Quantitation of Cefaclor in Pharmaceutical Dosage Forms Using High Performance Liquid Chromatography

A stability-indicating high-performance liquid chromatography for the quantitation of cefaclor in pharmaceutical dosage forms has been developed. The method is accurate and precise with a percent relative standard deviation of 1.2 based on 5 readings. A number of inactive ingredients present in the capsules and suspensions did not interfere with the assay procedure. The extraction procedure from the dosage forms is very simple. The recovery from the synthetic mixtures was quantitative. The capsules which had expired 3 years ago lost only 3% of the potency. The drug appears to be very sensitive to strong acids or bases since a 5 minute boiling caused 100% degradation of drug in both the solutions.     

基于DSC控制的移相全桥DC/DC变换器

数字控制由于高集成度带来的低成本、设计沿继性、控制灵活等优点而应用逐渐广泛,电力电子应用逐渐朝着高频化方向发展,这也对高频开关电源的数字控制提出了要求。利用Freescale新型号数字信号控制器(DigitalSingnalController,DSC)MC56F8323的高性能特性,完成了基于DSC的带同步整流的高频软开关移相全桥变换器的数字控制,描述了DSC产生软件移相控制策略,并给出了详细的数字控制系统设计和软件结构设计,最后用一台500W实验样机验证了数字控制所带来的优良的系统性能。     

Mitigating the gateway bottleneck via transparent cooperative caching in wireless mesh networks

Wireless mesh networks (WMNs) have been proposed to provide cheap, easily deployable and robust Internet access. The dominant Internet-access traffic from clients causes a congestion bottleneck around the gateway, which can significantly limit the throughput of the WMN clients in accessing the Internet. In this paper, we present MeshCache, a transparent caching system for WMNs that exploits the locality in client Internet-access traffic to mitigate the bottleneck effect at the gateway, thereby improving client-perceived performance. MeshCache leverages the fact that a WMN typically spans a small geographic area and hence mesh routers are easily over-provisioned with CPU, memory, and disk storage, and extends the individual wireless mesh routers in a WMN with built-in content caching functionality. It then performs cooperative caching among the wireless mesh routers.We explore two architecture designs for MeshCache: (1) caching at every client access mesh router upon file download, and (2) caching at each mesh router along the route the Internet-access traffic travels, which requires breaking a single end-to-end transport connection into multiple single-hop transport connections along the route. We also leverage the abundant research results from cooperative web caching in the Internet in designing cache selection protocols for efficiently locating caches containing data objects for these two architectures. We further compare these two MeshCache designs with caching at the gateway router only.Through extensive simulations and evaluations using a prototype implementation on a testbed, we find that MeshCache can significantly improve the performance of client nodes in WMNs. In particular, our experiments with a Squid-based MeshCache implementation deployed on the MAP mesh network testbed with 15 routers show that compared to caching at the gateway only, the MeshCache architecture with hop-by-hop caching reduces the load at the gateway by 38%, improves the average client throughput by 170%, and increases the number of transfers that achieve a throughput greater than 1 Mbps by a factor of 3.     

Exploring the design space of reliable multicast protocols for wireless mesh networks

Many important applications in wireless mesh networks require reliable multicast communication, i.e., with 100% packet delivery ratio (PDR). Previously, numerous multicast protocols based on automatic repeat request (ARQ) have been proposed to improve the packet delivery ratio. However, these ARQ-based protocols can lead to excessive control overhead and drastically reduced throughput. In this paper, we present a comprehensive exploration of the design space for developing high-throughput, reliable multicast protocols that achieve 100% PDR.Motivated by the fact that 802.11 MAC layer broadcast, which is used by most wireless multicast protocols, offers no reliability, we first examine if better hop-by-hop reliability provided by unicasting the packets at the MAC layer can help to achieve end-to-end multicast reliability. We then turn to end-to-end solutions at the transport layer. Previously, forward error correction (FEC) techniques have been proved effective for providing reliable multicast in the Internet, by avoiding the control packet implosion and scalability problems of ARQ-based protocols. In this paper, we examine if FEC techniques can be equally effective to support reliable multicast in wireless mesh networks. We integrate four representative reliable schemes (one ARQ, one FEC, and two hybrid) originally developed for the Internet with a representative multicast protocol ODMRP and evaluate their performance.Our experimental results via extensive simulations offer an in-depth understanding of the various choices in the design space. First, compared to broadcast-based unreliable ODMRP, using unicast for per-hop transmission only offers a very small improvement in reliability under low load, but fails to improve the reliability under high load due to the significantly increased capacity requirement which leads to congestion and packet drop. Second, at the transport layer, the use of pure FEC can significantly improve the reliability, increasing PDR up to 100% in many cases, but can be inefficient in terms of the number of redundant packets transmitted. In contrast, a carefully designed ARQ–FEC hybrid protocol, such as RMDP, can also offer 100% reliability while improving the efficiency by up to 38% compared to a pure FEC scheme. To our best knowledge, this is the first in-depth study of high-throughput, reliable multicast protocols that provide 100% PDR for wireless mesh networks.     

可重定位的基于事务的系统级验证

功能验证已经成为开发SoC的主要问题。随着一些复杂SoC的规模超过两千万门，以及对开发和集成嵌入式软件的需求持续增加，软件模拟器已经力所不及。在设计过程需要几百万个时钟周期来充分测试和验证软件功能的情况下，软件仿真器的性能下降到1-5Hz。按照这种速率，软件调试需要几年的时     

The impact assessment we want

The impact assessment (IA) we want seeks to balance the ‘productive harmony’ between people and nature by enhancing the quality of life while maintaining the integrity of natural systems. Its focus centers on ‘sustainable futures’ as the goal of integrated IA.     

Authentication of borage oil

Over the past 30 years borage (Borago officinalis) has become established as a speciality oilseed crop grown exclusively for its oil, a rich source of gamma linolenic acid (GLA), C18 : 3n – 6. GLA is metabolised in the human body from linoleic acid and is itself a precursor in the formation of dihomo‐gammalinolenic acid, arachidonic acid and metabolites of these, prostaglandins, leukotrienes and thromboxanes. The oil is used extensively in the nutritional supplements, cosmetics and pet care industries primarily for its anti‐inflammatory and skin health properties. Global usage is estimated to be approximately 1000 tonnes per year and oil is usually traded on the basis of its GLA content with higher contents attracting a premium commercially. In recent years the development of competitively priced high GLA sources, particularly oils from genetically modified safflower have resulted in an increase in the aduleration of borage oil to raise GLA levels. Analytical and statistical techniques have now been developed to assist authenticating borage oil samples.