Differential transforming growth factor-beta secretion in adenocarcinoma and squamous cell carcinoma of the uterine cervix

Tumor cells from eight freshly isolated cervical cancers (i.e., four adenocarcinomas and four squamous carcinomas) were analyzed for their production of the immune-inhibitory cytokine transforming growth factor-beta (TGF-beta) in vitro. All fresh adenocarcinomas secreted significant levels of TGF-beta (mean 397, range between 207 and 782 pg/ml/10(5) cells/48 hr). In contrast, no detectable TGF-beta was present in the supernatants from the four fresh squamous carcinoma cultures (P < 0.001). These data suggest that major differences in the secretion of the immunoinhibitory cytokine TGF-beta exist between squamous cell carcinomas and adenocarcinomas of the uterine cervix. Furthermore, these findings suggest that at least some of the differences in the natural biologic behavior, as well as in the response to radiation treatment, between these two histologic types of cervical cancer could be related to differences in secretion of this immune-inhibitory cytokine.     

Theoretical and experimental analyses of rheological,compatibility and mechanical properties of PVMQ/XNBR-g GMA/XNBR/GO ternary hybrid nanocomposites

Iranian Polymer Journal - Effects of graphene oxide (GO) on various properties of rubber hybrid nanocomposites based on PVMQ/XNBR-g-GMA/XNBR (phenyl-vinyl-methyl-polysiloxane/carboxylated nitrile...     

Robust self-stabilizing weight-based clustering algorithm

Ad hoc networks consist of wireless hosts that communicate with each other in the absence of a fixed infrastructure. Such networks cannot rely on centralized and organized network management. The clustering problem consists of partitioning network nodes into non-overlapping groups called clusters. Clusters give a hierarchical organization to the network that facilitates network management and that increases its scalability.In a weight-based clustering algorithm, the clusterheads are selected according to their weight (a node’s parameter). The higher the weight of a node, the more suitable this node is for the role of clusterhead. In ad hoc networks, the amount of bandwidth, memory space or battery power of a node could be used to determine weight values.A self-stabilizing algorithm, regardless of the initial system configuration, converges to legitimate configurations without external intervention. Due to this property, self-stabilizing algorithms tolerate transient faults and they are adaptive to any topology change.In this paper, we present a robust self-stabilizing weight-based clustering algorithm for ad hoc networks. The robustness property guarantees that, starting from an arbitrary configuration, after one asynchronous round, the network is partitioned into clusters. After that, the network stays partitioned during the convergence phase toward a legitimate configuration where the clusters verify the “ad hoc clustering properties”.     

Discharge suppression in the silent interval preceding the tone burst in pause-build units of the dorsal cochlear nucleus of the unanesthetized decerebrate cat

A recent intracellular study of dorsal cochlear nucleus (DCN) neurons in vitro by Manis [P. B. Manis, J. Neurosci. 10, 2338-2351 (1990)] suggests that the expression of the pause-build discharge pattern is in large part dependent on hyperpolarization of their membrane potentials in a period just preceding a depolarizing stimulus ("hyperpolarization conditioning" hypothesis). Our examination of the activity of a sample of pause-build units (n = 72) revealed suppression of discharge activity during a time window of the silent interstimulus interval (SII) just preceding the tone burst relative to the spontaneous rate in 74% of all units. The discharge suppression of a subset of DCN pause-build units in the SII satisfies a requirement of the "hyperpolarization conditioning" hypothesis, and thus supports the hypothesis.     

Coating Effects on Transient Cooling a Hot Spherical Body

A numerical solution is carried out to treat the transient cooling problem with conduction and radiation for a hot spherical body covered with a cold coating material. The solution includes the equations of radiative transfer, coupled with a transient energy equation that contains both radiative and conductive terms. The radiative transfer equation was solved by the discrete ordinates method, and a parmetric study was performed by changing various physical parameters such as the optical thicknesses, thermal conductivity of the coating, emissivity, and diffusivity of the sphere. It was found that the properties of the coating have a direct effect on the cooling rate of the sphere.     

A 2 MV Van de Graaff accelerator as a tool for planetary and impact physics research

Investigating the dynamical and physical properties of cosmic dust can reveal a great deal of information about both the dust and its many sources. Over recent years, several spacecraft (e.g., Cassini, Stardust, Galileo, and Ulysses) have successfully characterised interstellar, interplanetary, and circumplanetary dust using a variety of techniques, including in situ analyses and sample return. Charge, mass, and velocity measurements of the dust are performed either directly (induced charge signals) or indirectly (mass and velocity from impact ionisation signals or crater morphology) and constrain the dynamical parameters of the dust grains. Dust compositional information may be obtained via either time-of-flight mass spectrometry of the impact plasma or direct sample return. The accurate and reliable interpretation of collected spacecraft data requires a comprehensive programme of terrestrial instrument calibration. This process involves accelerating suitable solar system analogue dust particles to hypervelocity speeds in the laboratory, an activity performed at the Max Planck Institut fu?r Kernphysik in Heidelberg, Germany. Here, a 2 MV Van de Graaff accelerator electrostatically accelerates charged micron and submicron-sized dust particles to speeds up to 80 km s(-1). Recent advances in dust production and processing have allowed solar system analogue dust particles (silicates and other minerals) to be coated with a thin conductive shell, enabling them to be charged and accelerated. Refinements and upgrades to the beam line instrumentation and electronics now allow for the reliable selection of particles at velocities of 1-80 km s(-1) and with diameters of between 0.05 μm and 5 μm. This ability to select particles for subsequent impact studies based on their charges, masses, or velocities is provided by a particle selection unit (PSU). The PSU contains a field programmable gate array, capable of monitoring in real time the particles' speeds and charges, and is controlled remotely by a custom, platform independent, software package. The new control instrumentation and electronics, together with the wide range of accelerable particle types, allow the controlled investigation of hypervelocity impact phenomena across a hitherto unobtainable range of impact parameters.     

Mechanical properties of continuous bamboo fiber-reinforced biobased polyamide 11 composites

This study is devoted to the analysis of the properties of continuous bamboo fiber (BF)-reinforced polyamide 11 (PA 11) composites. The SEM observations highlighted continuity between BFs and the polymeric matrix showing a high density of hydrogen bonds. The comparative calorimetric study of the matrix and its composites showed that the crystallinity of PA 11 was not modified by the presence of bamboo fibers. The physical aging observed in PA 11 is no more observed in composites due to physical interactions between PA 11 and BFs. The mechanical properties were investigated by tensile strength and dynamic mechanical analysis. The introduction of BFs enhanced Young's modulus of the matrix by a factor of 10. The presence of BFs also improved the storage shear modulus G′ over the whole temperature range. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47623.     

Influence of new thermoplastic sizing agents on the mechanical behavior of poly(ether ketone ketone)/carbon fiber composites

In this study, unidirectional poly(ether ether ketone)/carbon fiber (CF) composite sheets were elaborated with unsized, epoxy‐sized, and thermoplastic‐sized CFs by hot‐press molding. The thermoplastic sizings that we used were poly(ether imide) (PEI) and poly(ether ketone ketone) oligomer aqueous dispersions. Scanning electron microscopy observation of the composites freeze fractures showed that unlike unsized or epoxy‐sized CFs, the thermoplastic sizings improved the interaction between the fibers and the matrix. A comparative study of the mechanical relaxations by dynamic mechanical analysis was carried out on the different composites before and after immersion in kerosene. At low temperature, the PEI sizing had a significant influence on the β relaxation, particularly after kerosene immersion. The thermoplastic sizings did not modify the glass‐transition temperature but improved the kerosene resistance on the composites. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42550.