Analogue switch for very low-voltage applications

A new analogue switch suitable for operation at very low-voltage supply in a standard CMOS technology is presented. The proposed switch is based on 'quasi-floating-gate' transistors and has a simple and compact structure. For illustrative purposes, two sample-and-hold circuits operating from a single supply voltage close to the threshold voltage of a transistor, and using the proposed technique, are presented. Experimental results obtained from prototypes in a 1.5 /spl mu/m CMOS technology are provided.     

Analytical and numerical analysis of phase and amplitude errors in the performance of arrayed waveguide gratings

The closed expression of the mean power transfer function for an arrayed waveguide grating (AWG), taking into account fabrication errors, is presented. Comparison with numerical simulations using a previous Fourier optics modeling show good agreement. The procedure to predict the AWG floor level using the numerical modeling is presented and checked against the analytical derived expressions.     

Behavioral model synthesis with Cones

The Cones synthesis system for automatic generation of VLSI implementations is discussed. Named for the cones in sequential logic, Cones takes behavioral models written in C and produces gate-level implementations in technologies such as standard cells and programmable logic arrays or programmable logic devices. The overall design is produced faster, more efficiently, and with fewer errors. Designers are free to concentrate on functions, instead of on the details of the implementation technology     

A multiple-switch high-voltage DC-DC converter

Series connection of power devices has evolved into a mature technique and is widely applied in HV DC power systems. Static and dynamic voltage balance is ensured by shunting individual devices with dissipative snubbers. The snubber losses become pronounced for increased operating frequencies and adversely affect power density. Capacitive snubbers do not exhibit these disadvantages, but they require a zero-voltage switching mode. Super-resonant power converters facilitate the principle of zero-voltage switching. A high-voltage DC-DC power converter with multiple series-connected devices is proposed. It allows the application of nondissipating snubbers to assist the voltage sharing between the multiple series-connected devices and lowers turnoff losses. Simulation results obtained with a circuit simulator are validated in an experimental power converter operating with two series-connected devices. The behavior of the series connection is examined for MOSFETs and IGBTs by both experimental work with a 2 kW prototype and computer simulation. Applications can be found in traction and heavy industry, where the soft-switching power converter is directly powered from a high-voltage source     

The Effects of Insulin-Like Growth Factor I and BTP-2 on Acute Lung Injury

Acute lung injury (ALI) afflicts approximately 200,000 patients annually and has a 40% mortality rate. The COVID-19 pandemic has massively increased the rate of ALI incidence. The pathogenesis of ALI involves tissue damage from invading microbes and, in severe cases, the overexpression of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). This study aimed to develop a therapy to normalize the excess production of inflammatory cytokines and promote tissue repair in the lipopolysaccharide (LPS)-induced ALI. Based on our previous studies, we tested the insulin-like growth factor I (IGF-I) and BTP-2 therapies. IGF-I was selected, because we and others have shown that elevated inflammatory cytokines suppress the expression of growth hormone receptors in the liver, leading to a decrease in the circulating IGF-I. IGF-I is a growth factor that increases vascular protection, enhances tissue repair, and decreases pro-inflammatory cytokines. It is also required to produce anti-inflammatory 1,25-dihydroxyvitamin D. BTP-2, an inhibitor of cytosolic calcium, was used to suppress the LPS-induced increase in cytosolic calcium, which otherwise leads to an increase in proinflammatory cytokines. We showed that LPS increased the expression of the primary inflammatory mediators such as toll like receptor-4 (TLR-4), IL-1β, interleukin-17 (IL-17), TNF-α, and interferon-γ (IFN-γ), which were normalized by the IGF-I + BTP-2 dual therapy in the lungs, along with improved vascular gene expression markers. The histologic lung injury score was markedly elevated by LPS and reduced to normal by the combination therapy. In conclusion, the LPS-induced increases in inflammatory cytokines, vascular injuries, and lung injuries were all improved by IGF-I + BTP-2 combination therapy.     

In Vitro Characterization of Human CD24hiCD38hi Regulatory B Cells Shows CD9 Is Not a Stable Breg Cell Marker

Regulatory B (Breg) cells are endowed with immune suppressive functions. Various human and murine Breg subtypes have been reported. While interleukin (IL)-10 intracellular staining remains the most reliable way to identify Breg cells, this technique hinders further essential functional studies. Recent findings suggest that CD9 is an effective surface marker of murine IL-10 competent Breg cells. However, the stability of CD9 and its relevance as a unique marker for human Breg cells, which have been widely characterized as CD24^hiCD38^hi, have not been investigated. Here, we demonstrate that CD9 expression is sensitive to in vitro B cell stimulations. CD9 expression could either be re-expressed or downregulated in purified CD9-negative B cells and CD9-positive B cells, respectively. We found no significant differences in the Breg differentiation capacity of the CD9-negative and CD9-positive B cells. Furthermore, CD9-positive B cells co-express CD40 and CD86, suggesting their nature as B cell activation or co-stimulatory molecules, rather than regulatory ones. Therefore, we report the relatively unstable CD9 as a distinct surface molecule, indicating the need for further research for a more reliable marker to purify human Breg cells.     

Lyapunov-Based Model Predictive Control of Nonlinear Systems Subject to Data Losses

In this work, we focus on model predictive control of nonlinear systems subject to data losses. The motivation for considering this problem is provided by wireless networked control systems and control of nonlinear systems under asynchronous measurement sampling. In order to regulate the state of the system towards an equilibrium point while minimizing a given performance index, we propose a Lyapunov-based model predictive controller which is designed taking data losses explicitly into account, both in the optimization problem formulation and in the controller implementation. The proposed controller allows for an explicit characterization of the stability region and guarantees that this region is an invariant set for the closed-loop system under data losses, if the maximum time in which the loop is open is shorter than a given constant that depends on the parameters of the system and the Lyapunov-based controller that is used to formulate the optimization problem. The theoretical results are demonstrated through a chemical process example.     

Aligned texture map creation for pose invariant face recognition

In last years, Face recognition based on 3D techniques is an emergent technology which has demonstrated better results than conventional 2D approaches. Using texture (180° multi-view image) and depth maps is supposed to increase the robustness towards the two main challenges in Face Recognition: Pose and illumination. Nevertheless, 3D data should be acquired under highly controlled conditions and in most cases depends on the collaboration of the subject to be recognized. Thus, in applications such as surveillance or control access points, this kind of 3D data may not be available during the recognition process. This leads to a new paradigm using some mixed 2D-3D face recognition systems where 3D data is used in the training but either 2D or 3D information can be used in the recognition depending on the scenario. Following this concept, where only part of the information (partial concept) is used in the recognition, a novel method is presented in this work. This has been called Partial Principal Component Analysis (P²CA) since they fuse the Partial concept with the fundamentals of the well known PCA algorithm. This strategy has been proven to be very robust in pose variation scenarios showing that the 3D training process retains all the spatial information of the face while the 2D picture effectively recovers the face information from the available data. Furthermore, in this work, a novel approach for the automatic creation of 180° aligned cylindrical projected face images using nine different views is presented. These face images are created by using a cylindrical approximation for the real object surface. The alignment is done by applying first a global 2D affine transformation of the image, and afterward a local transformation of the desired face features using a triangle mesh. This local alignment allows a closer look to the feature properties and not the differences. Finally, these aligned face images are used for training a pose invariant face recognition approach (P²CA).