Characterization,in vitro bioactivity and biological studies of sol-gel-derived TiO2 substituted 58S bioactive glass

Bioactive glasses (BGs) have been used for bone formation and bone repair processes in recent years. This study investigated the titanium substitution effect on 58S BGs (Ti-BGs) 60SiO₂-(36 − X)CaO-4P₂O₅-XTiO₂ (X = 0, 3, and 5 mol.%) prepared by the sol-gel technique, and the main goal was to find the optimum amount of titanium in Ti-BGs. Synthesized BGs, which were investigated after immersion in simulated body fluid (SBF), were tested by X-ray diffraction (XRD) analysis, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy. Moreover alkaline phosphate (ALP) activity, 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and antibacterial studies were employed to investigate the biological properties of Ti-BGs. According to the FTIR and XRD test results, hydroxyapatite (HA) formation on Ti-BGs surfaces was confirmed. Meanwhile, the presence of 5 mol.% compared to 3 mol.% increased the HA grain distribution and their size on the Ti-BGs surface. Additionally, MTT and ALP results confirmed that the optimal amount of titanium substitution in BG was 5 mol.%. Since 5 mol.% Ti incorporated BG (BG-5) had the highest biocompatibility level, antibacterial properties, maximum cell proliferation, and ALP activity among the synthesized Ti-BGs, it is presented as the best candidate for further in vivo investigations.     

Cognitive Radio Transmission Based on Direct Sequence MC-CDMA

In this paper, we propose a cognitive cellular system based on DS MC-CDMA to coexist with a number of narrow-band legacy systems in the same frequency range. If the bandwidth and the frequency location of each narrow-band system are known to this cognitive MC-CDMA, it is possible to mitigate their interfering effect in the cognitive receivers by adaptive transmission. We will develop an algorithm for calculating the adaptive transmission parameters and show that it combats interference in the channel effectively.     

Optimal motion planning for parallel robots via convex optimization and receding horizon

In this paper, the problem of motion planning for parallel robots in the presence of static and dynamic obstacles has been investigated. The proposed algorithm can be regarded as a synergy of convex optimization with discrete optimization and receding horizon. This algorithm has several advantages, including absence of trapping in local optimums and a high computational speed. This problem has been fully analyzed for two three-DOF parallel robots, ie 3s-RPR parallel mechanism and the so-called Tripteron, while the shortest path is selected as the objective function. It should be noted that the first case study is a parallel mechanism with complex singularity loci expression from a convex optimization problem standpoint, while the second case is a parallel manipulator for which each limb has two links, an issue which increases the complexity of the optimization problem. Since some of the constraints are non-convex, two approaches are introduced in order to convexify them: (1) A McCormick-based relaxation merged with a branch-and-prune algorithm to prevent it from becoming too loose and (2) a first-order approximation which linearizes the non-convex quadratic constraints. The computational time for the approaches presented in this paper is considerably low, which will pave the way for online applications.     

A participative end-user method for multi-perspective business process elicitation and improvement

A business process can be characterized by multiple perspectives (intentional, organizational, operational, functional, interactional, informational, etc). Business process modeling must allow different stakeholders to analyze and represent process models according to these different perspectives. This representation is traditionally built using classical data acquisition methods together with a process representation language such as BPMN or UML. These techniques and specialized languages can easily become hard, complex and time consuming. In this paper, we propose ISEA, a participative end-user modeling approach that allows the stakeholders in a business process to collaborate together in a simple way to communicate and improve the business process elicitation in an accurate and understandable manner. Our approach covers the organizational perspective of business processes, exploits the information compiled during the elicitation of the organizational perspective and touches lightly an interactional perspective allowing users to create customized interface sketches to test the user interface navigability and the coherence within the processes. Thus, ISEA can be seen as a participative end-user modeling approach for business process elicitation and improvement.     

Failure analysis of unidirectional polymeric matrix composites with two serial pin loaded-holes

The objective of this study is to investigate the effects of geometrical and physical parameters on failure modes and failure loads in unidirectional polymeric matrix composites with two serial pin loaded holes, analytically and experimentally. It is assumed that all of unidirectional fibers in the laminate lie in one direction while loaded by a load p ₀ at infinity, parallel to the direction of the fibers. To derive equilibrium equations based on a Shear-Lag theory, a rectangular arrangement of fibers is considered and with the proper use of boundary and boundness conditions, stress and displacement fields are computed within the laminate, along with the surrounding pinholes. Finally by using the Hashin criterion failure modes and failure loads are estimated. To validate analytical results based on shear-lag theory, an experimental program is carried out. A very good agreement is observed between two procedures. Based on results, in small sizes of two pins, the dominant failure mode is bearing and with the increasing of hole sizes, failure modes are changed to tension and shear modes.     

Analysis of bioheat transfer equation for hyperthermia cancer treatment

Magnetic fluid hyperthermia is a new subclass of hyperthermia cancer treatment that can selectively heat up a tumor without damaging the surrounding healthy tissues. Some authors studied the temperature distribution of a magnetically mediated tumor assuming a homogeneous distribution of nanoparticles inside the tumor. Practically speaking, the injected nanoparticles do not usually distribute uniformly throughout the entire tumor, thus leaving some parts of the tumor without nanoparticles. In this study, an inhomogeneous dispersion of nanoparticles inside the tumor is assumed to investigate the tissues’ temperature profiles. The problem is solved for polar coordinate. Also in this study, the heating effect of magnetic fluid in a porcine liver tissue is experimentally examined. Numerical transient solutions are found to be in good agreement with experimental data.     

A Comprehensive Study of Market Prediction from Efficient Market Hypothesis up to Late Intelligent Market Prediction Approaches

Computational Economics - This paper has scrutinized the process of testing market efficiency, data generation process and the feasibility of market prediction with a detailed, coherent and...