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1.
Microsystem Technologies - The original version of this article unfortunately contained a mistake. Farzad Ebrahimi was not listed among the authors.  相似文献   
2.
The association between obesity, cancer and cardiovascular disease (CVD) has been demonstrated in animal and epidemiological studies. However, the specific role of visceral obesity on cancer and CVD remains unclear. Visceral adipose tissue (VAT) is a complex and metabolically active tissue, that can produce different adipokines and hormones, responsible for endocrine-metabolic comorbidities. This review explores the potential mechanisms related to VAT that may also be involved in cancer and CVD. In addition, we discuss the shared pharmacological treatments which may reduce the risk of both diseases. This review highlights that chronic inflammation, molecular aspects, metabolic syndrome, secretion of hormones and adiponectin associated to VAT may have synergistic effects and should be further studied in relation to cancer and CVD. Reductions in abdominal and visceral adiposity improve insulin sensitivity, lipid profile and cytokines, which consequently reduce the risk of CVD and some cancers. Several medications have shown to reduce visceral and/or subcutaneous fat. Further research is needed to investigate the pathophysiological mechanisms by which visceral obesity may cause both cancer and CVD. The role of visceral fat in cancer and CVD is an important area to advance. Public health policies to increase public awareness about VAT’s role and ways to manage or prevent it are needed.  相似文献   
3.
Dietary energy restriction was previously shown to be effective in preventing a wide range of experimentally induced cancers. Studies were conducted to assess the influence on pancreatic carcinogenesis of dietary energy restrictions (reduced fat and carbohydrate) of 10%, 20% or 40% in comparison with control in Syrian hamsters treated with N-nitrosobis(2-oxopropyl)amine (BOP). Two carcinogenesis studies were conducted. One used a single treatment with 20 mg BOP/kg body weight and followed hamsters for 102 weeks following treatment, and the other used three weekly treatments of 20 mg BOP/kg body weight and followed hamsters for 45 weeks after treatment. Hamsters were fed control or energy restricted diet beginning the week following the last BOP treatment. Pancreatic carcinomas were induced in 9-18% of the hamsters in the first experiment and in 59-66% of the animals in the second. Dietary energy restriction did not influence carcinoma incidence in either study, and in the second experiment the multiplicity of tumors was higher in the 40% energy restriction (ER) group than in control hamsters. Plasma corticosterone was suppressed by BOP treatment, particularly in the 20% and 40% ER hamsters in the second experiment, and diet or BOP treatment did not significantly alter plasma cortisol. Pancreatic protein kinase Czeta measured by Western blot was highest in the cytosol and particulate fractions of the 40% ER hamsters in the first experiment. These results indicate that dietary energy restriction is not effective in the prevention of BOP induced pancreatic carcinogenesis in the Syrian hamster.  相似文献   
4.
Imaging resolution in optical coherence tomography (OCT) is a key determinant for acquiring clinically useful optical biopsies of tissues. In contrast to light or confocal microscopy, the axial and transverse resolutions in OCT are independent and each can be analyzed individually. A method for mitigating transverse blurring and the apparent loss of transverse resolution in OCT by means of Gaussian beam deconvolution is presented. Such a method provides better representation of a specimen by using known physical parameters of a lens. To implement this method, deconvolution algorithms based on a focal-dependent kernel are investigated. First, the direct inverse problem is investigated using two types of regularization, truncated singular value decomposition, and Tikhonov. Second, an iterative expectation maximization algorithm, the Richardson-Lucy algorithm, with a beam-width-dependent iteration scheme is developed. A dynamically iterative Richardson-Lucy algorithm can reduce transverse blurring by providing an improvement in the transverse point-spread-function for sparse scattering samples in regions up to two times larger than the confocal region of the lens. These deblurring improvements inside and outside of the confocal region, which are validated experimentally, are possible without introducing new optical imaging hardware or acquiring multiple images of the same specimen. Implementation of this method in sparse scattering specimens, such as engineered tissues, has the potential to improve cellular detection and categorization.  相似文献   
5.
The sinuous antennas have a numerous applications in military and civil systems such as direction finding systems and reflector feeds due to their superior broadband characteristics and simultaneous polarization capability. In this paper, design, construction and measurements of planar sinuous antennas are investigated for 1–5 GHz frequency range. Feeding sections of this antenna are realized by using microstrip tapered baluns. We have determined the microstrip tapered balun dimensions using Ansoft HFSS-simulation program. The performances of the manufactured antenna are measured using HP vector network analyzer. Polarization patterns and return loss characteristics of the designed antenna that have been measured in anechoic chamber, are presented.  相似文献   
6.
Four normal pancreas, 8 chronic pancreatitis specimens, and 30 non-endocrine pancreatic tumors from humans and 6 normal and 6 induced pancreatic cancers in hamsters were examined immunohistochemically by antibodies against human transforming growth factor-alpha (TGF-alpha) and epidermal growth factor receptor (EGFR). Two normal pancreas and two pancreatic cancer specimens from each species were also studied immunoelectron microscopically by the immunogold method. In chronic pancreatitis, the reactivity and intensity of the staining with both antibodies were much greater in ductal/ductular cells than in the normal pancreas. All 30 pancreatic cancers reacted with both antibodies with a variable degree of reactivity and staining intensity. No correlation was found between the histological type of tumors, the degree of tumor differentiation, and the incidence and patterns of reactivity of either antibody. Immunoelectron microscopically, both EGFR and TGF-alpha were demonstrated primarily on the basal membrane. In the normal hamster pancreas, TGF-alpha was overexpressed in the alpha-cells but not in any other islet cells. Both TGF-alpha and EGFR were marginally detectable in the exocrine pancreas and in induced pancreatic lesions. This is the first demonstration of subcellular localization of TGF-alpha and EGFR in the normal and diseased human and hamster pancreas.  相似文献   
7.

