Hull-form stochastic optimization via computational-cost reduction methods

In this paper, analytical functions for the estimation of the temperature-dependent behaviors of poorly and highly dispersed graphene oxide reinforced nanocomposite (GORNC) materials are studied in the framework of a machine learning-based approach. The validity of the presented models is shown comparing the results achieved from this modeling with those reported in the open literature. Also, the application of the obtained functions in solving the thermal buckling problem of beams constructed from such nanocomposites is demonstrated based on an energy-based method incorporated with a shear deformable beam hypothesis. The verification of the results indicates that the presented mechanical model can approximate the buckling behaviors of nanocomposite beams with remarkable precision. It can be realized from the results that the temperature plays an indispensable role in the determination of the buckling load which can be endured by the nanocomposite structure.

     

High-Energy Physics on the Grid: the ATLAS and CMS Experience

In this paper we present the experience of the ATLAS and CMS High-Energy Physics (HEP) experiments at the Large Hadron Collider (LHC) with the LCG/EGEE Grid infrastructure. The activity developed around the following two main lines: large-scale physics and detector simulations and end-user analysis. The LCG/EGEE Grid infrastructure offers a large amount of computing and storage resources and is growing very rapidly. It provides the natural environment for large-scale physics and detector simulations. Also, the analysis of these detector simulation data (and in the near future of the reconstructed data from physics collisions) requires efficient end-users access to Grid resources. In this paper, the main findings and lessons learned in terms of performance, robustness and scalability of the whole system are discussed in detail.     

Campylobacter jejuni loss of culturability in aqueous microcosms and ability to resuscitate in a mouse model

Water is known as one of the main transmission routes of Campylobacter and contributes to increase the number of sporadic infections and outbreaks. Campylobacter jejuni persists in the environment, especially in water, in a viable but non-culturable (VBNC) form that is thought to be a possible cause of water-borne outbreaks. In this study, we evaluated the loss of culturability and viability of 9 C. jejuni strains of clinical origin and one ATCC reference strain when kept at 4 degrees C in artificial sea water (ASW). Culturability was measured as colony-forming units while viability was evaluated by CTC-DAPI double staining and the combined CTC-specific fluorescent antibody technique (CTC-FA). When cultured on Columbia Agar plates, strains exhibited different growth profiles which allowed to classify them into three different groups. Both techniques used to monitor the viability of the bacterial cells showed that C. jejuni strains survived in the VBNC form in the microcosms through a period lasting from 138 to 152 days. The recovery of C. jejuni VBNC forms to culturability, as evidenced by cell division, was obtained by passage in the mouse intestine. Our results indicate that C. jejuni VBNC cells were able to remain in this state for a few months and regain their culturability after in vivo passage depending on their lasting in the VBNC state, which affects the number of respiring bacteria. In fact, the resuscitation was achieved when the number of respiring bacteria became higher than 10(4) cell/ml. Therefore, a relatively high microbial titer of respiring bacteria in the VBNC state seems to be important for the resuscitation and subsequent intestinal colonisation.     

Irradiation testing of design models for the GCFR fuel pressure equalization (vent) system

The major consideration in the design of the pressure equalization system for the gas-cooled fast breeder reactor is the release and venting of gaseous and volatile fission products. Single vented rods have been irradiated in the thermal flux of the Oak Ridge Research Reactor (ORR) at GCFR operating conditions of 12–15 kW/ft and 565–685°C cladding outside temperature to determine the fission product release and to verify the design concept. Results obtained to date from measurements of fission gas release and transport have been compared with predictions based on design assumptions to verify analytical models and have established a degree of conservatism of design assumptions.The release of radioactive gases from the fuel matrix was measured directly at 12 kW/ft in an operating fuel rod and was found to be significantly less than the design assumption of 100% instantaneous release and less than predictions using the diffusion model with Findlay's coefficients. Although solid state diffusion was found to be the dominant process delaying the venting of fission gases in the experimental irradiation, fission gas interdiffusion in helium will be the dominant venting transport process for the reactor design. Delay of fission gases by adsorption on charcoal was verified at trap operating temperatures for burn-ups up to 54 000 MWd/t. Volatile fission products (cesium and iodine) did not migrate beyond the fuel-blanket interface. The feasibility of the vented-fuel-rod design concept has been established.     

