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1.
CM Tsai SH Hsiao CM Frey KT Chang RP Perng AF Gazdar BS Kramer 《Canadian Metallurgical Quarterly》1993,53(5):1079-1084
Both cisplatin (CDDP) and leucovorin (LV) have been shown to enhance cytotoxicity of 5-fluorouracil (FUra) against murine and human neoplasms by increasing intracellular reduced folate concentrations. We were interested in their use in a combination to inhibit non-small cell lung cancer (NSCLC) cell growth and therefore conducted an in vitro study to investigate the cytotoxic activities of combinations of CDDP plus FUra, with and without LV (20 microM), against seven NSCLC cell lines. A tetrazolium assay with application of the classical isobole method was used to test drug combinations. We found that LV enhanced FUra but not CDDP cytotoxicity and that the degree of enhancement was negatively correlated with the effect of FUra. There was an overall additive combination effect of CDDP plus FUra, although there may be synergy at higher effect levels. There was synergy to a combination of CDDP, FUra, and LV, presumably primarily related to the synergistic effects of adding LV to FUra. In summary, LV and CDDP enhanced FUra cytotoxicity in a complementary fashion and there was clear synergy of a combination of CDDP, FUra, and LV against a panel of NSCLC cell lines. Our in vitro results provide a rationale for controlled clinical studies of this three-drug regimen in patients with NSCLC. 相似文献
2.
Based on some useful frequency domain methods, this paper proposes a systematic procedure to address the limit cycle prediction
of a neural vehicle control system with adjustable parameters. A simple neurocontroller can be linearized by using describing
function method firstly. According to the classical method of parameter plane, the stability of linearized system with adjustable
parameters is then considered. In addition, gain margin and phase margin for limit cycle generation are also analyzed by adding
a gain-phase margin tester into open loop system. Computer simulations show the efficiency of this approach. 相似文献
3.
Jau-Woei Perng 《Neural computing & applications》2012,21(3):555-563
In this paper, some useful frequency domain methods including describing function, parameter space, and Kharitonov approach
are applied to analyze the stability of an uncertain fuzzy vehicle control system for limit cycle prediction. A systematic
procedure is proposed to solve this problem. The fuzzy controller can be linearized by the use of classical describing function
firstly. By doing so, it is feasible to treat the stability problem of a fuzzy control system as linear one. In order to consider
the robustness of a fuzzy vehicle control system, parameter space method and Kharitonov approach are then employed for plotting
the stability boundaries. Furthermore, the effect of transport delay is also addressed. More information of limit cycles can
be obtained by this approach. This work shows that the limit cycles caused by a static fuzzy controller can be easily suppressed
if the system parameters are chosen carefully. 相似文献
4.
The exact positional and total orientation workspaces of a hexapod parallel mechanism are three-dimensional volumes that are too complicated for an operator to make use of, but a knowledge of them is indispensable in order to avoid collisions with the environment and to locate the workpiece. Fortunately, the positional and total orientation workspaces of a symmetric simplified architecture (the SSM type) can be bounded from inside and outside by ellipsoids symmetric about the z-axis. Accordingly, this paper presents closed-form solutions for the radii of the inscribed and circumscribed circles of the positional workspace and approximate solutions for the total orientation workspace at any given height. These solutions can be plotted on a two-dimensional graph that is convenient for an operator on the shop floor. Furthermore, these solutions can be developed into a simple procedure for the design of a prescribed workspace. 相似文献
5.
A robust system for backlit keyboard inspection is revealed. The backlit keyboard not only has changeable diverse colors but also has the laser marking keys. The keys on the keyboard can be divided into regions of function keys, normal keys, and number keys. However, there might have some types of defects:incorrect illuminating area, non-uniform illumination of specified inspection region (IR), and incorrect luminance and intensity of individual key. Since the illumination features of backlit keyboard are too complex to inspect for human inspector in the production line, an auto-mated inspection system for the backlit keyboard is proposed in this paper. The system was designed into the operation module and inspection module. A set of image processing methods were developed for these defects inspection. Some experimental results demonstrate the robustness and effectiveness of the proposed system. 相似文献
6.
