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1.
Abstract

Recently, a literature has emerged using empirical techniques to study the evolution of international cities over many centuries; however, few studies examine long-run change within cities. Conventional models and concepts are not always appropriate and data issues make long-run neighbourhood analysis particularly problematic. This paper addresses some of these points. First, it discusses why the analysis of long-run urban change is important for modern urban policy and considers the most important concepts. Second, it constructs a novel data set at the micro level, which allows consistent comparisons of London neighbourhoods in 1881 and 2001. Third, the paper models some of the key factors that affected long-run change, including the role of housing. There is evidence that the relative social positions of local urban areas persist over time but, nevertheless, at fine spatial scales, local areas still exhibit change, arising from aggregate population dynamics, from advances in technology, and also from the effects of shocks, such as wars. In general, where small areas are considered, long-run changes are likely to be greater, because individuals are more mobile over short than long distances. Finally, the paper considers the implications for policy.  相似文献   
2.
Rats given medial frontal lesions on Postnatal Day 1 or Day 10 were trained on the Morris water task on Days 19–21 or Days 56–58. The operated groups were equally impaired at the water task on Days 19–21, but the Day 10 rats had recovered by 56 days. Dendritic arborization and spine density were analyzed in parietal layer II–III pyramidal cells. At Day 60, but not at Day 22, the Day 10 animals had more dendritic spines per unit dendritic length than did the controls or Day 1 rats. Thus, there was functional recovery rather than sparing after frontal lesions at 10 days, and the recovery was correlated with an increase in dendritic spines. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
3.
Due to the unique requirements of a series of projects to specify communications architectures using graphical representations (Cara and MFD), we have developed the communications-oriented rule-based language Carla (Cara Rule Language), which provides an executable specification of the architecture being developed. Carla is designed to provide the ability to specify and simulate high-level, possibly incomplete, specifications of communications architectures, and to allow the developer to refine the specification through the addition of behavior-describing rules. Carla is also well-suited to creating black-box specifications of any system whose behavior depends on input/output history. We describe the features of the language, discuss various design issues, and provide examples of various communications protocols specified in Carla.  相似文献   
4.
The present study describes the development of an enzyme-linked immunosorbent assay capable of quantifying serum antibody of all four canine IgG subclasses. A panel of subclass-restricted and subclass-specific monoclonal antibodies was used to measure IgG subclasses in the serum of healthy dogs, as well as in dogs with a range of clinical diseases. The subclasses have been redefined as IgG1, IgG2, IgG3 and IgG4 based on a comparison with the relative concentration and electrophoretic mobilities of human IgG subclasses. In serum samples from healthy dogs, the concentration of IgG1 (mean, 8.17 +/- 0.95 mg ml-1) and IgG2 (mean, 8.15 +/- 3.16 mg ml-1) were very similar and considerably higher than the levels of IgG3 (mean, 0.36 +/- 0.43 mg ml-1) and IgG4 (mean, 0.95 +/- 0.45 mg ml-1). There was no apparent difference in the level of subclasses between the different breeds comprising this normal population. Sera from dogs with a range of immune-mediated or inflammatory diseases all had markedly elevated levels of IgG2 (more than 13 mg ml-1), but IgG1 decreased (less than 4 mg ml-1) to levels below the normal range.  相似文献   
5.
We show the massive reduction achievable, in both emissions and climate change impact, from enhanced nuclear energy use on the forecasts of future world energy use and its associated environmental impacts. A range encompassing the major scenarios for the World's energy demand have been analyzed using the latest version of the climate-modeling MAGICC/SCENGEN software (Version 4.1). We have updated and predicted the impacts of 80% substitution with CO2-free sources (likely predominantly nuclear) for coal-fired electricity (by 2030) and for transportation fuel (by 2040). For transportation, hydrogen produced by CO2-free sources would replace gasoline and diesel fuels. In this paper, to bracket the range of futures, we simply focus on two scenarios from the Intergovernmental Panel on Climate Change's (IPCC), one (A1FI) that is energy-profligate and one (B2) that is energy-conserving.The results show that, interestingly, projected average global temperatures for all scenarios are fairly similar until about 2035 (a further rise beyond the 1990 average temperature of +0.75 ± 0.1 K) regardless of energy usage and its sources. However, by 2050, the different IPCC scenarios diverge markedly. Understandably, A1FI is projected to have noticeably stronger effects than B2 on average global temperatures (about 0.3 K more in 2050) but the effect is much stronger over land at mid and high latitudes (up to almost 1 K more). What is most striking is that the substitution of CO2-free sources gives projected average temperature rises in 2050 over key land areas (North America and China) that are very similar for the two energy-use scenarios—typically 1–1.5 K because A1FI's additional energy is predominantly supplied by nuclear. In contrast, projected rises with the unaltered cases are markedly different being about 2.5 K for A1FI and 1.5–2 K for B2. The projected changes in rainfall distribution show similar patterns, especially for the expected increases in higher latitudes.With the assumption of no additional policies for substitution of energy sources beyond 2040, temperature divergence between the two scenarios of relative energy profligacy or conservation grows in the latter half of the 21st century, even with substitution. However, the early substitution of nuclear energy and hydrogen appears to buy time and is not crucially dependent on severe, near-term curtailment of energy use. Near-term curtailment is too difficult to implement at a time of rapid industrialization of major emerging economies. Of course, proportionately larger deployments of CO2-free energy sources are needed for more energy-intensive scenarios.Nuclear power must dominate as the source of CO2-free energy since it is proven, dependable, available on a large scale, and economic. Social objections to nuclear energy in some countries and quarters are seen as well-meaning but misguided distractions from solving the energy and environmental crises that are now facing world sustainability. The time for real technical, social and political action is now.  相似文献   
6.
