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排序方式: 共有1709条查询结果,搜索用时 15 毫秒
1.
Lipid products formed during desaturation of [1-14C] stearyl CoA by hen liver microsomes 总被引:1,自引:0,他引:1
A number of lipid products are formed during the desaturation of stearyl CoA by hen liver microsomes. This article presents an analysis of the products formed when [1-14C] stearyl CoA is incubated with hen liver microsomes for various time periods. [1-14C] Oleyl CoA was the first radioactive unsaturated product formed. Synthesis of phospholipids containing [1-14C] oleic acid occurs only after the desaturase activity has begun to decline. The specific radioactivity of [1-14C] oleyl CoA was similar to the specific radioactivity of [1-14C] stearyl CoA at all time periods tested. The specific radioactivities of [1-14C] oleic acid and phospholipids containing [1-14C] oleic acid were much lower than that of the [1-14C] stearyl CoA. 相似文献
2.
The action of the tumor promoter, phorbol 12,13-dibutyrate (PDBu), on rabbit peritoneal and human neutrophils is associated
with stimulation of14C-arachidonic acid incorporation into phospholipids within 1–2 min. Stimulated14C-arachidonate incorporation was relatively selective for phosphatidylinositol (PI) in rabbit neutrophils. In contrast, the
secretory response of human neutrophils to PDBu coincided with stimulated label incorporation into phosphatidylserine (PS),
phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) and PI. Significant increases in label incorporation
were observed with PDBu concentrations as low as 2 nM, and the dose response of stimulated label incorporation paralleled
that of evoked lysozyme secretion. A parallel, but partial, inhibition of PDBu-stimulated PI labeling and enzyme release was
observed after exposing rabbit neutrophils to calcium-deprived medium, whereas calcium deprivation failed to significantly
depress either of these stimulant actions of PDBu in human neutrophils. Further, in rabbit neutrophils PDBu elicited an increase
in cell associated45Ca. However, PDBu was unable to promote the incorporation of32P orthophosphate into PI or enhance phospholipase A2 activity in broken cells. These findings suggest that one expression of the interaction between phorbol esters and their
receptors on neutrophils involves the turnover of arachidonic acid in phospholipids. This stimulated turnover of arachidonate
may be a critical step in the cascade of events associated with neutrophil activation. 相似文献
3.
Caroline Cannizzo 《Polymer》2005,46(4):1269-1276
Translucent boronic acid-carrying nanolatexes are prepared by copolymerisation of vinylbenzyl chloride in microemulsion followed by post functionalisation with 3-aminophenylboronic acid. The diol binding capacity and selectivity of the phenylboronic acid remain unchanged after anchoring to polymer nanoparticles (16 nm diameter, 0.22 mmol/g). The binding of a catechol dye, Alizarin Red S (ARS), to the boronic acid-carrying nanoparticles affords a colored, stable, nanolatex which is used for the selective visual detection of fructose in a competitive assay. The binding of fructose at pH 8.2 is readily evidenced by a color change and monitored by UV/Vis spectroscopy. The nanosensor can be regenerated in acidic medium. The entrapment of the nanolatex in a dialysis cell provides a re-usable support for binding and optical detection. 相似文献
4.
Tariq Benamara Piotr Breitkopf Ingrid Lepot Caroline Sainvitu 《Structural and Multidisciplinary Optimization》2016,54(4):843-855
This paper presents a reformulation of the “Gappy Proper Orthogonal Decomposition” (Gappy-POD) multi-fidelity modeling approach and proposes an enrichment criterion associated with an adaptive infill algorithm. The latter is here applied to the study of the flight domain of the RAE-2822 transonic airfoil at two different levels of accuracy to demonstrate its ability to detect areas in a two-dimensional design space where the surrogate model needs improvement to better drive the optimization process. 相似文献
5.
Digitization brings about new ways of analyzing data from cultural heritage areas. Automatic error detection, as input to semiautomatic error correction, is one type of analysis that can be found high on the priority list of cultural heritage data managers and researchers. We describe a general approach to cleaning cultural heritage databases. We present four case studies on databases from different cultural heritage institutions, and describe an information system in which we embed our error detector in a larger framework, enabling researchers to access, check, and correct their data more easily than before. 相似文献
6.
This small scale action research study investigated the experiences of learners over two iterations as they completed a patchwork text assignment within the digital medium of a personal learning system (PLS). The aim was to investigate the extent to which using a PLS can facilitate formative and collaborative feedback to assist student learning. A secondary question, linked to the course being a post graduate Certificate for new HE teachers within a geographically dispersed university, was to examine if using a PLS in the programme would influence their interest in using it with their own students in the future. This question is of particular importance for the tutors of this programme, as the university attracts mainly part-time students who are studying at a distance from the university campus. The study was carried out as part of the JISC funded Flourish Project, whose overall aim was to examine the use of a PLS to support the development of academic staff. 相似文献
7.
Caroline ConcattoAuthor VitaeJoão AlmeidaAuthor Vitae Guilherme FachiniAuthor VitaeMarcos HervéAuthor Vitae Fernanda KastensmidtAuthor Vitae Érika CotaAuthor VitaeMarcelo LubaszewskiAuthor Vitae 《Journal of Parallel and Distributed Computing》2011,71(5):664-674
We propose an effective and low cost method to increase the yield and the lifetime of torus NoCs. The method consists in detecting and diagnosing NoC interconnect faults using BIST structures and activating alternative paths for the faulty links. Alternative paths use the inherent redundancy of the torus topology, thus leading to minimal performance, area, and power overhead. We assume an extended interconnect fault model comprising stuck-at and pairwise shorts within a single link or between any two links in the network. Experimental results for a 3×3 NoC show that the proposed approach can correctly diagnose 93% of all possible interconnect faults and can mitigate 42% of those faults (representing 94.4% of the solvable faults) with a worst case performance penalty of 8% and 1% of area overhead. We also demonstrate the scalability of the method by presenting its application to larger NoCs. 相似文献
8.
