The evaluation on the effect of shell thickness reduction for ITER vacuum vessel sector 1 and 6

The structural analyses of vacuum vessel have been performed to investigate the effect of shell thickness reduction on structural integrity. The finite element models of vacuum vessel considering original design and thickness reduction have been developed. The expected maximum thickness reduction possibly caused by forming and bending processes during fabrication was applied to the curved region of the analysis models. The linear elastic and nonlinear limit analyses have been performed. The structural integrity of main vessel including lower port stub extension has been verified in accordance with the requirements of RCC-MR. It is concluded that the inner and outer shells of main vessel still have enough strength margins under pressure and VDE (Vertical Displacement Event) load conditions in spite of thickness reduction. These results have been reviewed and approved by ITER Organization and ANB (Agreed Notified Body).     

Design assessment for manufacturability of supporting structures for IWS and ELM coil of ITER vacuum vessel

A vacuum vessel is one of the core facilities of ITER (International Thermonuclear Experimental Reactor) and basically all-welded structure. Korea is responsible for the procurement of sector 1 and 6 of the main vessel. Accordingly, the design review for the fabrication is in progress by ITER Korea and Hyundai Heavy Industries. Due to anticipated manufacturing problems such as the welding distortion, the design of some components of main vessel, IWS (In-Wall Shield) supporting rib and ELM (Edge Localized Mode) coil support, needs to be modified. To release the risk of welding distortion, the welding method called “bridge type” is suggested and the shape of weld joint is adjusted to secure the manufacturability of the issued components. The elastic and limit analyses with fatigue evaluation have been performed under the most critical loading condition to verify the structural integrity of modified design. Analysis results show that the proposed designs meet the design criteria of RCC-MR. The design deviation requests have been submitted to ITER Organization and ANB (Agreed Notified Body) for approval and their verification is currently in progress.     

Engineering investigation for the size effect of graphene oxide derived from graphene nanoplatelets in polyurethane composites

In this study, commercial polyurethane (PU) and graphene nanoplatelets (GnP) and their derivative graphene oxide (GO) were used to fabricate PU composites. The size effect of fillers on mechanical properties and anti-corrosion performance of as-prepared composites was thoroughly investigated. It was found that GO was more uniformly dispersed in the PU matrix than GnP due to its compatibility with PU. Furthermore, GO led to the higher mechanical properties and anti-corrosion performance than PU/GnP composites, and the properties were strongly dependant on the size of the GO. Specifically, incorporating large sized GO (GO-M25) in 0.5 wt% indicated the highest average synergetic tensile modulus up to 53% from the neat PU and the lowest corrosion rate of 0.001 MPY (1 MPY = 0.547 g · m⁻² · d⁻¹). This phenomenon was attributed to the fact that the larger size of GO is not only uniformly dispersed within the PU matrix but also enables interaction between PU and GO. Conversely, PU composites incorporated with the small sized GO (GO-C750) did not show elastic behaviour from 0.1 to 0.5 wt% of the filler. This is due to the fact that the high surface area and hydrophilic functionalities of GO-C750 resulted in hard-segment content reduction in PU. This research can help in the design of a PU coating that is physically improved and that has a superior anti-corrosive capacity, particularly for pipelines in the oil-sands transportation industry.     

Experimental analysis of the effect of metal thickness on the quality factor in integrated spiral inductors for RF ICs

The effect of metal thickness on the quality (Q-) factor of the integrated spiral inductor is investigated in this paper. The inductors with metal thicknesses of 5/spl sim/22.5 /spl mu/m were fabricated on the standard silicon substrate of 1/spl sim/30 /spl Omega//spl middot/cm in resistivity by using thick-metal surface micromachining technology. The fabricated inductors were measured at GHz ranges to extract their major parameters (Q-factor, inductance, and resistance). From the experimental analysis assisted by FEM simulation, we first reported that the metal thickness' effect on the Q-factor strongly depends on the innermost turn diameter of the spiral inductor, so that it is possible to improve Q-factors further by increasing the metal thickness beyond 10 /spl mu/m.     

Organic-aqueous crossover coating process for the desmopressin orally disintegrating microparticles

The purpose of the present study was to prepare desmopressin orally disintegrating microparticles (ODMs) using organic-aqueous crossover coating process which featured an organic sub-coating followed by an aqueous active coating. Sucrose beads and hydroxypropyl cellulose (HPC) were used as inert cores and a coating material, respectively. Characterizations including size distribution analysis, in-vitro release studies and in-vitro disintegration studies were performed. A pharmacokinetic study of the ODMs was also conducted in eight beagle dogs. It was found that sucrose beads should be coated using organic solvents to preserve their original morphology. For the active coating, the aqueous coating solution should be used for drug stability. When sucrose beads were coated using organic-aqueous crossover coating process, double-layer ODMs with round shapes were produced with detectable impurities below limit of US Pharmacopeia. The median size of ODMs was 195.6?μm, which was considered small enough for a good mouthfeel. The ODMs dissolved in artificial saliva within 15?s because of hydrophilic materials including sucrose and HPC in the ODMs. Because of its fast-dissolving properties, 100% release of the drug was reached within 5?min. Pharmacokinetic parameters including C_max and AUC₂₄ indicated bioequivalence of the ODMs and the conventional immediate release tablets. Therefore, by using the organic-aqueous crossover coating process, double-layer ODMs were successively prepared with small size, round shapes and good drug stability.     

