Developments in high-resolution positron emission tomography at MGH

The development of high resolution PET systems is important for the wider application of this techniques. The resolution of PET is limited by a number of physical factors such as positron range, small angle deviation, and sampling frequency. The design of the detector array and its sensitivity remain critical factors; designs incorporating analog coding have proven to be useful. PCR-I, a single plane PET system, has demonstrated the concept and has produced useful images in animal studies. PCR-II will extend the concept to a two dimensional detector array resulting in a system with high resolution and high sensitivity.     

Estimating confidence intervals for cost-effectiveness ratios: an example from a randomized trial

Cost-effectiveness ratios usually appear as point estimates without confidence intervals, since the numerator and denominator are both stochastic and one cannot estimate the variance of the estimator exactly. The recent literature, however, stresses the importance of presenting confidence intervals for cost-effectiveness ratios in the analysis of health care programmes. This paper compares the use of several methods to obtain confidence intervals for the cost-effectiveness of a randomized intervention to increase the use of Medicaid's Early and Periodic Screening, Diagnosis and Treatment (EPSDT) programme. Comparisons of the intervals show that methods that account for skewness in the distribution of the ratio estimator may be substantially preferable in practice to methods that assume the cost-effectiveness ratio estimator is normally distributed. We show that non-parametric bootstrap methods that are mathematically less complex but computationally more rigorous result in confidence intervals that are similar to the intervals from a parametric method that adjusts for skewness in the distribution of the ratio. The analyses also show that the modest sample sizes needed to detect statistically significant effects in a randomized trial may result in confidence intervals for estimates of cost-effectiveness that are much wider than the boundaries obtained from deterministic sensitivity analyses.     

Performance characteristics of a whole-body PET scanner

METHODS: This study characterizes the performance of a newly developed whole-body PET scanner (Advance, General Electric Medical Systems, Milwaukee, WI). The scanner consists of 12,096 bismuth germinate crystals (4.0 mm transaxial by 8.1 mm axial by 30 mm radial) in 18 rings, giving 35 two-dimensional image planes through an axial field of view of 15.2 cm. The rings are separated by retractable tungsten septa. Intrinsic spatial resolution, scatter fraction, sensitivity, high count rate performance and image quality are evaluated. RESULTS: Transaxial resolution (in FWHM) is 3.8 mm at the center and increases to 5.0 mm tangential and 7.3 mm radial at R = 20 cm. Average axial resolution decreases from 4.0 mm FWHM at the center to 6.6 mm at R = 20 cm. Scatter fraction is 9.4% and 10.2% for direct and cross slices, respectively. With septa out, the average scatter fraction is 34%. Total system sensitivity for true events (in kcps/(microCi/cc)) is 223 with septa in and 1200 with septa out. Dead-time losses of 50% correspond to a radioactivity concentration of 4.9 (0.81) microCi/cc and a true event count rate of 489 (480) kcps with septa in (out). Noise-equivalent count rate (NECR) for the system as a whole shows a maximum of 261 (159) kcps at a radioactivity concentration of 4.1 (0.65) microCi/cc with septa in (out). NECR is insensitive to changes in lower gamma-energy discrimination between 250-350 keV. CONCLUSIONS: The results show the performance of the newly designed PET scanner to be well suited for clinical and research applications.     

Charnley total hip arthroplasty in patients less than fifty years old. A twenty to twenty-five-year follow-up note

We evaluated the results twenty to twenty-five years after ninety-three consecutive, nonselected Charnley total hip arthroplasties performed with cement by the senior one of us in sixty-nine patients who were less than fifty years old at the time of the procedure. Seventy of the seventy-two hips in the living patients were followed radiographically for at least twenty years. Twenty-seven hips (29 per cent) had a revision or a resection of the prosthesis during the follow-up period. The revision or the resection was performed because of aseptic loosening in twenty-one hips (23 per cent), infection in four (4 per cent), dislocation in one (1 per cent), and fracture of the femur in one. Eighteen acetabular components (19 per cent) and five femoral components (5 per cent) were revised because of aseptic loosening, and an additional fourteen acetabular components (15 per cent) and seven femoral components (8 per cent) demonstrated definite or probable radiographic loosening. The present study demonstrates the long-term durability of total hip arthroplasty performed with cement in an active population of patients. The fixation of the femoral component was found to perform better than that of the acetabular component at twenty to twenty-five years after the procedure.     

