Ordered dynamic channel assignment scheme with reassignment inhighway microcells

An ordered dynamic channel assignment with reassignment (ODCAR) scheme is proposed, and its performance is studied in a highway microcellular radio environment. Channels are assigned in an ordered basis in conjunction with a minimax algorithm under cochannel interference constraints, to provide high capacity and to alleviate worst case channel congestion in each microcell. Simulation results show significant performance improvements in terms of channel utilization and probability of call failure, at the expense of an increase in complexity and call switching requirements     

Strength degradation of sandstone and granodiorite under uniaxial cyclic loading

Change in mechanical properties of rocks under static loading has been widely studied and documented. However, the response of rocks to cyclic loads is still a much-debated topic. Fatigue is the phenomenon when rocks under cyclic loading fail at much lower strength as compared to those subjected to the monotonic loading conditions. A few selected cored granodiorite and sandstone specimens have been subjected to uniaxial cyclic compression tests to obtain the unconfined fatigue strength and life. This study seeks to examine the effects of cyclic loading conditions, loading amplitude and applied stress level on the fatigue life of sandstone, as a soft rock, and granodiorite, as a hard rock, under uniaxial compression test. One aim of this study is to determine which of the loading conditions has a stronger effect on rock fatigue response. The fatigue response of hard rocks and soft rocks is also compared. It is shown that the loading amplitude is the most important factor affecting the cyclic response of the tested rocks. The more the loading amplitude, the shorter the fatigue life, and the greater the strength degradation. The granodiorite specimens showed more strength degradation compared to the sandstone specimens when subjected to cyclic loading. It is shown that failure modes of specimens under cyclic loadings are different from those under static loadings. More local cracks were observed under cyclic loadings especially for granodiorite rock specimens.     

Nanoscale Management of CO Transport in CO2 Electroreduction: Boosting Faradaic Efficiency to Multicarbon Products via Nanostructured Tandem Electrocatalysts

Tandem catalysis presents a promising strategy to improve the selectivity toward multicarbon products in the electrocatalytic carbon dioxide reduction reaction (CO₂RR). For CO₂RR, CO is a critical intermediate for producing multicarbon products. However, the management of CO localization and CO diffusion remains underexplored despite its critical role. Herein, a 3D tandem catalyst electrode with silver nanoparticles (Ag NPs) is designed to generate CO as an intermediate product within a copper (Cu) nanoneedle array. Via this nanostructured design, CO₂ forms C²⁺ products with a high Faradaic efficiency (FEC²⁺) of 64% in an H-cell and 70% in a flow cell with a current density of 350 mA cm⁻². These figures-of-merit are currently among the top literature reports. More importantly, in situ Raman spectroscopy and finite-element method calculations are employed to elucidate the origins of enhanced selectivity. These approaches reveal the crucial role of prolonging the CO diffusion path length for improving CO utilization during CO₂ conversion with tandem catalyst systems. The favorable CO2RR FEC²⁺ in two distinct environments (H-cell and flow cell) further corroborates that this effect is not limited to a particular reactor environment. Overall, this study provides new insights for designing tandem catalysts for improved CO₂RR selectivity to C²⁺ products.     

Dynamic channel assignment with queuing in highway microcells

The effect of queuing on an ordered dynamic channel assignment with reassignment (QODCAR) scheme in a highway microcellular environment are studied. Results show that queuing improves channel use by approximately 9-43%, and significantly lowers the probability of call failure.<>     

Therapeutic Targeting of the Leukaemia Microenvironment

In recent decades, the conduct of uniform prospective clinical trials has led to improved remission rates and survival for patients with acute myeloid leukaemia and acute lymphoblastic leukaemia. However, high-risk patients continue to have inferior outcomes, where chemoresistance and relapse are common due to the survival mechanisms utilised by leukaemic cells. One such mechanism is through hijacking of the bone marrow microenvironment, where healthy haematopoietic machinery is transformed or remodelled into a hiding ground or “sanctuary” where leukaemic cells can escape chemotherapy-induced cytotoxicity. The bone marrow microenvironment, which consists of endosteal and vascular niches, can support leukaemogenesis through intercellular “crosstalk” with niche cells, including mesenchymal stem cells, endothelial cells, osteoblasts, and osteoclasts. Here, we summarise the regulatory mechanisms associated with leukaemia–bone marrow niche interaction and provide a comprehensive review of the key therapeutics that target CXCL12/CXCR4, Notch, Wnt/b-catenin, and hypoxia-related signalling pathways within the leukaemic niches and agents involved in remodelling of niche bone and vasculature. From a therapeutic perspective, targeting these cellular interactions is an exciting novel strategy for enhancing treatment efficacy, and further clinical application has significant potential to improve the outcome of patients with leukaemia.     