A comprehensive quality model for service-oriented systems 总被引:2,自引:0,他引:2
In a service-oriented system, a quality (or Quality of Service) model is used (i) by service requesters to specify the expected
quality levels of service delivery; (ii) by service providers to advertise quality levels that their services achieve; and
(iii) by service composers when selecting among alternative services those that are to participate in a service composition.
Expressive quality models are needed to let requesters specify quality expectations, providers advertise service qualities,
and composers finely compare alternative services. Having observed many similarities between various quality models proposed
in the literature, we review these and integrate them into a single quality model, called QVDP. We highlight the need for
integration of priority and dependency information within any quality model for services and propose precise submodels for
doing so. Our intention is for the proposed model to serve as a reference point for further developments in quality models
for service-oriented systems. To this aim, we extend the part of the UML metamodel specialized for Quality of Service with
QVDP concepts unavailable in UML.
Ivan J. Jureta has, after graduating, summa cum laude, received the Master in Management and Master of International Management, respectively, at the Université de Louvain, Belgium, and the London School of Economics, both in 2005. He is currently completing his Ph.D. thesis at the University of Namur, Belgium, under Prof. Stéphane Faulkner’s supervision. His thesis focuses on quality management of adaptable and open service-oriented systems enabling the Semantic Web. Caroline Herssens received a Master Degree in Computer Science in 2005 at the Université de Louvain. In 2006, she graduated a Master in Business and Administration from the University of Louvain, with a supply chain management orientation. She is currently a teaching and research assistant and has started a Ph.D. thesis at the information systems research unit at Université de Louvain. Her research interests comprise service-oriented computing, conceptual modeling and information systems engineering. Stéphane Faulkner is an Associate Professor in Technologies and Information Systems at the University of Namur (FUNDP) and an Invited Professor at the Louvain School of Management of the Université de Louvain (UCL). His current research interests revolve around requirements engineering and the development of modeling notations, systematic methods and tool support for the development of multi-agent systems, database and information systems. 相似文献
Stéphane FaulknerEmail: |
Ivan J. Jureta has, after graduating, summa cum laude, received the Master in Management and Master of International Management, respectively, at the Université de Louvain, Belgium, and the London School of Economics, both in 2005. He is currently completing his Ph.D. thesis at the University of Namur, Belgium, under Prof. Stéphane Faulkner’s supervision. His thesis focuses on quality management of adaptable and open service-oriented systems enabling the Semantic Web. Caroline Herssens received a Master Degree in Computer Science in 2005 at the Université de Louvain. In 2006, she graduated a Master in Business and Administration from the University of Louvain, with a supply chain management orientation. She is currently a teaching and research assistant and has started a Ph.D. thesis at the information systems research unit at Université de Louvain. Her research interests comprise service-oriented computing, conceptual modeling and information systems engineering. Stéphane Faulkner is an Associate Professor in Technologies and Information Systems at the University of Namur (FUNDP) and an Invited Professor at the Louvain School of Management of the Université de Louvain (UCL). His current research interests revolve around requirements engineering and the development of modeling notations, systematic methods and tool support for the development of multi-agent systems, database and information systems. 相似文献
9.
User Activities Outliers Detection; Integration of Statistical and Computational Intelligence Techniques 下载免费PDF全文
In this article, a hybrid technique for user activities outliers detection is introduced. The hybrid technique consists of a two‐stage integration of principal component analysis and fuzzy rule‐based systems. In the first stage, the Hamming distance is used to measure the differences between different activities. Principal component analysis is then applied to the distance measures to find two indices of Hotelling's T2 and squared prediction error. In the second stage of the process, the calculated indices are provided as inputs to the fuzzy rule‐based systems to model them heuristically. The model is used to identify the outliers and classify them. The proposed system is tested in real home environments, equipped with appropriate sensory devices, to identify outliers in the activities of daily living of the user. Three case studies are reported to demonstrate the effectiveness of the proposed system. The proposed system successfully identifies the outliers in activities distinguishing between the normal and abnormal behavioral patterns. 相似文献
10.
Ziemkiewicz C Kosara R 《IEEE transactions on visualization and computer graphics》2008,14(6):1269-1276
The nature of an information visualization can be considered to lie in the visual metaphors it uses to structure information. The process of understanding a visualization therefore involves an interaction between these external visual metaphors and the user's internal knowledge representations. To investigate this claim, we conducted an experiment to test the effects of visual metaphor and verbal metaphor on the understanding of tree visualizations. Participants answered simple data comprehension questions while viewing either a treemap or a node-link diagram. Questions were worded to reflect a verbal metaphor that was either compatible or incompatible with the visualization a participant was using. The results suggest that the visual metaphor indeed affects how a user derives information from a visualization. Additionally, we found that the degree to which a user is affected by the metaphor is strongly correlated with the user's ability to answer task questions correctly. These findings are a first step towards illuminating how visual metaphors shape user understanding, and have significant implications for the evaluation, application, and theory of visualization. 相似文献