Surface microgeometry of powder coatings in slipping friction: A Markov approach

The formation of wear-resistant powder surface coatings with slipping friction may be described by a statistical approach based on continuous Markov processes. The coordinates of the equilibrium frictional surface are shown to be normally distributed. The correlation of the parameters of surface wear is investigated.     

Interferon-β Activity Is Affected by S100B Protein

Interferon-β (IFN-β) is a pleiotropic cytokine secreted in response to various pathological conditions and is clinically used for therapy of multiple sclerosis. Its application for treatment of cancer, infections and pulmonary diseases is limited by incomplete understanding of regulatory mechanisms of its functioning. Recently, we reported that IFN-β activity is affected by interactions with S100A1, S100A4, S100A6, and S100P proteins, which are members of the S100 protein family of multifunctional Ca²⁺-binding proteins possessing cytokine-like activities (Int J Mol Sci. 2020;21(24):9473). Here we show that IFN-β interacts with one more representative of the S100 protein family, the S100B protein, involved in numerous oncological and neurological diseases. The use of chemical crosslinking, intrinsic fluorescence, and surface plasmon resonance spectroscopy revealed IFN-β binding to Ca²⁺-loaded dimeric and monomeric forms of the S100B protein. Calcium depletion blocks the S100B–IFN-β interaction. S100B monomerization increases its affinity to IFN-β by 2.7 orders of magnitude (equilibrium dissociation constant of the complex reaches 47 pM). Crystal violet assay demonstrated that combined application of IFN-β and S100B (5–25 nM) eliminates their inhibitory effects on MCF-7 cell viability. Bioinformatics analysis showed that the direct modulation of IFN-β activity by the S100B protein described here could be relevant to progression of multiple oncological and neurological diseases.     

Influence of absorption on nonlinear vibrations of gas in a closed pipe

We consider dissipative mechanisms involved in resonance vibrations of gas in a closed pipe. Using analysis of a resonance curve as an example, we show the existence of four regimes differing in the mechanism of dissipation. We determine their boundaries, as well as lay a foundation for the procedures used to calculate the amplitude of vibrations within these intervals. Comparison of calculating formulas with experiments conducted by various authors is made.     

Exhaust-line performance in a gas-pumping system

A promising means of determining exhaust-line performance in a gas-pumping system is to analyze the passage of the sound wave formed by the action of dynamic loads at the channel wall; the dynamic loads are due to pressure fluctuation in the gas flux.     

Mathematical modeling of heat and mass transfer processes in geocryological forecasts

A condition is found for the selection of a mathematical model of the temperature process and results are presented for the solution of the combined heat- and mass-transfer problem.Translated from Inzhenerno-Fizicheskii Zhurnal, Vol. 53, No. 1, pp. 124–129, July, 1987.     

Structure and Mechanical Properties of Al–Mg Alloy Workpieces in Multilayer Surfacing with Interlayer Deformation

Russian Engineering Research - Al–Mg alloy samples are produced by multilayer surfacing according to various strategies, with and without interlayer deformation. The samples undergo tensile...     

Mathematical simulation of radionuclide migration in freezing-thawing soils

Mathematical models of the migration of radionuclides taking account of a phase transition of the interstitial solution in soil are proposed. The moisture-transport equation can be represented in moisture and potential forms. The results of a long-time comparative numerical experiment checking the effectiveness of the proposed models using special methods of numerical simulation are presented.Translated from Atomnaya Énergiya, Vol. 97, No. 5, pp. 374–380, November, 2004.