Glibenclamide for the Treatment of Ischemic and Hemorrhagic Stroke

Ischemic and hemorrhagic strokes are associated with severe functional disability and high mortality. Except for recombinant tissue plasminogen activator, therapies targeting the underlying pathophysiology of central nervous system (CNS) ischemia and hemorrhage are strikingly lacking. Sur1-regulated channels play essential roles in necrotic cell death and cerebral edema following ischemic insults, and in neuroinflammation after hemorrhagic injuries. Inhibiting endothelial, neuronal, astrocytic and oligodendroglial sulfonylurea receptor 1–transient receptor potential melastatin 4 (Sur1–Trpm4) channels and, in some cases, microglial K_ATP (Sur1–Kir6.2) channels, with glibenclamide is protective in a variety of contexts. Robust preclinical studies have shown that glibenclamide and other sulfonylurea agents reduce infarct volumes, edema and hemorrhagic conversion, and improve outcomes in rodent models of ischemic stroke. Retrospective studies suggest that diabetic patients on sulfonylurea drugs at stroke presentation fare better if they continue on drug. Additional laboratory investigations have implicated Sur1 in the pathophysiology of hemorrhagic CNS insults. In clinically relevant models of subarachnoid hemorrhage, glibenclamide reduces adverse neuroinflammatory and behavioral outcomes. Here, we provide an overview of the preclinical studies of glibenclamide therapy for CNS ischemia and hemorrhage, discuss the available data from clinical investigations, and conclude with promising preclinical results that suggest glibenclamide may be an effective therapeutic option for ischemic and hemorrhagic stroke.     

A color image watermarking framework for copyright protection of stereo images based on binocular just noticeable difference and LU decomposition

Multimedia Tools and Applications - The copyright protection of three-dimensional (3D) content is a matter of interest in artistic and creative works due to the rights of the holder for the...     

Active time scheduling for rechargeable sensor networks

Recent progress in energy harvesting technologies made it possible to build sensor networks with rechargeable nodes which target an indefinitely long operation. In these networks, the goal of energy management is to allocate the available energy such that the important performance metrics, such as the number of detected threats, are maximized. As the harvested energy is not sufficient for continuous operation, the scheduling of the active and inactive time is one of the main components of energy management. The active time scheduling protocols need to maintain the energy equilibrium of the nodes, while considering the uncertainties of the energy income, which is strongly influenced by the weather, and the energy expenditures, which are dependent on the behavior of the targets. In this paper, we describe and experimentally compare three active time scheduling protocols: (a) static active time, (b) dynamic active time based on a multi-parameter heuristic and (c) utility-based uniform sensing. We show that protocols which take into consideration the probabilistic models of the energy income and expenditure and can dynamically adapt to changes in the environment, can provide a significant performance advantage.     

Real-time 2D–3D filtering using order statistics based algorithms

The paper presents a review of the author’s own results obtained in the last several years. Some examples of real-time processing of 2D and 3D images are described. In particular, we discuss the noise model and objective criteria that can be applied to characterize the performance of the processing algorithms. Several proposed algorithms based on RM approach are compared with other known ones, demonstrating the advantages in noise suppressing and preservation of fine image details and edges. A number of 2D and 3D image denoising filters are implemented on DSP, realizing real-time mode in the image processing. The performances of the proposed processing algorithms and the known ones are discussed and evaluated here.

Rheological studies with spherically shaped thin liquid films

The present work shows the first experimental and theoretical results for investigations on the rheology of liquid films. The experiments are planned to be performed under microgravity conditions. This environment will allow forming films of different thickness, which is impossible under ground conditions due to drainage. Then the films are forced to harmonic oscillations of the film area so that the film elasticity can be measured as a function of frequency. The presented theoretical model demonstrates the main relationships to be solved under corresponding boundary conditions     

卤化物钙钛矿射线探测器材料研究进展

卤化物钙钛矿由于具有高射线吸收系数、高载流子迁移率寿命乘积、可低温溶液法生长等特性,有望突破传统高纯锗和碲锌镉探测器在成本、芯片兼容性和大尺寸成像等方面的制约,成为新一代性能优异的室温射线探测材料。本文从卤化物钙钛矿材料的基本性质与射线探测原理出发,介绍了2015年以来卤化物钙钛矿射线探测材料与器件的发展历程;系统介绍了直接型射线探测器(强度、成像、能谱)及闪烁体探测器的最新研究成果;分析了材料特性与器件结构对射线探测器性能的影响机制,为今后更高效的卤化物钙钛矿射线探测器的开发提供参考。     

The perceived risk of the Line 5 Pipeline and spills under ice

Using the psychometric paradigm of risk in conjunction with surveys of the Michigan public (n = 638) and a regional planning organization (n = 65), we examine the perceived risk and concerns associated with underwater oil pipelines, the Enbridge Line 5 pipeline in particular, and oil spills under ice. The fate of Line 5 is heavily debated in Michigan, specifically the portion that traverses the Straits of Mackinac, which can be ice-covered for months. Scant literature examines how individuals perceive the risk associated with Line 5, its alternatives, or potential spills in open water or under ice. Here we identify considerable concern regarding both the pipeline and the potential for spills under ice on behalf of the public, and increased concern about spills under ice on behalf of the planning organization. Organization members' concerns are significantly predicted by beliefs about the difficulty in remediating spills, however not by beliefs about spills' likelihood, difficulty in detection, noticeability, or consequences. Our results identify the need to better examine and communicate the risks associated with underwater pipelines and spills, both in open water and under ice, as well as options for remediating oil captured under ice. Furthermore, we recommend the adoption of decision-making and risk governance processes that explicitly expand analysis of the social, economic and environmental tradeoffs of underwater pipelines such as Line 5.     

Guidelines and recommendations for indoor use of fuel cells and hydrogen systems

Hydrogen energy applications often require that systems are used indoors (e.g., industrial trucks for materials handling in a warehouse facility, fuel cells located in a room, or hydrogen stored and distributed from a gas cabinet). It may also be necessary or desirable to locate some hydrogen system components/equipment inside indoor or outdoor enclosures for security or safety reasons, to isolate them from the end-user and the public, or from weather conditions.Using of hydrogen in confined environments requires detailed assessments of hazards and associated risks, including potential risk prevention and mitigation features. The release of hydrogen can potentially lead to the accumulation of hydrogen and the formation of a flammable hydrogen-air mixture, or can result in jet-fires. Within Hyindoor European Project, carried out for the EU Fuel Cells and Hydrogen Joint Undertaking safety design guidelines and engineering tools have been developed to prevent and mitigate hazardous consequences of hydrogen release in confined environments. Three main areas are considered: Hydrogen release conditions and accumulation, vented deflagrations, jet fires and including under-ventilated flame regimes (e.g., extinguishment or oscillating flames and steady burns). Potential RCS recommendations are also identified.