Tzu-Kang Chin Ming-Wei Liao Tsong-Pyng Perng 《Journal of the American Ceramic Society》2022,105(10):6041-6048
A polysulfone (PSF) hollow fiber composed of interconnected nanofibers within its wall was employed as a template to deposit with a layer of TiO2 by atomic layer deposition. Direct nitridation of the TiO2-coated PSF hollow fiber at 800 and 1000°C was conducted, and a new hierarchical structure of TiOxN1−x and TiN@nitrogen-doped carbon hollow fibers, respectively, was formed. The PSF fiber served as the source of carbon and was directly transformed to a nitrogen-doped carbon fiber because the shape change was confined by the TiO2 coating. In the meantime, TiOxN1−x or TiN was formed after the nitridation of TiO2. X-ray photoelectron spectrometric analysis indicated that there was no chemical bonding between the nitridized coating and the carbon nanofibers. It implies that the nitridation of TiO2 and carbonization of PSF proceed independently and simultaneously in the nitridation process. Raman spectroscopic analysis also confirmed the formation of graphitic lattice and Ti–N bonding. Electrical measurement indicated that both fibers were highly conductive, with the electrical resistivity in the order of 10−5 Ω m, which is lower than those of amorphous carbon and graphite along the direction perpendicular to the basal plane. 相似文献
7.
Yi-Ning Chao David Sun Yen-Chun Peng Yuh-Lin Wu 《International journal of molecular sciences》2016,17(8)
Cyclooxygenase-2 (COX-2) and interleukin-8 (IL-8) are two important inflammatory mediators in ovulation. Ghrelin may modulate inflammatory signaling via growth hormone secretagogue receptors. We investigated the role of ghrelin in KGN human ovarian granulosa cells using protein kinase C (PKC) activator phorbol 12, 13-didecanoate (PDD) and synthetic ghrelin analog growth hormone releasing peptide-2 (GHRP-2). GHRP-2 attenuated PDD-induced expression of protein and mRNA, the promoter activity of COX-2 and IL-8 genes, and the secretion of prostaglandin E2 (PGE2) and IL-8. GHRP-2 promoted the degradation of PDD-induced COX-2 and IL-8 proteins with the involvement of proteasomal and lysosomal pathways. PDD-mediated COX-2 production acts via the p38, c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathways; PDD-mediated IL-8 production acts via the p38, JNK and ERK pathways. GHRP-2 reduced the PDD-induced phosphorylation of p38 and JNK and activator protein 1 (AP-1) reporter activation and PDD-induced NF-κB nuclear translocation and reporter activation. The inhibitors of mitogen-activated protein kinase phosphatase-1 (MKP-1) and protein phosphatase 2 (PP2A) reduced the inhibitory effect of GHRP-2 on PDD-induced COX-2 and IL-8 expression. Our findings demonstrate an anti-inflammatory role for ghrelin (GHRP-2) in PKC-mediated inflammation of granulosa cells, at least in part, due to its inhibitory effect on PKC-induced activation of p38, JNK and NF-κB, possibly by targeting to MKP-1 and PP2A. 相似文献
8.
A numerical analysis is made of the unsteady flow and heat transfer characteristics of mixed convection in a vertical block-heated channel with and without installing an inclined plate above an upstream block. Parameter studies including the inclined plate angle, Reynolds number (ranging from 260 to 530), and Grashof number (in the range of 0-3,200,000) on heat transfer performance have been explored in detail. The results show that the installation of an inclined plate in the vertical block-heated channel can effectively augment the blocks' heat transfer performance in the channel. 相似文献
9.
Yeng-Horng Perng Yi-Kai Juan Sheng-Fen Chien 《Canadian Metallurgical Quarterly》2006,132(10):1037-1042
Most open tendering procedures in the real world are highly complex, uncertain, and costly. With an increasing emphasis on the quality and value of procurement, economically most advantageous tender (EMAT) has been widely adopted as an alternative contract-awarding criteria, which has changed competitive strategies in the construction industry. A conceptual model of competitive bidding in EMAT is first established to reflect the credibility of the bidding situation. A bidding game for EMAT projects is performed by 24 participants to partially test the conceptual model. The result reveals that the game has the potential to reveal important factors in the bidding situation, simulate competitive bidding behaviors, and explore competitive advantages in the EMAT bidding process. The learning effect from the game should be useful for contractors who are preparing to deliver optimal tenders in EMAT projects. 相似文献
10.
To conform with the requirements of the international Government Procurement Agreement and the regulations of the World Trade Organization, the Taiwan Government Procurement Law (GPL) was enacted in 1999. The main points of the agreement and barriers affecting price competition are illustrated. Award prices for subcentral government civil engineering projects are compared before and after the law went into effect. The result suggests that civil engineering prices have decreased significantly since the introduction of the law, that the transparent and open-tendering system enforced by the law has led to an increase in competition, and that tender prices decreased during the initial period. During the same period, construction companies' average rate of profit on sales moved from positive to negative. It is concluded that severe bidding competition is expected after Taiwan completes accession to the agreement. 相似文献