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排序方式: 共有106条查询结果,搜索用时 15 毫秒
1.
Lili Chen Nanami Fujisawa Masato Takanohashi Mazaya Najmina Koichiro Uto Mitsuhiro Ebara 《International journal of molecular sciences》2021,22(5)
This study demonstrates the rational fabrication of a magnetic composite nanofiber mesh that can achieve mutual synergy of hyperthermia, chemotherapy, and thermo-molecularly targeted therapy for highly potent therapeutic effects. The nanofiber is composed of biodegradable poly(ε-caprolactone) with doxorubicin, magnetic nanoparticles, and 17-allylamino-17-demethoxygeldanamycin. The nanofiber exhibits distinct hyperthermia, owing to the presence of magnetic nanoparticles upon exposure of the mesh to an alternating magnetic field, which causes heat-induced cell killing as well as enhanced chemotherapeutic efficiency of doxorubicin. The effectiveness of hyperthermia is further enhanced through the inhibition of heat shock protein activity after hyperthermia by releasing the inhibitor 17-allylamino-17-demethoxygeldanamycin. These findings represent a smart nanofiber system for potent cancer therapy and may provide a new approach for the development of localized medication delivery. 相似文献
2.
M Furuta K Hayakawa S Katano Y Saito Y Nakayama T Takahashi R Imai T Ebara N Mitsuhashi H Niibe 《Canadian Metallurgical Quarterly》1996,26(2):95-98
Vaccination with peptides that induce a specific immune response is a potential prophylactic or therapeutic strategy against viral infections and tumors. Because of the extensive polymorphism of the HLA loci, synthetic peptide vaccines must consist of a cocktail of peptides that bind specifically to different HLA molecules. Such cocktails should be optimized for the target population as each population has its specific HLA gene frequencies. To achieve maximum population coverage with a minimum number of peptides, information is needed on the ranking of the most frequent HLA phenotypes. We introduce the minimal phenotype panel, which is the smallest combination of HLA antigens selected so that the proportion of individuals in a population that express at least one of the antigens in the panel exceeds a desired minimum value. We developed a method for assembling minimal phenotype panels based on known HLA class I gene frequencies. We give an example based on a set of 2446 well-defined HLA-typed, random, healthy, unrelated, Dutch Caucasoid individuals. In addition, we discuss the possibility of assembling minimal phenotype panels based on two-locus haplotypes, which enables the assembly of phenotype panels from the antigens of both loci. 相似文献
3.
Fukuda H. Ebara M. Kobayashi A. Sugiura N. Yoshikawa M. Saisho H. Kondo F. Yoshino S. Yahagi T. 《IEEE transactions on bio-medical engineering》1998,45(3):396-400
To objectively evaluate the parenchymal echo pattern of cirrhotic liver and chronic hepatitis, the authors applied an image analyzing system (IAS) using a neural network. Autopsy specimens in a water tank (n=13) were used to examine the relationship between the diameter of the regenerative nodule and the coarse score (CS) calculated by IAS. CS was significantly correlated with the diameter of the regenerative nodule (p<0.0001, r=0.966). CS is considered to be useful for evaluating the coarseness of the parenchymal echo pattern 相似文献
4.
This paper aims to assess quantitatively the actual visual environment of uncontrolled urban downtown intersections in Japan in relation to frequently occurring crossing collisions and to discuss the safety countermeasures for them. In Field Study 1 dealing with direct visibility, our ultra-wide-angle photograph analysis revealed that most of the right/left-ward visible range at 11 intersections were insufficient to check safety, and the quality of direct visibility was closely associated with causing crossing collisions. The countermeasures to reduce a blind area were determined to be a top priority. In Field Study 2 dealing with indirect visibility, more than half of the 25 traffic convex mirrors had marked shortcomings for preventive safety, and ergonomics guidelines ensuring indirect visibility were proposed for installing traffic convex mirrors. Low-cost/low-technology-oriented countermeasures are highly recommended to obtain clear/sufficient images of crucial information satisfying drivers' requirements on traffic convex mirrors in accordance with those ergonomics guidelines was highly recommended. Crossing collisions could be prevented by improvement of poor direct and indirect visibility. 相似文献
5.
NS Shachter T Ebara R Ramakrishnan G Steiner JL Breslow HN Ginsberg JD Smith 《Canadian Metallurgical Quarterly》1996,98(3):846-855
We have generated transgenic mice over-expressing human apolipoprotein CI (apo CI) using the native gene joined to the downstream 154-bp liver-specific enhancer that we defined for apo E. Human apo CI (HuCI)-transgenic mice showed elevation of plasma triglycerides (mg/dl) compared to controls in both the fasted (211 +/- 81 vs 123 +/- 52, P = 0.0001) and fed (265 +/- 105 vs 146 +/- 68, P < 0.0001) states. Unlike the human apo CII (HuCII)- and apo CIII (HuCIII)-transgenic mouse models of hypertriglyceridemia, plasma cholesterol was disproportionately elevated (95 +/- 23 vs 73 +/- 23, P = 0.002, fasted and 90 +/- 24 vs 61 +/- 14, P < 0.0001, fed). Lipoprotein fractionation showed increased VLDL and IDL + LDL with an increased cholesterol/triglyceride ratio (0.114 vs 0.065, P = 0.02, in VLDL). The VLDL apo E/apo B ratio was decreased 3.4-fold (P = 0.05) and apo CII and apo CIII decreased in proportion to apo E. Triglyceride and apo B production rates were normal, but clearance rates of VLDL triglycerides and postlipolysis lipoprotein "remnants" were significantly slowed. Plasma apo B was significantly elevated. Unlike HuCII- and HuCIII-transgenic mice, VLDL from HuCI transgenic mice bound heparin-Sepharose, a model for cell-surface glycosaminoglycans, normally. In summary, apo CI overexpression is associated with decreased particulate uptake of apo B-containing lipoproteins, leading to increased levels of several potentially atherogenic species, including cholesterol-enriched VLDL, IDL, and LDL. 相似文献
6.