Sensitivity Analysis Methods to Design Optimal Ship Hulls

Automatic procedures for the design of ship hull geometries yielding minimal wave resistance and wave breaking are an attractive opportunity from both the economical and practical standpoints. Estimating the cost function gradient according to the Sensitivity Equation and Adjoint Methods (SEM, AM) instead of using the standard finite difference approximations has the potential of reducing the computational cost of the overall optimization procedure. Aim of this paper is to assess the actual extent of the cost reduction. Speed-up factors of up to 3.3 have been obtained in the evaluation of the cost function gradient and of about 1.6 in the overall optimization procedure applied to an optimal shape design problem of an existing tanker ship. The SEM and AM methods perform better than finite differences mainly because of (i) the smaller number of flow solutions needed to compute the cost function gradient and (ii) the opportunity of using the same LU factored matrix for both the flow solver and the SEM or AM equations, a circumstance arising as a consequence of having chosen a linearized potential flow model of the 3D free-surface problem.     

Hydroelastic optimization of a keel fin of a sailing boat: a multidisciplinary robust formulation for ship design

The paper presents a formulation for multidisciplinary design optimization of vessels, subject to uncertain operating conditions. The formulation couples the multidisciplinary design analysis with the Bayesian approach to decision problems affected by uncertainty. In the present context, the design specifications are no longer given in terms of a single operating design point, but in terms of probability density function of the operating scenario. The optimal configuration is that which maximizes the performance expectation over the uncertain parameters variation. In this sense, the optimal solution is “robust” within the stochastic scenario assumed. Theoretical and numerical issues are addressed and numerical results in the hydroelastic optimization of a keel fin of a sailing yacht are presented.     

Extensive N‐methylation of chitosan: evaluating the effects of the reaction conditions by using response surface methodology

The effects of reaction time, concentration of aqueous sodium hydroxide and molar ratio iodomethane/chitosan on the yield of the reaction of chitosan with iodomethane in N‐methyl‐2‐pyrrolidone (NMP) at 25.0 ± 0.1 °C, as well as on the characteristics of the resulting N,N,N‐trimethylchitosan (TMCh), were evaluated by using full‐factorial 2³ design analysis and response surface methodology. This study also aimed to determine the reaction conditions allowing the production of water‐soluble TMCh presenting a high average degree of quaternization and intrinsic viscosity at high reaction yield. ¹H NMR spectroscopy was employed for structural characterization, including the determination of average degrees of acetylation () and quaternization (), while capillary viscometry was used to determine intrinsic viscosity [η]. The results show that when the extensive N‐methylation is carried out for 24 h in NMP/15% NaOH (w/v) employing a lower excess of iodomethane (CH₃I/Ch = 9), water‐soluble highly substituted ( = 46.0%) TMCh ([η] = 213.0 mL g^?1) can be produced in high yield (81.8%). The highly significant mathematical models resulting from this study describe the dependence of the experimental responses on the reaction conditions and allow the characteristics and properties of the resulting TMCh to be defined by properly choosing the reaction conditions. © 2015 Society of Chemical Industry     

A gradient-based path optimization method for motion planning

Most algorithms in probabilistic sampling-based path planning compute collision-free paths made of straight line segments lying in the configuration space. Due to the randomness of sampling, the paths make detours that need to be optimized. The contribution of this paper is to propose a basic gradient-based algorithm that transforms a polygonal collision-free path into a shorter one. While requiring only collision checking, and not any time-consuming obstacle distance computation nor geometry simplification, we constrain only part of the configuration variables that may cause a collision, and not entire configurations. Thus, parasite motions that are not useful for the problem resolution are reduced without any assumption. Experimental results include navigation and manipulation tasks, eg a manipulator arm-filling boxes and a PR2 robot working in a kitchen environment. Comparisons with a random shortcut optimizer and a partial shortcut have also been studied.     

