Pre‐natal and post‐natal exposure to pet ownership and lung function in children: The Seven Northeastern Cities Study

To evaluate the association between pre‐natal and post‐natal exposure to pet ownership and lung function in children, a cross‐sectional study named Seven Northeastern Cities (SNEC) study was conducted. In this study, children's lung function including the forced expiratory volume in 1 second (FEV₁), forced vital capacity (FVC), maximal mid‐expiratory flow (MMEF), and peak expiratory flow (PEF) were measured by spirometers, and pet ownership situations were collected by questionnaire. Analyzed by multiple logistic regression and generalized linear modeling, we found that for all subjects, pet exposure in the first 2 years of life was significantly associated with lung function impairment of FVC<85% predicted (adjusted odds ratio [aOR]=1.28; 95% confidence interval [CI]: 1.01, 1.63). For current pet exposure, the increased odds of lung function impairment ranged from 35% (aOR=1.35; 95%CI: 1.12, 1.62) for FVC<85% predicted to 57% (aOR=1.57; 95%CI: 1.29, 1.93) for FEV₁<85% predicted. The in utero exposure was not related to lung function impairment. Compared with other pets, higher odds were observed among children with dogs. When stratified by gender, girls with current pet exposure were more likely to have lung function impairment than boys. It implies self‐reported exposures to pets were negatively associated with lung function among the children under study.     

Void reactivity coefficient benchmark results for a 10 × 10 BWR assembly in the full 0–100% void fraction range

A boiling water reactor SVEA-96+ fresh fuel lattice has been used as the basis for a benchmark study of the void reactivity coefficient at assembly level in the full voidage range. Results have been obtained using the deterministic codes CASMO-4, HELIOS, PHOENIX, BOXER and the probabilistic code MCNP4C, combined for almost all cases with different cross section libraries. A statistical analysis of the results obtained showed that the void reactivity coefficient tends to become less negative beyond 80% void and that the discrepancies between codes tend to increase from less than 15% at voidages lower than 40% to more than 25% at voidages higher than 70%. The void reactivity coefficient results and the corresponding differences between codes were isotopically decomposed to interpret discrepancies. The isotopic decomposition shows that the minimum observed in the void reactivity coefficient between 80% and 90% void is largely due to the decrease in the relative importance of the ¹⁵⁷Gd(n, γ) rate with increasing voidage, and that the fundamental discrepancies between codes or libraries are mainly governed by the different predictions of the ²³⁸U(n, γ) variation with voidage.     

Materials for double patterning strategies: Development and application

Double patterning has become the most promising approach to overcome the 32 nm node challenges. Several schemes have been proposed to simplify the process, each requiring very specific materials that still have to be developed and optimized. The resist platform presented here is an image lock material which has been developed to meet the Litho-Litho-Etch (or 2P1E) approach. In this paper, we present the material development of dedicated polymers for the double imaging technique. The lithographic properties of these materials are evaluated, in term of process window (PW) and Line Edge Roughness (LER). Successful patterning of 50 and 45 nm lines at 90 nm pitch has been obtained.     

Simplified Model and Closed-Loop Control of a Commutatorless DC Motor

A simplified dynamic model of a current-fed, self-commutated synchronous motor, operating with a constant angle between the motor counter electromotive force (CEMF) and the input current. The model, which is justified experimentally, includes only two time constants, associated with the rotor inertia and the dc link inductance. This permits the design of the current and speed controlling loops along the same principles used for classical armature-controlled dc motor drives. In this way, the experience which is widely available in industry can be applied, at least with a good approximation, to design of the commutatorless dc motor drives. Various control configurations are discussed. Control loops are designed and closed around the basic motor-inverter block. An experimental result is obtained for each control configuration, thus validating the proposed model.     

Experimental validation of control rod related perturbations of moderator regions in an SCWR-like fuel lattice

