Listening to parents' voices: Participatory action research in the schools.

How can schools and parents work together more effectively? This article describes a participatory action research (PAR) project with a group of parents whose children had been classified as having emotional disabilities. As the parents shared their stories of trying to navigate the special education system, they developed critical consciousness about their experiences of stress, powerlessness, and alienation. They became mobilized and obtained information about testing, diagnostic classification, and educational options for their children. Armed with this information, they developed and implemented an action plan to improve family-school relationships at the local, community, and state levels. The article concludes with an example of how the PAR model can be exported to a variety of mental health settings. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Technological development of Brazilian telecommunications in past decades

Brazilian telecommunications sector has undergone important modifications in the last 40 years. From a badly structured system of municipal level operators in 1960, with barely one million fixed lines to a large, nation-wide system with about 50 million fixed plus another 75 million mobile lines in 2005. This work paper reviews the institutional framework of telecommunications industrial and technological policy in Brazil in the last four decades, its results and present situation. Infrastructure and services modernisation and expansion process that happened in early 1970s were carried out at the expense of massive import of products and technology. A government strategy was, then, devised to stimulate local industrial and technological development in telecommunications, under the general guidelines of import substitution policy. Essential to this strategy was the creation of an innovation system around TELEBRÁS Research and Development Centre. This technological development model was successful while a protectionist economic policy existed. When economic and political circumstances could not anymore sustain an import substitution approach, in the 1990-decade, the model fell apart and has not been replaced by any other sectorial policy. A critical assessment is carried out, analysing the adopted actions in face of the digital technology maturing process that occurred in meantime.     

Laser sintering of coated polyamide 12: a new way to improve flammability

Journal of Materials Science - In this study coatings of kaolin and talc particles were successfully applied on the surface of polyamide 12 powder intended for laser sintering (LS). Microscopic...     

Using qualitative research to develop culturally competent evidence-based practice.

Kazdin (see record 2008-03389-001) pointed out that the requirement for evidence-based practice (EBP) has made the long-standing gap between research and practice in clinical psychology even more salient. He offered several strategies for bridging this gap: investigating mechanisms and moderators of therapeutic change, and qualitative research. We agree that qualitative research can be useful in bridging the gap between research and clinical practice (Silverstein & Auerbach, 2007; Silverstein, Auerbach, & Levant, 2006). In this comment we discuss using qualitative research to develop EBP that is culturally competent. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

GZ17-6.02 Inhibits the Growth of EGFRvIII+ Glioblastoma

Epidermal Growth Factor Receptor (EGFR) is amplified in over 50% of glioblastomas and promotes tumor formation and progression. However, attempts to treat glioblastoma with EGFR tyrosine kinase inhibitors have been unsuccessful thus far. The current standard of care is especially poor in patients with a constitutively active form of EGFR, EGFRvIII, which is associated with shorter survival time. This study examined the effect of GZ17-6.02, a novel anti-cancer agent undergoing phase 1 studies, on two EGFRvIII+ glioblastoma stem cells: D10-0171 and D317. In vitro analyses showed that GZ17-6.02 inhibited the growth of both D10-0171 and D317 cells with IC₅₀ values of 24.84 and 28.28 µg/mL respectively. RNA sequencing and reverse phase protein array analyses revealed that GZ17-6.02 downregulates pathways primarily related to steroid synthesis and cell cycle progression. Interestingly, G17-6.02’s mechanism of action involves the downregulation of the recently identified glioblastoma super-enhancer genes WSCD1, EVOL2, and KLHDC8A. Finally, a subcutaneous xenograft model showed that GZ17-6.02 inhibits glioblastoma growth in vivo. We conclude that GZ17-6.02 is a promising combination drug effective at inhibiting the growth of a subset of glioblastomas and our data warrants further preclinical studies utilizing xenograft models to identify patients that may respond to this drug.     

Using qualitative research to strengthen clinical practice.

Does qualitative research have the potential to be useful to practitioners? How might it improve the practice of professional psychology for clients and for practitioners? This article describes the qualitative research paradigm, discusses how it can be adapted to clinical practice, and provides an example of a qualitative study that practitioners can easily accomplish. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A review of research methods in IO/OB work-family research.

A methodological review was conducted of work-family (WF) research published in industrial-organizational psychology and organizational behavior journals over a period of 24 years (1980-2003). Content analysis was conducted on 225 individual studies published in 210 articles to categorize methodological features, including the research design, sources of data used, data analysis techniques, reliability and validity of measures used, and sociodemographic characteristics of the samples. Results support many of the criticisms of WF research and suggest that scholars publishing WF research in industrial-organizational psychology and organizational behavior journals could make greater use of longitudinal and experimental research designs, gather more multisource data, and move beyond the individual level of analysis. Adopting more diverse conceptualizations of family, including a greater proportion of racial and ethnic minorities, and studying workers in occupations other than managerial or professional positions also appear warranted. Finally, methodological trends varied across specific WF content areas, which suggests that distinct methodologies might be useful to advance knowledge of specific WF topics. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Lesions of the pedunculopontine tegmental nucleus increase sucrose consumption but do not affect discrimination or contrast effects.

Pedunculopontine tegmental nucleus (PPTg) lesions block place preferences to drugs or food only when animals are nondeprived. PPTg lesions also disrupt operant responding, but lesioned rats cannot discriminate active from inactive levers. It is not clear, therefore, whether PPTg lesions block reward or disrupt the ability to differentiate changes in reward magnitude. These hypotheses were tested by measuring sucrose consumption, choice, and contrast effects after PPTg lesions. Both sham and lesioned rats consumed greater amounts of a sucrose solution as the concentration and level of deprivation were increased. Given a choice between 2 solutions, all rats consumed more of the higher concentration. Both groups exhibited contrast effects when the concentration was shifted from 32% to 4% within a session. Somewhat surprisingly, lesions increased sucrose intake when rats were food-restricted. These results suggest that PPTg lesions do not disrupt primary motivation or the ability to evaluate and respond to changes in reward strength. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Development of particulate treatments and coatings to reduce SiC degradation by liquid aluminum

SiC-particulate-reinforced aluminum alloys are potentially attractive materials for structural applications. Among the fabrication possibilities, the molten metal mixing technique is one of the most promising in terms of cost and production capacity. Degradation of SiC by chemical reaction with molten aluminum is a problem that could be, at least partially, overcome by treatments or coatings of the reinforcements. This article describes the various techniques that have been used to coat particles and presents results ob-tained during remelting of composites. Prior oxidation of particles, oxide coating by sol-gel, or dry mixing techniques are thus presented. Oxidation of particles and TiO₂ coatings slow the degradation of SiC. Analytical electron microscopy was used to characterize the interfacial reactions that occurred during fabrication and remelting of composites. Possible mechanisms of protection are then presented and discussed.