Identification and functional traits of lactic acid bacteria isolated from Ciauscolo salami produced in Central Italy

Lactic acid bacteria (LAB) from Ciauscolo salami produced in Marche Region of Central Italy, and LAB strains belonging to our laboratory collection were examined for their capability to survive at low pH and bile, to adhere to Caco-2 cells, and for antibiotic resistance. LAB from Ciauscolo were identified by ARDRA and RAPD-PCR. Our study showed that all LAB strains had good adaptation to gastric juice and moderate tolerance to bile. The adhesiveness was variable among strains but significantly lower in LAB from food. Antibiotic resistance was broadly spread among food strains, with level of resistance exceeding 15% for all the antibiotics tested. The resistance determinants erm(B) and tet(M) were found in nine strains of food origin (21.4%) while tet(L) in one strain of our collection (5%). Our work suggests that fermented foods are valuable sources of bacterial strains with functional traits of intestinal lactobacilli. These bacteria may be further studied for their use in probiotic applications.     

Value of right ventricular ejection fraction in predicting short-term prognosis of patients with severe chronic heart failure

BACKGROUND: The prognosis of chronic heart failure has been studied extensively, but factors predicting short-term outcome in patients with severe chronic heart failure are still poorly defined, and the current indications for heart transplantation as a treatment for end-stage heart failure need on objective analysis. METHODS: Purpose of the study was to identify the determinants of short-term prognosis in a group of 142 consecutive ambulatory patients (mean age 49.8 +/- 11 years). Referred for heart transplantation because of severe chronic heart failure, the patients were admitted with left ventricular ejection fraction markedly depressed and had had symptoms in spite of an optimal standardized medical therapy for at least 1 month. Baseline clinical and instrumental evaluation included right-sided heart catheterization with a flow-directed multilumen thermodilution catheter, which enables determination of pressures, cardiac output, right ventricular volumes, and ejection fraction. RESULTS: Most patients were in New York Heart Association class III (61%) and IV (24%), and the hemodynamic profile was characterized by mean left ventricular ejection fraction of 20.2% +/- 6%, cardiac index of 2.13 +/- 0.6 l/min/m2, pulmonary capillary wedge pressure of 23.1 +/- 11 mm Hg, right atrial pressure of 7.9 +/- 6 mm Hg, right ventricular ejection fraction of 23.2% +/- 12.4%. During a mean follow-up of 11.1 +/- 9.4 months, 33 patients underwent transplantation (23.4%), 41 died (28.8%), and 68 were still alive (47.8%). There was a substantial overlap in left ventricular ejection fraction between patients divided on the basis of outcome, whereas right ventricular ejection fraction was significantly lower in patients who died or underwent transplantation. Cox multivariate analysis showed three independent prognostic variables: cause (p = 0.03), heart failure score (p = 0.001), and right ventricular ejection fraction (p = 0.000). Short-term survival (10 months) was significantly (p = 0.000) different in patients with > or = 24% or < 24% right ventricular ejection fraction. Statistical analysis identified right ventricular ejection fraction as the single variable to be highly correlated with an increased risk of early death. CONCLUSIONS: This study suggests that right ventricular function is a crucial determinant of short-term prognosis in severe chronic heart failure. Statistical analysis identified right ventricular ejection fraction, determined by thermodilution during right-sided heart catheterization, as the single most important predictor of short-term prognosis in a large cohort of patients who had symptoms in spite of a standardized, optimized, multipharmacologic treatment. The variable allows a useful risk stratification in patients with severe chronic heart failure and uniformly depressed left ventricular ejection fraction and provides guidance in the assessment of indications and timing for transplantation.