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Gadolinium induced apoptosis of human embryo liver L02 cell line by ROS-mediated AIF pathway 总被引:1,自引:0,他引:1
Gd3+ complexes have a variety of medical applications.In order to shed light on the mechanism of hepatotoxicity of Gd3+ compounds,we investigated the effects of GdCl3 on human embryo liver cell strand (L02 cells).The experimental results showed that long-time exposure to GdCl3 resulted in L02 cell apoptosis.The incubation of L02 cells with GdCl3 first induced increase in cellular reactive oxygen species (ROS) and decrease in mitochondrial inner membrane potential (?ψm).It later resulted in the activation of poly (ADP-ribose) polymerase (PARP) and the release of mitochondrial apoptosis-inducing factor (AIF).The activation of caspase 3,however,was not observed.Antioxidants could significantly reduce GdCl3-induced decrease of Δψm,release of AIF,and cell apoptosis.Although GdCl3 caused a significant increase in cell membrane permeability in L02,the change of cell membrane permeability was unlikely to be involved in GdCl3-induced cell apoptosis.Overall,our experimental results suggested that GdCl3 induced apoptosis of human embryo liver L02 cell line by ROS-mediated AIF pathway. 相似文献
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主要阐述了锅炉运行中氧腐蚀的机理及其影响因素;介绍了当今国内外水脱氧常用方法的原理、研究进展,并对各种方法的优缺点进行了分析.其中超重力脱氧是一种比较新的技术,原理简单,操作方便,投资小,效率高,发展前景好. 相似文献
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