Visceral Obesity and Its Shared Role in Cancer and Cardiovascular Disease: A Scoping Review of the Pathophysiology and Pharmacological Treatments

The association between obesity, cancer and cardiovascular disease (CVD) has been demonstrated in animal and epidemiological studies. However, the specific role of visceral obesity on cancer and CVD remains unclear. Visceral adipose tissue (VAT) is a complex and metabolically active tissue, that can produce different adipokines and hormones, responsible for endocrine-metabolic comorbidities. This review explores the potential mechanisms related to VAT that may also be involved in cancer and CVD. In addition, we discuss the shared pharmacological treatments which may reduce the risk of both diseases. This review highlights that chronic inflammation, molecular aspects, metabolic syndrome, secretion of hormones and adiponectin associated to VAT may have synergistic effects and should be further studied in relation to cancer and CVD. Reductions in abdominal and visceral adiposity improve insulin sensitivity, lipid profile and cytokines, which consequently reduce the risk of CVD and some cancers. Several medications have shown to reduce visceral and/or subcutaneous fat. Further research is needed to investigate the pathophysiological mechanisms by which visceral obesity may cause both cancer and CVD. The role of visceral fat in cancer and CVD is an important area to advance. Public health policies to increase public awareness about VAT’s role and ways to manage or prevent it are needed.     

Child Death From Pediatric Illness: Conceptualizing Intervention From a Family/Systems and Public Health Perspective.

Despite the universal and understandable distress associated with the death of a child from pediatric illness, do psychologists help surviving families in ways that match their need for assistance? Many families do not seek psychological help and cope adaptively with their loss. Indications for psychotherapy with bereaved families are based largely on experience with families who engage in treatment and who have greater distress. Other families may not receive sufficient services but are at risk for ongoing difficulties and unlikely to engage in treatment. Suggestions for intervention are made, with attention to the fit of therapeutic approaches with family needs. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A prospective investigation of the impact of childhood sexual abuse on the development of sexuality.

The sexual attitudes and activities of 77 sexually abused and 89 comparison women (mean age=20.41, SD=3.38) were assessed 10 years after disclosure in a longitudinal, prospective study of the long-term effects of childhood sexual abuse. Abused participants were more preoccupied with sex, younger at first voluntary intercourse, more likely to have been teen mothers, and endorsed lower birth control efficacy than comparison participants. When psychological functioning earlier in development was examined, sexual preoccupation was predicted by anxiety, sexual aversion was predicted by childhood sexual behavior problems, and sexual ambivalence (simultaneous sexual preoccupation and sexual aversion) was predicted by pathological dissociation. Findings also indicate that biological father abuse may be associated with greater sexual aversion and sexual ambivalence. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Acceptability of genetically modified cheese presented as real product alternative

European consumers, in general, have negative attitudes towards the use of gene technology in food production. The objective of this study was to examine whether taste and health benefits influence the acceptability of genetically modified (gm) products when they are presented as real product alternatives. Consumers in Denmark, Finland, Norway and Sweden (n=738) assessed two cheeses: one was labelled as genetically modified (preferred in an earlier product test) and the other as conventional (neutral in an earlier product test). A smaller control group received two cheeses with blind codes. Labelling decreased consumers' intentions to buy the originally preferred gm-labelled cheese, but still the intentions were at the same level with the conventionally labelled option. Participants chose two gm cheeses out of five possible when given the option to take cheese home after tasting. Intentions to buy gm cheese could best be explained by respondents' attitudes towards gene technology and perceived taste benefits. General health interest was also a reinforcer of intentions for gm cheese with reduced fat content.     

Visualizing transport structures of time-dependent flow fields

This article focuses on the transport characteristics of physical properties in fluids-in particular, visualizing the finite-time transport structure of property advection. Applied to a well-chosen set of property fields, the proposed approach yields structures giving insights into the underlying flow's dynamic processes.     

Fiber-optic transmission of stretched pulses from a Q-switched ruby laser

Fiber-optic transmission of Q-switched ruby laser pulses is limited by fiber damage owing to the high laser-beam intensities. Pulse stretching with a semiconductor-based control circuit for the Pockels cell of the ruby laser to reduce the peak intensities is described. Pulses with durations from 200 ns to 1 μs and a coherence length of ~3 m were generated. These pulses were coupled into multimode optical fibers to investigate the transmission characteristics and the limits of transmittable pulse energies. Stretched pulses can be transmitted in quartz fibers with a 600-μm core diameter to pulse energies of 300 mJ, which is an increase by a factor of 4 compared with standard Q-switched pulses. It is expected that beam guiding of ruby laser pulses by fiber optics will significantly facilitate the use of holographic interferometry in technical applications such as vibration analysis.     

Topology‐based Smoothing of 2D Scalar Fields with C1‐Continuity

Data sets coming from simulations or sampling of real‐world phenomena often contain noise that hinders their processing and analysis. Automatic filtering and denoising can be challenging: when the nature of the noise is unknown, it is difficult to distinguish between noise and actual data features; in addition, the filtering process itself may introduce “artificial” features into the data set that were not originally present. In this paper, we propose a smoothing method for 2D scalar fields that gives the user explicit control over the data features. We define features as critical points of the given scalar function, and the topological structure they induce (i.e., the Morse‐Smale complex). Feature significance is rated according to topological persistence. Our method allows filtering out spurious features that arise due to noise by means of topological simplification, providing the user with a simple interface that defines the significance threshold, coupled with immediate visual feedback of the remaining data features. In contrast to previous work, our smoothing method guarantees a C¹‐continuous output scalar field with the exact specified features and topological structures.     

Smooth Shape‐Aware Functions with Controlled Extrema

Functions that optimize Laplacian‐based energies have become popular in geometry processing, e.g. for shape deformation, smoothing, multiscale kernel construction and interpolation. Minimizers of Dirichlet energies, or solutions of Laplace equations, are harmonic functions that enjoy the maximum principle, ensuring no spurious local extrema in the interior of the solved domain occur. However, these functions are only C⁰ at the constrained points, which often causes smoothness problems. For this reason, many applications optimize higher‐order Laplacian energies such as biharmonic or triharmonic. Their minimizers exhibit increasing orders of continuity but lose the maximum principle and show oscillations. In this work, we identify characteristic artifacts caused by spurious local extrema, and provide a framework for minimizing quadratic energies on manifolds while constraining the solution to obey the maximum principle in the solved region. Our framework allows the user to specify locations and values of desired local maxima and minima, while preventing any other local extrema. We demonstrate our method on the smoothness energies corresponding to popular polyharmonic functions and show its usefulness for fast handle‐based shape deformation, controllable color diffusion, and topologically‐constrained data smoothing.