Takafumi Arai Ryuichiro Tanaka Katsuhisa Sakaguchi Shinjiro Umezu 《Artificial Life and Robotics》2017,22(2):197-202
Biotechnology has drastically been advanced by the development of iPS and ES cells, which are representative forms induced pluripotent stem cells. In the micro/nano bio field, the development of cells and Taylor-made medicine for a potential treatment of incurable diseases has been a center of attention. The melting point of gelatin is between 25 and 33 °C, and the sol–gel transition occurs in low temperature. This makes the deformation of this useful biomaterial easy. The examples of gelatin fiber applications are suture threads, blood vessel prosthesis, cell-growth-based materials, filter materials, and many others. Because the cell size differs depending on the species and applications, it is essential to fabricate gelatin fibers of different diameters. In this paper, we have developed a fabrication method for gelatin fibers the coacervation method. We fabricated narrow gelatin fibers having a diameter over 10 μm. 相似文献
7.
S. Lakshminarayanan G. Emoto S. Ebara K. Tomida Sirish L. Shah 《Journal of Process Control》2001,11(5):1434
The results of a joint university–industry collaborative project for control loop reconfiguration using closed loop experimental data from a fuel gas pressure control system are described in this paper. The fuel gas pressure was being regulated using a butane stream. For economic reasons, it was necessary to switch control to the ethane stream. Previous attempts at effecting this changeover had proved unsuccessful. In this study, a powerful system identification technique namely Canonical Variate Analysis (CVA) was employed to obtain the empirical plant models. A PI controller was then designed using the direct synthesis method. Acceptable closed loop behavior was obtained with little online tuning. 相似文献
8.
Yasuo Ebara 《Artificial Life and Robotics》2013,17(3-4):483-487
In remote collaborative work via WAN, sharing and recognizing various high-quality visual contents such as photography, visualization image, and real video streaming is extremely important. Supporting a high-quality display of these contents on a large-scale display system is necessary to support intellectual remote collaborative work. However, these contents are currently magnified in low resolution on a general projector used as large-sized display equipment, and these equipments are difficult to display the contents with sufficient quality. In this paper, we have focused on the tiled display wall technology which configure a wide-area screen with two or more LCD and tried to display realistic high-resolution visual contents to solve these issues. We have constructed a tele-immersive environment with a tiled display wall, and have studied the availability for intuitive remote collaborative work by implementing various collaborative applications for the effective display of high-resolution contents as well as developing interaction techniques for enormous visual contents in this environment. As a result, we have showed that the practical use of a tiled display wall is useful in the construction of intellectual remote collaborative environment. 相似文献
9.
Production of eicosapentaenoic acid by a recombinant marine cyanobacterium, Synechococcus sp. 总被引:1,自引:0,他引:1
The eicosapentaenoic acid (EPA) synthesis gene cluster from an EPA-producing bacterium, Shewanella sp. SCRC-2738, was cloned into a broad-host range vector, pJRD215, and then introduced into a marine cyanobacterium, Synechococcus sp. NKBG15041c, by conjugation. The transconjugant cyanobacteria produced 3.7±0.2% (2.24±0.13 mg/L) EPA (n-3) and 2.5 ±0.2%
(1.49±0.06 mg/L) eicosatetraenoic acid (n-3) of the total fatty acids when the cells were cultured at 23°C at a light intensity
of 1,000–1,500 Lux. The EPA and eico-satetraenoic acid contents of the cells were increased to 4.6±0.6% (3.86±1.11 mg/L) and
4.7±0.3% (3.86±0.82 mg/L), and 7.5±0.3% (1.76±0.10 mg/L) and 5.1±0.2% (1.19±0.06 mg/L) when they were cultured at low temperature
(18°C) and at lower light intensity (40 Lux), respectively. 相似文献
10.
Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties 总被引:3,自引:0,他引:3
A novel vitamin E derivative, (6″-hydroxy-2″,5″,7″,8″-tetramethylchroman-2″-yl) methyl 3-(2′,4′-dihydroxyphenyl)propionate
(TM4R), which has a chromanoxyl ring and 4-substituted resorcinol moieties, was synthesized; and its inhibitory effects on
tyrosinase, antioxidant ability, and lightening effect of ultraviolet B (UVB)-induced hyperpigmentation were estimated. TM4R
showed potent inhibitory activity on tyrosinase, which is the rate-limiting enzyme in melanogenesis. The scavenging activities
of TM4R on 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals were found to be nearly the same as those of α-tocopherol.
Furthermore, an efficient lightening effect was observed following topical application of TM4R to UVB-stimulated hyperpigmented
dorsal skin of brownish guinea pigs. These results suggest that TM4R may be a candidate for an efficient whitening agent,
possibly by inhibiting tyrosinase activity and biological reactions caused by reactive oxygen species. 相似文献