Preparation and in vivo evaluation of spray dried matrix type controlled-release microparticles of tamsulosin hydrochloride for orally disintegrating tablet

The objective of this study was to achieve an optimal formulation of spray dried matrix type controlled-release (MTCR) microparticles containing tamsulosin hydrochloride for orally disintegrating tablet. To control the release rate of tamsulosin hydrochloride, Acrylate-methacrylate copolymer (Eudragit(?) L-100 or Eudragit(?) S-100) and ethylcellulose were employed on the composition of MTCR microparticles. Physicochemical properties of MTCR microparticles such as particle size and SEM were characterized. Pharmacokinetic parameters of tamsulosin hydrochloride were evaluated in the rats after oral administration. MTCR microparticles were spherical microparticles of around 10 μm diameter with a corrugated surface. ODTs containing MTCR microparticles were disintegrated within 30 s and MTCR microparticles were able to control the release rate of tamsulosin hydrochloride following Fickian diffusion mechanism. The in vitro release rates of tamsulosin hydrochloride from MTCR microparticles were proportional to the ratio of Acrylate-methacrylate copolymer to ethylcellulose. Moreover, MTCR microparticles retarded the in vivo release rate of tamsulosin hydrochloride without reducing the bioavailability. Our results suggest that MTCR microparticles may be potential oral dosage forms to control the release and to improve the bioavailability of tamsulosin hydrochloride.     

A Comparative Study Between Spray-Drying and Fluidized Bed Coating Processes for the Preparation of Pramipexole Controlled-Release Microparticles for Orally Disintegrating Tablets

In the present study, controlled-release microparticles for orally disintegrating tablets (ODT) were prepared using two different processes, spray drying and fluidized bed coating processes. Pramipexole dihydrochloride monohydrate (PRM), an anti-Parkinson's disease agent, was selected as a model drug. The in vitro release rate and morphology of microparticles were evaluated and compared. The size of microparticles prepared by spray drying (SD microparticles) and fluidized bed coating (FC microparticles) was around 10 and 200 µm, respectively. The latter size was defined by the size of an inert core bead. The release behavior of SD microparticles was characterized by a large initial burst release prior to slow release. In the case of FC microparticles, the initial burst release was smaller than that of SD microparticles and the compression process damaged the release-controlling layer, which led to a change in release rate. The results indicated the importance of carefully considering the manufacturing process for microparticles during the design of controlled-release ODT.     

CMOS-compatible surface-micromachined suspended-spiral inductors for multi-GHz silicon RF ICs

Fully CMOS-compatible, highly suspended spiral inductors have been designed and fabricated on standard silicon substrates (1/spl sim/30 /spl Omega//spl middot/cm in resistivity) by surface micromachining technology (no substrate etch involved). The RF characteristics of the fabricated inductors have been measured and their equivalent circuit parameters have been extracted using a conventional lumped-element model. We have achieved a high peak Q-factor of 70 at 6 GHz with inductance of 1.38 nH (at 1 GHz) and a self-resonant frequency of over 20 GHz. To the best of our knowledge, this is the highest Q-factor ever reported on standard silicon substrates. This work has demonstrated that the proposed microelectromechanical systems (MEMS) inductors can be a viable technology option to meet the today's strong demands on high-Q on-chip inductors for multi-GHz silicon RF ICs.     

Walking pattern generation employing DAE integration method

A stable walking pattern generation method for a biped robot is presented in this paper In general, the ZMP (zero moment point) equations, which are expressed as differential equations, are solved to obtain a stable walking pattern However, the number of differential equations is less than that of unknown coordinates in the ZMP equations It is impossible to integrate the ZMP equations directly since one or more constraint equations are involved in the ZMP equations To overcome this difficulty, DAE (differential and algebraic equation) solution method is employed The proposed method has enough flexibility for various kinematic structures Walking simulation for a virtual biped robot is performed to demonstrate the effectiveness and validity of the proposed method The method can be applied to the biped robot for stable walking pattern generation     

Effects of Adhesives and Permeation Enhancers on the Skin Permeation of Captopril

To formulate a transdermal drug delivery system of captopril, monolithic adhesive matrix type patches containing 20% captopril, different pressure-sensitive adhesives, and various permeation enhancers were prepared using a labcoater. The effects of the adhesives and permeation enhancers on skin permeation of captopril from the prepared patches were evaluated using Franz diffusion cells fitted with excised rat skins. The permeation rate of the drug through the excised skin was dependent on the type of polyacrylate copolymers studied. Fatty alcohols resulted in a pronounced enhancing effect on the skin permeation of captopril, while dimethyl sulfoxide,N-methyl-2-pyrrolidone, oleic acid, Transcutol, and polysorbate 20 showed no significant enhancing effect. The permeation-enhancing effect of the fatty alcohols reached the maximum at the level of 10%. Based on these results, a captopril patch may be developed with further optimization.