This paper discusses the need for interface management within construction, with particular reference to building facade interfaces. It categorizes the three different types of interface management—physical, contractual, and organizational. The implication of interface management in construction contracting is discussed; it is explained how the U.K. procurement trends have changed, affecting the interface management within projects. U.K. cladding procurement is very fragmented, and the paper maps the development of a typical cladding system showing the complexities of interface management. Finally, the paper discusses CladdISS, a U.K. government funded research project to develop a standardized strategy for the design and management of window and cladding interfaces. It explains the principles of CladdISS with reference to process maps, action plans, management strategy, bibliography, advice on standards, materials, maintenance, joints, movement, and tolerances. This will enable strategies to be developed to avoid the endemic interface problems occurring on-site. It will also guide the management of the interfaces throughout the project.  相似文献   
7.
A specific radioimmunoassay for platelet-activating factor (PAF) sensitive in the range 10–1000 pg (0.02–2 pmoles) has been developed. Detailed quantitative hapten inhibition studies showed specificity for the acetyl group at C-2 of PAF, a requirement for the ether linkage at C-1 and some tolerance for substituents on the choline nitrogen. No significant cross-reactivity was found with phosphatidylcholine and lysophosphatidylcholine or with lysoPAF. Based on a paper presented at the Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl Ether Lipids, Tokyo, Japan, May 1989.  相似文献   
8.
INTRODUCTION: Phacoemulsification and falls are both common in the elderly population. We present a case of acquired total aniridia and vitreous haemorrhage occurring as a result of trauma in a pseudophakic eye. METHODS: Interventional case report with history, clinical photograph and discussion with literature review. RESULTS: A previously healthy 74-year-old Caucasian female was referred with a painful left eye and poor vision following a fall and trauma to the left side of her face. Initial examination confirmed visual acuity of perception of light with total hyphaema and vitreous haemorrhage. Subsequent examination revealed complete aniridia with an intact capsular bag and well-centred posterior chamber intraocular lens and attached retina. Final visual acuity after treatment was 6/9. CONCLUSIONS: Blunt trauma may cause total iris disinsertion in and expulsion from pseudophakic eyes. This relatively novel injury may present increasingly commonly to casualty departments and ophthalmologists.  相似文献   
9.
Using optimal control techniques we derive and demonstrate the use of an explicit single-step control method for directing a nonlinear system to a target orbit and keeping it there. We require that control values remain near the uncontrolled settings. The full nonlinearity of the problem in state space variables is retained. The “one-step” of the control is typically a composition of known or learned maps over (a) the time required to learn the state, (b) the time to compute the control and (c) the time to apply the control. No special targeting is required, yet the time to control is quite rapid. Working with the dynamics of a well-studied nonlinear electrical circuit, we show how this method works efficiently and accurately in two situations: when the known circuit equations are used, and when control is performed only on a Poincaré section of the reconstructed phase space. In each case, because the control rule is known analytically, the control strategy is computationally efficient while retaining high accuracy. The target locations on the selected target trajectory at each control stage are determined dynamically by the initial conditions and the system dynamics, and the target trajectory is an approximation to an unstable periodic orbit of the uncontrolled system. A linear stability analysis shows that dissipation in the dynamical system is essential for reaching a controllable state.  相似文献   
10.
Temporal message-flow diagrams (TMFDs), alternatively called sequence charts, interaction diagrams, event traces, or actor diagrams, are illustrations of a system's global message-passing activity over time, and a pictorial aid to understanding the system's behavior. They are widely used for requirements and documentation for network protocols and object-oriented applications. We present a general formalism for TMFDs, describe a suite of tools we have designed that employs this formalism, and present our experiences with these tools. The formalism and tools described serve to support and broaden the use of TMFDs in developing communicating systems.  相似文献   
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