Inhibition of 2-nitropropane-induced rat liver DNA and RNA damage by benzyl selenocyanate

We observed that pretreatment of male F344 rats with benzyl selenocyanate, a versatile organoselenium chemopreventive agent in several animal model systems, decreases the levels of DNA and RNA modifications produced in the liver by the hepatocarcinogen 2-nitropropane. To clarify the mechanisms involved, we pretreated male F344 rats with either benzyl selenocyanate, its sulfur analog benzyl thiocyanate, phenobarbital or cobalt protoporphyrin IX; the latter is a depletor of P450. We then determined (1) the ability of liver microsomes to denitrify 2-nitropropane, (2) effects on 2-nitropropane-induced liver DNA and RNA modifications and (3) amount of nitrate excreted in rat urine following administration of the carcinogen. Pretreatment with benzyl selenocyanate or phenobarbital increased the denitrification activity of liver microsomes by 217 and 765%, respectively, increased liver P4502B1 by 31- and 435-fold, respectively, decreased the levels of 2-nitropropane-induced modifications in liver DNA (29-70% and 17-30%, respectively) and RNA (67-85% and 30-50%, respectively), and increased the 24-h urinary excretion of nitrate by 157 and 209%, respectively. Pretreatment with benzyl thiocyanate had no significant effect on any of these parameters. Pretreatment with cobalt protoporphyrin IX decreased liver P4502B 1 by 87%, decreased the denitrification activity of liver microsomes by 76%, decreased the 24 h urinary excretion of nitrate by 88.5%, but increased the extent of 2-nitropropane-induced liver nucleic acid modifications by 17-67%. These results indicate that the metabolic sequence from 2-nitropropane to the reactive species causing DNA and RNA modifications does not involve the removal of the nitro group. Moreover, they suggest that benzyl selenocyanate inhibits 2-NP-induced liver nucleic acid modifications in part by increasing its detoxication through induction of denitrification, although it is evident that other mechanisms must also be involved.     

Dicyanate semi IPNs—A new class of high performance,high temperature plastics

Dicyanate Semi-Interpenetrating Polymer Networks (semi IPNs) are made by dissolving a thermoplastic in crosslinking dicyanates and then curing the resulting mixture. The semi IPNs produced are strong, with tensile strengths of 10,000 to 12,000 psi, and flexible, with elongations to break of 10 to 17 percent. Dicyanate semi IPNs also have good thermal stability and the softening temperatures of the IPNs are significantly, higher than those of the corresponding thermoplastics.     

AA4343/AA3003铝合金薄板钎焊接头的显微组织特征

采用气氛保护钎焊工艺 ,对AA434 3/AA30 0 3铝合金复合板材料的钎焊接头组织特征 ,及其与焊接工艺的关系和对接头区显微硬度的影响进行了研究。实验结果表明 ,钎焊过渡区由单相α(Al)固溶体层和Si扩散层组成 ,它们的厚度随钎焊条件而发生变化。远离焊接区有一个α(Al)固溶体残余层 ,它的厚度保持 2 0 μm基本不变 ,与焊接参数和材料性质无关。讨论了钎焊接头特征组织的形成机理     

Information Retrieval and Filtering of Multimedia Mineral Data

Most of the written materials are consisted of Multimedia (MM) information because beside text usually contain image information. The present information retrieval and filtering systems use only text parts of the documents or in best case images represented by keywords or image captions. Why do not use both, text and image features of the documents and in the retrieval or filtering process utilize more completely the document information content? Can such approach increase the effectiveness of retrieval and filtering processes? There is a very little difference between retrieval and filtering at an abstract level. In this paper, we will discuss some possible similarities and differences between them on the application level taking into account the experiments in retrieval and filtering of multimedia mineral information.     

Comparing Universal Covers in Polynomial Time

The universal cover T _G of a connected graph G is the unique (possibly infinite) tree covering G, i.e., that allows a locally bijective homomorphism from T _G to G. It is well-known that if a graph G covers a graph H, then their universal covers are isomorphic, and that the latter can be tested in polynomial time by checking if G and H share the same degree refinement matrix. We extend this result to locally injective and locally surjective homomorphisms by following a very different approach. Using linear programming techniques we design two polynomial time algorithms that check if there exists a locally injective or a locally surjective homomorphism, respectively, from a universal cover T _G to a universal cover T _H (both given by their degree matrices). This way we obtain two heuristics for testing the corresponding locally constrained graph homomorphisms. Our algorithm can also be used for testing (subgraph) isomorphism between universal covers, and for checking if there exists a locally injective or locally surjective homomorphism (role assignment) from a given tree to an arbitrary graph H.     

Parameterized complexity of coloring problems: Treewidth versus vertex cover

We compare the fixed parameter complexity of various variants of coloring problems (including List Coloring, Precoloring Extension, Equitable Coloring, L(p,1)-Labeling and Channel Assignment) when parameterized by treewidth and by vertex cover number. In most (but not all) cases we conclude that parametrization by the vertex cover number provides a significant drop in the complexity of the problems.     

Periodic material structures tested by the noise spectroscopy method

The authors discuss the testing of periodic materials and structures via noise spectroscopy as an alternative to frequency sweep spectral analyzers, and the presented procedure employs the various advantages offered by a wide spectrum signal a Generally, noise spectroscopy tests are carried out to verify the behaviour of the response of periodic structures, and the related objective consists in recording the properties of microscopic structures in natural and artificial materials. The aim is to propose and verify a high-precision metrological method utilizable for the investigation of structures and materials in the frequency range between 100 MHz and 10 GHz; this paper therefore characterizes the design of a suitable measuring technique based on noise spectroscopy. In this context, the applied equipment is also shown to complement the underlying theoretical analysis.     

Substitution bias and the construction of a spatial cost of living index*

We estimate the spatial substitution bias based on the difference between a price index (PI) and the true cost of living (COL). This bias is computed at three geographical scales, using several fixed baskets and across different expenditures quartiles. Our results show a significant substitution bias for small geographical units. The choice of the base basket is also relevant for the bias estimation. Finally, the spatial substitution bias is larger for upper side of the expenditure distribution due to the heterogeneity in the consumption basket. This exercise shows that the spatial dimension affects the construction of a price index and that the approach of fixed baskets should be carefully considered in the estimation of spatial price differentials.