Characterization of a novel bioactive poly[(lactic acid)‐co‐(glycolic acid)] and collagen hybrid matrix for dermal regeneration

Different strategies have been explored for the purpose of autologous or allogeneic dermal regeneration. We have developed a hybrid matrix by lyophilizing collagen within a poly[(lactic acid)‐co‐(glycolic acid)] (10:90, molar composition) knitted mesh, in order to assimilate the advantages of natural and synthetic materials. The porosity of the mesh was found to be almost 95 %, using Micro‐Computed Tomography Analysis, while the mechanical properties were comparable to native skin. In vitro biocompatibility was analyzed by culturing rat dermal fibroblasts in the matrices over 10 days. The cells were able to attach, proliferate and remain viable within the hybrid matrices. Subsequently, in vivo biocompatibility was analyzed by implanting the matrices subcutaneously in immunocompetent rats, for 2 weeks. Histological analysis showed that the poly[(lactic acid)‐co‐(glycolic acid)]–collagen hybrid matrices evoked minimal host tissue response in vivo. This study forms the basis of using poly[(lactic acid)‐co‐(glycolic acid)]–collagen hybrid matrices for our future work to develop a bioactive matrix for dermal regeneration. Copyright © 2005 Society of Chemical Industry     

Aqueous hydrolysis of tallow for the production of glycerin: Model development and study on parametric sensitivity

Glycerin is produced by aqueous hydrolysis of tallow fat under high pressure and temperature in the absence of catalysts in a countercurrent extractor. A mathematical model describing the material and energy flows across different phases is formulated to study the degree of hydrolysis at different temperatures as well as at different feed raw material ratios. As the temperature and pressure play important roles in the degree of hydrolysis, it is necessary to understand the reaction mechanism and kinetics to find out the safer dynamics of the process. Degree of hydrolysis is found for different operating parameters under the influence of phase equilibrium. Mathematical model consisting of partial differential equation (PDE), ordinary differential equation (ODE), and algebraic equation representing mass and energy balances under both steady and transient operating conditions using first principle method are solved to find temperature profiles along the hydrolyzer which are validated using real-time data. The validation of process model using real plant data shows best fit ensuring the accuracy of process model with negligible model mismatch. Bifurcation/sensitivity analysis has been done to investigate the nature of process parameters.     

Quality changes of farmed cobia steaks held in cold stores (−18 °C)

Cobia (Rachycentron canadum) steaks held in cold store (?18 °C) were analysed aseptically in triplicates for the sensory, total aerobic bacterial count, proximate composition, pH, thiobarbituric acid‐reactive substance (TBA‐RS), formaldehyde, total volatile base nitrogen (TVB‐N), trimethyl amine‐nitrogen (TMA‐N), salt soluble nitrogen (SSN), nonprotein nitrogen (NPN), sodium dodecyl sulphate‐poly acrylamide gel electrophoresis (SDS‐PAGE) pattern. Steaks were sensorially acceptable up to 5 months of storage and the total bacterial counts did not exceed 6 log CFU counts. There were no significant changes in the pH values. TBA‐RS values increased significantly (P < 0.05) and reached 7.34 mg of malonaldehyde kg^?1 fat at the end. Formaldehyde content remained constant upto 4th month and later increased to 2.06 μg g^?1 (P < 0.05). TVB‐N and TMA‐N values did not exceed the acceptable limits. NPN contents showed no change, while SSN contents increased to 1.24% after 5 months. SDS‐PAGE pattern indicated no protein denaturation in the fish tissue. Results indicated that TBA‐RS value can only be considered as the valuable indicator in determining the quality of fish steaks held in cold stores.     

Novel cascaded H-bridge sub-multilevel inverter with reduced switches towards low total harmonic distortion for photovoltaic application

The main objective of this paper is to develop a novel inverter to produce multilevel output voltage. This paper proposes the cascaded H-bridge with sub-multilevel inverter (CHBSMLI) using three unequal DC sources in order to get 15-level output voltage. The unequal DC sources can be obtained from photovoltaic cell. The proposed CHBSMLI reduces the number of switches which in turn reduces the switching losses. The multicarrier sine Pulse Width Modulation (PWM) technique is proposed to obtain pure sinusoidal signal with reduced total harmonic distortion (THD). The performance analysis of the proposed three-phase CHBSMLI carried out using MATLAB/simulink with minimised THD and switching loss. The gating signals are generated using a Spartan-3E FPGA processor. The single-phase 15-level CHBSMLI with PWM developed to validate the simulation result.     

Physicochemical properties of the starchy flour extracted from sweet potato tubers through lactic acid fermentation

The efficiency of starch extraction from sweet potato tubers was improved by lactic acid fermentation using a mixed culture inoculum. Study of the properties of the starchy flour showed that there was a significant reduction in the starch content and consequently the soluble and apparent amylose contents of fermented samples from all six varieties used. A fall in peak viscosity and viscosity breakdown was observed for fermented samples, while the pasting temperature was enhanced significantly. The fermented flour showed greater solubility and reduced swelling. Differential scanning calorimetry studies indicated a delay in gelatinisation and a fall in enthalpy of gelatinisation of the starch on fermentation. Unlike cassava, all the properties of the starch from sweet potato tubers, ie viscosity, swelling, solubility, gelatinisation temperature, amylose content and starch content, were affected by fermentation, and variation was also observed among cultivars. Copyright © 2005 Society of Chemical Industry