室内机组的开发与应用

随着市场的发展,精品超市和改造店铺逐渐增多,需要一种更加适合的制冷机组来满足市场的需求。本文提供了一种新型的解决方案,解决了现有机组存在的高噪音和高成本问题,不仅提高了制冷效率,而且节约能源,保护环境。     

A computer aided design method for car form and its application based on shape parameters

In the early design stage, automotive modeling should both meet the requirements of aesthetics and engineering. Therefore, a vehicle CAD (computer aided design) model that can be easily adjusted by feedbacks is necessary. Based on CE-Bézier surface, this paper presents a set of algorithms for parametric segmentation and fairing surface generation in a car model. This model is defined by a simplified automotive template and relevant control points, shape parameters and segmentation parameters, which can be modified to alter the car form efficiently. With this model and the corresponding adjustment method, more than fifty various vehicle models are established in this research according to different parameters. And two methods for calculating similarity index between car models are constructed, which are suitable for brand design trend analysis and modelling design decisionmaking.     

Discovery of Affinity-Based Probes for Btk Occupancy Assays

Bruton's tyrosine kinase (Btk) is an attractive target for the treatment of a wide array of B-cell malignancies and autoimmune diseases. Small-molecule covalent irreversible Btk inhibitors targeting Cys481 have been developed for the treatment of such diseases. In clinical trials, probe molecules are required in occupancy studies to measure the level of engagement of the protein by these covalent irreversible inhibitors. The result of this pharmacodynamic (PD) activity provides guidance for appropriate dosage selection to optimize inhibition of the drug target and correlation of target inhibition with disease treatment efficacy. This information is crucial for successful evaluation of drug candidates in clinical trials. Based on the pyridine carboxamide scaffold of a novel solvent-accessible pocket (SAP) series of covalent irreversible Btk inhibitors, we successfully developed a potent and selective affinity-based biotinylated probe 12 (2-[(4-{4-[5-(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)pentanoyl]piperazine-1-carbonyl}phenyl)amino]-6-[1-(prop-2-enoyl)piperidin-4-yl]pyridine-3-carboxamide). Compound 12 has been used in Btk occupancy assays for preclinical studies to determine the therapeutic efficacy of Btk inhibition in two mouse lupus models driven by TLR7 activation and type I interferon.     

红枣多糖提取、分离纯化及生物活性研究进展

红枣作为我国传统的药食同源的天然保健果品,已有近四千多年的栽植和食用历史。红枣多糖是一种复合杂多糖,现代药理学研究表明多糖是红枣果中主要的功能活性成分之一,具有抗氧化、抗肿瘤、免疫保肝及调节肠道菌群等功能。本文系统地综述了国内外近年来关于红枣多糖提取、分离纯化、结构特征及生物活性的研究进展,以期为提高红枣多糖的利用以及为进一步深入研究红枣多糖构效关系提供理论依据。     

服装新产品市场测试进展

在综合分析研究现状的基础上，以国内的服装行业为研究背景，探讨服装新产品的市场测试方案，文中提出一种基于商店聚类分析的测试方法.     

三峡三期工程大坝混凝土内部温度控制

三峡右岸三期工程施工中,为了有效控制坝体混凝土内部温升,采取了预冷混凝土浇筑、控制混凝土出机口温度及入仓温度,对混凝土内部通水初冷、中冷和后冷等措施,大坝混凝土内部温度没有出现超标现象,混凝土温控工作取得了良好的效果。     

Ru的添加量对FeMn尖晶石的结构 及其氧化性能的影响

 考察了随着FeMn尖晶石催化剂中Ru的添加量的变化以及助剂Cu的加入，催化剂物理结构及化学性质的变化。结果表明，Cu的添加不仅对催化剂的比表面和孔径分布有较大的影响，还对各元素的化学环境有较大的影响。当n(Ru)/n(Mn)为0.05时，由于尚未破坏尖晶石的结构，Ru的存在对于催化剂中其它元素如Mn、Fe和O的化学环境具有较大的影响，当n(Ru)/n(Mn)大于0.15时，尖晶石结构被破坏，Ru含量的增加对于其它元素如Mn、Fe和O的化学环境影响不大，对于比表面积和孔径分布等物理性质也影响很小。所研究的催化剂均可催化氧化醇至醛或酮，Ru的含量越大，催化醇液相氧化性能越好。