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排序方式: 共有419条查询结果,搜索用时 15 毫秒
1.
Napoli Maria Lia Barbero Monica Scavia Claudio 《Bulletin of Engineering Geology and the Environment》2021,80(10):7457-7466
Bulletin of Engineering Geology and the Environment - A wide range of heterogeneous geological units composed of strong rock blocks enclosed in a bonded matrix of fine texture exists worldwide.... 相似文献
2.
JP Antel E McCrea U Ladiwala YF Qin B Becher 《Canadian Metallurgical Quarterly》1998,160(4):1606-1611
Oligodendrocytes and their myelin membranes are the apparent target of the autoimmune response that characterizes the human adult central nervous system-demyelinating disease multiple sclerosis. Human oligodendrocytes do not express MHC class II molecules, a requirement for MHC-restricted injury mediated by myelin-reactive CD4+ T cells, the cell type implicated in initiating the disease process. In this study we observed that human adult central nervous system-derived oligodendrocytes can be susceptible to non-MHC-restricted lysis mediated by myelin basic protein-reactive CD4+ T cell lines. Cytotoxicity was significantly greater (37 +/- 4 vs 7 +/- 3%) with cell lines in which a high proportion of cells (mean, 28 +/- 6%) expressed CD56 compared with cytotoxicity mediated by low CD56 cell lines (8 +/- 2%). High CD56 cell lines, when rested in IL-2, lost cytotoxic activity and had reduced expression of CD56 (mean, 5 +/- 2%). CD4+ T cells isolated from short term (3-day) anti-CD3/IL-2-activated mononuclear cell cultures did not express CD56 and were not cytotoxic to oligodendrocytes unless lectin was added. In contrast, an enriched population of non-T cells extracted from the same activated MNC cultures expressed CD56 as well as other NK cell-associated surface molecules and was cytotoxic. These results indicate the potential susceptibility of human oligodendrocytes to non-MHC-restricted injury mediated by both Ag-reactive and nonspecific cellular immune effector cells, with CD56 expression being a common feature of the effector cells. 相似文献
3.
Paul F. Becher 《Journal of Materials Science》1986,21(1):297-300
The room temperature slow crack growth resistance in air ( 50% relative humidity) and in water for large cracks in MgO-partially stabilized zircoba (PSZ) improves with increase in critical fracture toughness,K
lc. Ageing the as-fired PSZ at 1400° C for 8 h results in decreasing Klc from 8.5 MPa m1/2 to 6 M Pa M1/2. The ageing treatment also promotes the growth of eutectoid decomposition products on grain boundaries that is accompanied by a decrease in the dependence (A the change in Region I crack velocity with a change in the applied stress intensity. Calculated times to failures are markedly decreased in the aged as compared to the as-fired PSZ ceramic. 相似文献
4.
5.
The adherence of a glass bonded Pt-Au thick film conductor to various alumina substrates is degraded by changes in the surface
composition of and by the presence of (0001) crystallographic texture in the substrate. Using the critical fracture energy
(γIC) required to separate the thick film from the substrate, it was found that γIC was reduced from a maximum of 3.7 J m−2 using an as-received 96+ wt% alumina substrate to ∼2J m−2 using an as-received 99+ wt% alumina. In addition, the thick film adherence γIC using (0001) sapphire substrates was less than that using (11ˉ23) sapphire. The 96 wt% substate exhibited essentially a random
crystallographic surface texture and a considerable amount of surface silicates. The as-received 99+ wt% Al2O3 substrate was charactarized by a high (0001) surface texture and, while exhibiting a similar composition silicate layer as
that of the as-received 96 wt% alumina, the total amount of the glass layer is greatly diminished. Fractographic analysis
of the separated thick films and substrates showed that changes in the substrate crystallographic texture and the glass layer
diminish the interpenetrating nature of the glass—metal interface and weaken the glass—substrate interface. Such changes in
thick film microstructure lead to poorer thick film adherence. 相似文献
6.
