Fast Positive Feedback Between the Adrenocortical Stress Response and a Brain Mechanism Involved in Aggressive Behavior.

Aggressive behavior induces an adrenocortical stress response, and sudden stressors often precipitate violent behavior. Experiments in rats revealed a fast, mutual, positive feedback between the adrenocortical stress response and a brain mechanism controlling aggression. Stimulation of the aggressive area in the hypothalamus rapidly activated the adrenocortical response, even in the absence of an opponent and fighting. Hypothalamic aggression, in turn, was rapidly facilitated by a corticosterone injection in rats in which the natural adrenocortical stress response was prevented by adrenalectomy. The rapidity of both effects points to a fast, mutual, positive feedback of the controlling mechanisms within the time frame of a single conflict. Such a mutual facilitation may contribute to the precipitation and escalation of violent behavior under stressful conditions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

电容式触摸传感器提升应用设计

好像在突然之间，电容式传感器就无处不在了。它被安装在汽车座位里以控制气囊配置和安全带预紧装置，在洗碗机和干燥机中以校正旋转桶的状态，甚至冰箱也使用其来控制自动去冰过程。但是直到现在，它最大的潜在应用领域还是触摸开关，触摸开关已越来越多地出现在消费电子产品中。     

SH3 binding domains in the dopamine D4 receptor

The dopamine D4 receptor is a G protein-coupled receptor (GPCR) that belongs to the dopamine D2-like receptor family. Functionally, the D2-like receptors are characterized by their ability to inhibit adenylyl cyclase. The dopamine D4 receptor as well as many other catecholaminergic receptors contain several putative SH3 binding domains. Most of these sites in the D4 receptor are located in a polymorphic repeat sequence and flanking sequences in the third intracellular loop. Here we demonstrate that this region of the D4 receptor can interact with a large variety of SH3 domains of different origin. The strongest interactions were seen with the SH2-SH3 adapter proteins Grb2 and Nck. The repeat sequence itself is not essential in this interaction. The data presented indicate that the different SH3 domains in the adapter proteins interact in a cooperative fashion with two distinct sites immediately upstream and downstream from the repeat sequence. Removal of all the putative SH3 binding domains in the third intracellular loop of the dopamine D4 receptor resulted in a receptor that could still bind spiperone and dopamine. Dopamine could not modulate the coupling of these mutant receptors to adenylyl cyclase and MAPK, although dopamine modulated receptor-G protein interaction appeared normal. The receptor deletion mutants show strong constitutive internalization that may account for the deficiency in functional activation of second messengers. The data indicates that the D4 receptor contains SH3 binding sites and that these sites fall within a region involved in the control of receptor internalization.     

Difficult to Let Housing Association Stock in England: Property,Management and Context

Problems related to unpopular housing are not new in Britain's social rented sector. In the past, however, these have generally been associated with housing provided directly by the state through local authorities. For many, the term 'difficult to let' has become synonymous with large, ageing, poor quality estates managed under a centralised framework and subject to a long period of low investment and indifferent management. There has also been a long-standing assumption that social housing allocations systems tend to channel the most vulnerable tenants into the least desirable housing. In fact, the problem of difficult to let property is now as pervasive in the not-for-profit sector managed by housing associations as it is within council housing. In many cases the developments affected are small in scale and, in a significant proportion of cases, recently constructed. In explaining why property becomes difficult to let, the local and regional context is clearly important. The balance between social, economic and housing demand circumstances and property and estate characteristics varies between regions. There is relatively little evidence that difficult to let housing association properties are occupied by disproportionate numbers of the most severely disadvantaged tenants and this suggests that something has happened to modify the segregating effects of allocations systems observed in earlier studies. Nevertheless, this apparent change must be seen within the context of the general trend towards a residual role for social housing in its entirety. The social class and income range of new social sector tenants now is much diminished by comparison with earlier decades with few distinctions between the occupiers of difficult to let and other housing.     

ZXJ10机IN业务功能扩展及实现

本文从智能网的基本概念入手,论述了利用 ZXJ10程控交换系统为发展智能网业务提供支持功能的技术策略以及分阶段实现的过程,并对各个阶段能够实现的业务作了简要介绍。     

A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain

The Shc adaptor protein, hereafter referred to as ShcA, possesses two distinct phosphotyrosine-recognition modules, a C-terminal Src homology 2 (SH2) domain and an N-terminal phosphotyrosine-binding (PTB) domain, and is itself phosphorylated on tyrosine in response to many extracellular signals. Phosphorylation of human ShcA at Tyr-317 within its central (CH1) region induces binding to the Grb2 SH2 domain and is thereby implicated in activation of the Ras pathway. Two shc-related genes (shcB and shcC) have been identified in the mouse. shcB is closely related to human SCK, while shcC has not yet been found in other organisms. The ShcC protein is predicted to have a C-terminal SH2 domain, a CH1 region with a putative Grb2-binding site, and an N-terminal PTB domain. The ShcC and ShcB SH2 domains bind phosphotyrosine-containing peptides and receptors with a specificity related to, but distinct from, that of the ShcA SH2 domain. The ShcC PTB domain specifically associates in vitro with the autophosphorylated receptors for nerve growth factor and epidermal growth factor. These results indicate that ShcC has functional SH2 and PTB; domains. In contrast to shcA, which is widely expressed, shcC RNA and proteins are predominantly expressed in the adult brain. These results suggest that ShcC may mediate signaling from tyrosine kinases in the nervous system, such as receptors for neurotrophins.     

Measurement of Adhesive Bond Properties Including Damage by Dynamic Mechanical Thermal Analysis of a Beam Specimen

A method to obtain mechanical properties using a bonded (double) cantilever beam (or three point bend) specimen loaded in a manner to produce pure shear in the adhesive layer is reviewed. A revised mathematical solution which allows for easier interpretation of optimum beam dimensions to the one originally developed by Moussiaux, Cardon and Brinson for the static case is presented. An extension of this solution for a fixed/fixed viscoelastic beam under steady state oscillations developed by Li, Dickie and Morman is also discussed. Previous results using a vibrating beam to determine the complex viscoelastic properties of a bonded beam are reviewed. These results demonstrate conclusively that dynamic mechanical thermal analysis (DMTA) measurements discriminate differences in surface treatments and various environmental conditions. New measurements are presented that indicate the DMTA procedure can be used to quantify damage simulated by imbedded flaws in beams. The procedure is also shown to assess the effects of both humidity and corrosive environments on lap specimens. It is suggested that this technique may ultimately provide a method to quantify the amount of hidden damage in an adhesive joint subjected to fatigue, moisture or corrosive environments.     

氧化作用控制“四硫富瓦烯-葸”二元体系的荧光开关行为

利用Wittig反应将高荧光量子产率的蒽基团通过双键连接在四硫富瓦烯单元上，合成了二元共轭体系化合物TTFan．在氧化作用的控制下，四硫富瓦烯单元的给电子能力降低，TTFan的荧光发射强度增大至原来的十几倍，实现了荧光的“off-on”过程．