An analytical answer to the buckling problem of a composite plate consisted of multi-scale hybrid nanocomposites is presented here for the first time. In other words, the constituent material of the structure is made of an epoxy matrix which is reinforced by both macro- and nanosize reinforcements, namely, carbon fiber (CF) and carbon nanotube (CNT). The effective material properties such as Young’s modulus or density are derived utilizing a micromechanical scheme incorporated with the Halpin–Tsai model. To present a more realistic problem, the plate is placed on a two-parameter elastic substrate. Then, on the basis of an energy-based Hamiltonian approach, the equations of motion are derived using the classical theory of plates. Finally, the governing equations are solved analytically to obtain the critical buckling load of the system. Afterward, the normalized form of the results is presented to emphasize the impact of each parameter on the dimensionless buckling load of composite plates. It is worth mentioning that the effects of various boundary conditions are covered, too. To show the efficiency of presented modeling, the results of this article are compared to those of former attempts.

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8.

In this study postbuckling behaviors of multiscale composite sandwich doubly curved piezoelectric shell with a flexible core and MR layers by employing Homotopy Perturbation Method in hygrothermal environment has been investigated. By using Reddy third shear deformable theory the face sheets and third-order polynomial theory of the flexible core the strains and stresses are obtained. A mathematical model for the multiscale composite layered shell with a flexible core and magnetorheological layer (MR) that incorporates the nonlinearity of the in-plane and the vertical displacements of the core is assumed. Three-phase composite shells with polymer/Carbon nanotube/fiber and polymer/Graphene platelet/fiber either uniformly or non-uniformly based on different patterns according to Halpin–Tsai model have been considered. The governing equations of multiscale shell have been derived by implementing Hamilton’s principle. Meanwhile, simply supported boundary conditions are employed to the shell. For investigating correctness and accuracy, this paper is validated by other previous researches. Finally, different parameters such as temperature rise, various distribution patterns, magnetic fields and curvature ratio are considered in this article. It is found these parameters have significant effect on the frequency–amplitude curves.

  相似文献   
9.
Journal of Computational Electronics - In recent years, cloaking using materials with negative electric permittivity or magnetic permeability has been studied and researched. It has been...  相似文献   
10.
Video indexing is employed to represent the features of video sequences. Motion vectors derived from compressed video are preferred for video indexing because they can be accessed by partial decoding; thus, they are used extensively in various video analysis and indexing applications. In this study, we introduce an efficient compressed domain video indexing method and implement it on the H.264/AVC coded videos. The video retrieval experimental evaluations indicate that the video retrieval based on the proposed indexing method outperforms motion vector based video retrieval in 74 % of queries with little increase in computation time. Furthermore, we compared our method with a pixel level video indexing method which employs both temporal and spatial features. Experimental evaluation results indicate that our method outperforms the pixel level method both in performance and speed. Hence considering the speed and precision characteristics of indexing methods, the proposed method is an efficient indexing method which can be used in various video indexing and retrieval applications.  相似文献   
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