Two different types of perturbations of an SCWR-like fuel lattice have been investigated experimentally in the central test zone of the PROTEUS zero-power research reactor at the Paul Scherrer Institute in Switzerland. In each case, a campaign of high-resolution gamma-ray spectroscopy measurements was carried out on 34 fuel pins of the test lattice. In the first case, the test lattice was perturbed by inserting aluminum rods into the four central moderator regions, while in the second case, the perturbation was affected using steel absorber rods (instead of aluminum). The derived reaction rates are the capture rate in ²³⁸U (C₈) and the total fission rate (F_tot), as also the reaction rate ratio C₈/F_tot. Each of these has been mapped on the lattice and compared to calculated results from whole-reactor Monte Carlo simulations with MCNPX. Excellent agreement has been obtained, for both perturbed lattices, between the calculated and experimental distributions of C₈, F_tot and C₈/F_tot. Considering that control rods in an SCWR assembly are foreseen to be inserted into the central moderator regions, these results may be considered as generic validation of Monte Carlo simulations for the two different types of lattice perturbations which inserted control rods imply, viz. moderator displacement and strong neutron absorption.In a second step, calculated C₈, F_tot and C₈/F_tot distributions for the two perturbed lattices (as well as for the unperturbed lattice) have been compared, at assembly level, between MCNPX and the deterministic LWR lattice code CASMO-4E. In the case of the unperturbed lattice, as well as for the lattice with steel rods, the agreement between the codes is found to be within ～1% for all pins and each reaction rate. However, for the lattice with aluminum rods, i.e. the case with mainly just moderator displacement involved, CASMO overestimates the reaction rates in the vicinity of the perturbations by up to 2–3%, when employing the standard input options. The reason for this discrepancy has been found to be the leakage treatment, which uses the fundamental-mode buckling applied in a homogenized sense across the lattice. In this way, global leakage gradients get averaged out over the entire assembly. The optional input card BZ2 for CASMO resolves this problem, and the codes then agree within 1% even for the aluminum case.     

White paper report from working groups attending the international conference on research and educational opportunities in bio-fuel crop production

A conference on current research and educational programs in production of crops for bio-fuel was sponsored and organized by the EARTH University and the University of Florida in November, 2008. The meeting addressed current research on crops for bio-fuel production with discussions of research alternatives for future crop production systems, land use issues, ethics of food vs. fuel production, and carbon sequestration in environmentally sensitive tropical and sub-tropical regions of the Americas. The need and potential for development of graduate and undergraduate curricula and inter-institutional cooperation among educational institutions in the region were also discussed. Delegations from Belize, Brazil, Columbia, Costa Rica, Cuba, Honduras, Panama, The Dominican Republic, and the United States including ministers of Agriculture and Energy attended this meeting. Over a two-day period, four working groups provided a framework to facilitate networking, motivate task oriented creative thinking, and maintain a timely accomplishment of assigned duties in the context of the conference themes. Participants in the conference were assigned to one of four working groups, each following given topics: Agronomy, Environment, Socio-Economics and Education/Extension. It was the consensus of representatives of industry, academic and regulatory community assembled in Costa Rica that significant research, education and socio-economic information is needed to make production of bio-fuel crops sustainable. Agronomic research should include better crop selection based on local conditions, improved production techniques, pest and disease management, and mechanical cultivation and harvesting. Another conclusion was that tailoring of production systems to local soil characteristics and use of bio-fuel by-products to improve nutrient use efficiency and reduction of environmental impact on water quantity and quality is critical to sustainability of bio-fuel crop production.     

Carbon/PbO2 asymmetric electrochemical capacitor based on methanesulfonic acid electrolyte

A new hybrid electrochemical capacitor based on an activated carbon negative electrode, lead dioxide thin film and nanowire array positive electrode with an electrolyte made of a lead salt dissolved in methanesulfonic acid was investigated. It is shown that the maximum energy density and specific capacity of the C/PbO₂ nanowire system increase during the first 50 cycles before reaching their maximum values, which are 29 Wh kg⁻¹ and 34 F g⁻¹, respectively, at a current density of 10 mA cm⁻² and a depth of discharge (positive active electrode material) of 3.8%, that corresponds to a 22C rate. This is 7–8 times higher than the corresponding maximum values reached with a C/PbO₂ thin film cell operated in the same conditions. After an initial activation period, the performances of the C/PbO₂ nanowire system stay constant and do not show any sign of degradation during more than 5000 cycles. For comparison, the C/PbO₂ thin film system exhibits a 50% decrease of its performances in similar conditions.     

Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

Hepatocellular carcinoma (HCC) is the major primary malignant tumor in the human liver, but the molecular changes leading to liver cell transformation remain largely unknown. The Wnt-beta-catenin pathway is activated in colon cancers and some melanoma cell lines, but has not yet been investigated in HCC. We have examined the status of the beta-catenin gene in different transgenic mouse lines of HCC obtained with the oncogenes c-myc or H-ras. Fifty percent of the hepatic tumors in these transgenic mice had activating somatic mutations within the beta-catenin gene similar to those found in colon cancers and melanomas. These alterations in the beta-catenin gene (point mutations or deletions) lead to a disregulation of the signaling function of beta-catenin and thus to carcinogenesis. We then analyzed human HCCs and found similar mutations in eight of 31 (26%) human liver tumors tested and in HepG2 and HuH6 hepatoma cells. The mutations led to the accumulation of beta-catenin in the nucleus. Thus alterations in the beta-catenin gene frequently are selected for during liver tumorigenesis and suggest that disregulation of the Wnt-beta-catenin pathway is a major event in the development of HCC in humans and mice.