浅谈黑客技术及其对策

本文通过对黑客起源及其文化的认识来分析黑客技术的发展,同时也针对当前一些主要的黑客攻击手段提出了防御的对策。     

Robust adaptive backstepping control for a class of uncertain nonlinear systems based on disturbance observers

In this paper, a novel robust adaptive control scheme for a class of uncertain nonlinear systems is proposed using disturbance observer and backstepping method.Firstly, a disturbance observer is developed using radial basis function(RBF) neural network.The parameter updated law of the RBF neural network is given for monitoring subsystem disturbance well.The robust adaptive control scheme is then presented with backstepping method based on the designed disturbance observer.Semiglobal uniform ultimate bounded...     

基于动力学分析的深海集矿机轨迹跟踪研究

分析深海集矿机轨迹跟踪的研究现状,研究集矿机的动力学模型,进行合理的简化,面向深海底采矿环境的特殊性、深海集矿机液压系统固有的强非线性、行走阻力随调节强度伴生变化等特征。基于非线性剪切力—位移关系的线性化方法和对动态阻力项引入一个前馈补偿项来消除伴生阻力方式,设计了一个基于带有前馈阻力补偿的线性反馈的控制器,较好地实现了集矿机轨迹跟踪;仿真结果验证了该算法的有效性。     

Biosynthesis of fatty acids from acetate in soybean suspension cultures

Suspension cultures of finely divided soybean cells established from callus were incubated with sodium [1(14)C] acetate for periods up to 86 hr. Lipids and fatty acids were analyzed for radioactivity in samples harvested at logarithmic time periods. Incorporation of acetate into cell lipid was directly proportional to the logarithm of time up to 32 hr, after an initial lag of 4-6 hr. Most of the lipid radioactivity was found in the phospholipid fraction, and all common soybean fatty acids became labeled within 6 hr. The order of labeling and distribution of radioactivity with time were essentially the same as in tissues from intact growing plants. These results support the concept of sequential desaturation of oleic acid in the cells. It was concluded that valid studies of the biosynthesis of common lipids in the soybean can be carried out for extended periods of time by use of undifferentiated cells in suspension cultures.     

基于3S技术的北京野鸭湖湿地资源的动态变化研究

充分利用现有的遥感影像资料,选取合适的算法对不同传感器和不同时相的遥感图像进行融合,得到清晰且分辨率高的融合图像,利用地理信息系统软件叠置分析功能并结合影像特征分析和野外调查,消除由于不同时相融合带来的不利影响。有效地提取出野鸭湖湿地1998年、2000年和2002年的湿地面积,并对其空间变化进行了对比分析。研究结果表明:由于近几年的持续干旱,野鸭湖湿地面积和空间位置发生了较大的变化。     

Book reviews

In many current semiconductor manufacturing operations, headcount is manually allocated periodically based on man-machine ratio. Attributed to non-optimised allocation of direct labour to operations/machines, considerable productivity loss occurs. The problem is further complicated by some dynamic and uncertain factors such as constantly changing production targets and work in progress, overlapped labour skills, and variability in manufacturing operations and labour absenteeism rates. Motivated by the needs in real practice, this study aims to develop a model for allocating a direct workforce among semiconductor manufacturing operations to meet production targets and maximise labour productivity. This paper presents a two-stage goal programming model for the headcount allocation problem. To enhance the model's pragmatic use, a queueing module is introduced to account for the interferences among the multi-machine operations. Computational experiments are carried out to evaluate the performances of the proposed algorithms and pilot runs are implemented in a factory. Finally, a prototype system is developed and has been proved to be useful in practice.