing and capping agents. Further, the crystalline nature of CmAgNPs was confirmed by X‐ray diffraction (XRD) analysis. CmAgNPs showed maximum free radical scavenging proving it to be more potent antioxidant agent as compared to CmAe. The mortality rate of HepG2 cells treated with CmAgNPs was found to be 91.8 % at 120 μg/ml with IC₅₀ value 12.42 ± 1.096 μg/ml after 48 h whereas no effect was observed on normal Human Embryonic Kidney (HEK 293) cells. Fluorescent images of the treated HepG2 cells revealed the formation of apoptotic bodies, condensed nuclei and cell shrinkage indicating their effectiveness against the cancer cells.Inspec keywords: silver, nanoparticles, nanomedicine, microorganisms, cellular biophysics, nanofabrication, scanning electron microscopy, transmission electron microscopy, atomic force microscopy, proteins, Fourier transform infrared spectra, molecular biophysics, X‐ray chemical analysis, X‐ray diffraction, kidney, cancer, biomedical materialsOther keywords: antineoplastic potential, antioxidant potential, phycofabricated silver nanoparticle, Chlorella minutissima, freshwater microalgae, aqueous extract, liver hepatocellular carcinoma cell line, CmAgNP synthesis, field emission scanning electron microscopy, high‐resolution transmission electron microscopy, atomic force microscopy, dynamic light scattering, carbohydrate, protein, Fourier transform infrared spectroscopy, biomolecule, energy‐dispersive X‐ray spectroscopy, elemental silver signal, CmAgNP crystalline, X‐ray diffraction analysis, antioxidant agent, HepG2 cell mortality rate, human embryonic kidney, HEK 293 cell, fluorescent image, apoptotic body formation, condensed nuclei, cell shrinkage, cancer cell, antineoplastic agent, Ag     

Oxide bound impact on hot-carrier degradation for gate electrode workfunction engineered (GEWE) silicon nanowire MOSFET

In this present work, we explore the hot carrier fidelity of gate electrode workfunction engineered silicon nanowire (GEWE-SiNW) MOSFET at 300 K using DEVEDIT-3D device editor and ATLAS device simulation software. TCAD simulation shows reduction in the hot carrier reliability of a GEWE SiNW MOSFET in terms of electron temperature, electron velocity and Hot Electron gate current for reflecting its efficacy in high power CMOS applications. Further, a comparative investigation for different values of oxide thickness and high-k has been done to analyze the performance of GEWE-SiNW MOSFET in terms of electrical parameters such as conduction band, DIBL, electric field, electron temperature, electric velocity and gate current. It has been clearly shown that with oxide thickness 0.5 nm the hot-carrier reliability and device performance improves in comparison to oxide thickness 2.5 nm. In addition, with k = 21(HfO₂) device performance in terms of hot-carrier reliability further enhanced due to increased capacitance and thus offer its effectiveness in sub-nm range analog applications.     

A password based authentication scheme for wireless multimedia systems

In this digital era, where Internet of Things (IoT) is increasing day by day, use of resource constrained devices is also increasing. Indeed, the features such as low cost, less maintenance, more adaptive to hostile environment, etc. make the wireless multimedia devices to be the best choice as the resource constrained devices. For the security, the end user device requires to establish the session key with the server before transferring the data. Mobile is one of the device having more and more usage as wireless multimedia device in recent years. In 2013, Li et al. proposed an efficient scheme for the wireless mobile communications and claimed it to be secure against various attacks. Recently, Shen et al. claimed that the scheme of Li et al. is still vulnerable to the privileged insider attack, the stolen verifier attack and finally proposed a scheme to withstand the mentioned and other attacks. However, in this paper we claim that the scheme of Shen et al. is still susceptible to the user anonymity, the session specific temporary information attack and the replay attack. In addition, Shen et al.’s scheme requires more time due to many operations. Further, we propose an efficient scheme that is secure against various known attacks and due to reduced time complexity our scheme is a preferred choice for the wireless mobile networks and hence for wireless multimedia systems.