Felice Strollo Lia Pecorelli Giovanna Strollo Massimo Morè Giuseppe Riondino Maria Angela Masini Bianca Maria Uva 《Microgravity science and technology》2006,18(3-4):226-229
A significant reversible decrease in testosterone (T) has been associated with microgravity in male rodents and humans. Urinary T excretion increases in primates under hypergravity. Hypogonadism is somehow related to abnormally high levels of leptin (L), a hormone produced by the adipose tissue which has been found to increase under microgravity simulation conditions like head down bed rest (HDBR). The aim of this study was to assess hemodynamic and pituitary-adrenal and -gonadal adaptation to an acute HDBR test to be eventually used on a routine basis to get better prepared to next space flights. The Authors performed a 1 hour ?12° HDBR in 6 male and 6 female volunteers who underwent heart rate and blood pressure measurement together with a blood draw three times at 30 min intervals from the start to the end of the test for L, T, estradiol (E2), LH, androstenedione (A), cortisol (F), ACTH. 12 age- and sexmatched control subjects followed the same protocol except for keeping the sitting position all the time. According to the ANOVA for repeated measures, no changes occurred in L, T, E2 or LH whereas A, F and ACTH significantly decreased independently of gender. During HDBR systolic blood pressure decreased in both genders, diastolic blood pressure decreased significantly only in men and HR showed a more clear-cut decrease in women than in men. As a conclusion, such an acute steep-slope HDBR protocol may be efficiently used to testing immediate individual haemodynamic or adrenal response to microgravity but is not suitable for studies concerning gonadal adaptation. 相似文献
7.
对收集到的7种国内外铜带轧制润滑剂进行了基础性能测试,并对其工艺使用性能进行了评价研究,其结果将为有关工厂润滑剂的选用与研制提供一些依据。 相似文献
8.
Lia Toledo Moreira Mota Alexandre Assis Mota 《International Journal of Electrical Power & Energy Systems》2004,26(10):805-811
This paper is focused on electric power distribution substations load modeling using dynamic load parameters estimation. The load parameters are estimated using two models: the exponential and the ZIP load models. Since the load bus voltage and parameters are known one can determine the active and reactive power injections of this bus and include these pseudo-measurements in the state estimation in order to improve observability and estimation accuracy. The dynamic parameter estimation is developed using the weighted least squares method in a recursive form and the tests are carried out based on actual measurements. It is shown that the estimated parameters (for both load models) at a distribution substation are valid, since the obtained active and reactive power residuals are very close to zero. 相似文献
9.
Thomsen C Knutsen HK Liane VH Frøshaug M Kvalem HE Haugen M Meltzer HM Alexander J Becher G 《Molecular nutrition & food research》2008,52(2):228-237
Very high concentrations of polybrominated diphenyl ethers (PBDE) have been reported in fish from Lake Mj?sa in Norway. This study was performed to examine the serum concentrations of PBDE and hexabromocyclododecane (HBCD) in consumers of fish from this lake and to investigate possible relationships between serum concentrations, self-reported fish intake and calculated total dietary PBDE exposure. Serum concentrations of the sum of the seven PBDE (BDE-28, 47, 99, 100, 153, 154 and 183) were significantly higher than those of a reference group of Norwegians eating only food with background levels of contamination (medians: 18 ng/g lipids men, 8.4 ng/g lipids women). The median dietary intake of Sum 7 PBDE was 2549 ng/day (30 ng/kg body weight/day), the highest dietary intake of PBDE reported. The contribution from fish caught from the contaminated lake comprised 98.7% of the total dietary exposure. For men, serum levels of PBDE were strongly correlated with the calculated dietary exposure, except for BDE-209. This suggests that sources other than the diet are important for human BDE-209 exposure. The median serum HBCD concentration was 4.1 and 2.6 ng/g lipids for men and women, respectively, and was also found to be associated with consumption of fish from Lake Mj?sa. 相似文献
10.
A direct carbon fuel cell (DCFC) is a variation of the molten carbonate fuel cell (MCFC) which converts the chemical energy of carbon directly into electrical energy. Thus, the energy conversion efficiency is very high and correspondingly CO2 emission is very low for given power output. DCFC as a high temperature fuel cell performs better at elevated temperatures (>800 °C) but because of the corrosive nature of the molten carbonates at elevated temperatures the degradation of cell components becomes an issue when DCFC is operated for an extended period of time.We explored the DCFC performance at lower temperatures (at 700 °C and less) using different sources of carbon, different compositions of electrolytes and some additives on the cathode surface to increase catalytic activity. Experiments showed that with petroleum coke as a fuel at low temperatures the ternary eutectic (43.4 mol % Li2CO3 - 31.2 mol% Na2CO3 - 25.4 mol % K2CO3) spiked by 20 wt % Cs2CO3 performed better than any binary or ternary eutectics described in the published work by other researchers. Maximum power output achieved at 700 °C was 49 mW/cm2 at a current density of 78 mA/cm2 when modified cathode was fed with O2/CO2 gases. 相似文献