Enzymatic Synthesis of Glucose- and Xylose Laurate Esters Using Different Acyl Donors,Higher Substrate Concentrations,and Membrane Assisted Solvent Recovery

Glucose- and xylose laurate esters are enzymatically synthesized using equimolar substrate concentrations in 2-methyl-2-butanol, comparing free lauric acid with methyl- and vinyl-laurate as acyl donors. All reactions result in ≥70% acyl donor conversions after 72 h but the activated donors are also partially hydrolyzed to lauric acid, highlighting the difficulty in controlling water presence in this particular reaction system. The esterification of xylose generates a complex product profile, with several regioisomers of monoesters and diesters. The esterification of glucose is quite selective, forming mainly the 6-O monoester (≥96%) with a small presence of two diester isomers (4%). Increasing substrate concentration up to 800 millimoles kg⁻¹ results in lower conversion values (down to 58%) but shows that the reaction proceeds successfully even in the presence of high amounts of insoluble glucose. However, the reaction is less selective and the proportion of diester increases, becoming up to 46% (molar fraction) of the final product. Solvent recovery after esterification can be achieved by organic solvent nanofiltration through a polymeric membrane able to retain ≥80% of all reaction substrates and products. Practical Applications: The use of high substrate concentrations during the enzymatic synthesis of sugar ester biosurfactants leads to product titers that are more industrially appealing, without the need to find a solvent that can solubilize all initial substrate. The sustainability of the enzymatic conversion at mild temperatures can be enhanced by recycling of the reaction solvent through organic solvent nanofiltration, an energy efficient alternative to other traditional methods like distillation.     

Where's My Jetpack?

Software development tools often fail to deliver on inflated promises. Rather than the predicted progression toward ever-increasing levels of abstraction, two simple trends have driven the evolution of currently available software development tools: integration at the source-code level and a focus on quality. Thus source code has become the bus that tools tap into for communicating with other tools. Also, focus has shifted from defect removal in the later phases to defect prevention in the earlier phases. In the future, tools are likely to support higher levels of abstraction, perhaps in the form of domain-specific languages communicated using XML.     

Pragmatic software tools for water reuse evaluation in a factory

The optimal use of process water becomes increasingly important since natural water resources are heavily solicited by a growing economy. Two steps can be considered in the process water optimization. A first step is the inventory of the different process streams in the process water network. Pure mathematical modeling of a dynamic water network is extremely complicated and expensive. As an approximation, the use of a steady-state network node model within commercial software is accepted to set up a water balance. Sophisticated software tools are available but common solver software may offer an alternative. A second step is the water “pinch” which searches for an optimal use of process water by combining sources and sinks, taking into account contaminant concentrations of process streams. Sophisticated pinch software can be applied but it is also possible to implement a simplified combinatory approach. Such approach can be pragmatically programmed in e.g., Visual Basic. Such tool allows for a first evaluation of the complex combinatory sources–sinks problem, enabling a low cost and easy-to-handle first interpretation of possible water-reuse opportunities. This could stimulate a further enhanced analysis with more advanced software tools and therefore promote a sustainable use of process water in the industrialized world.     

Influence of massive heat-pump introduction on the electricity-generation mix and the GHG effect: Comparison between Belgium, France, Germany and The Netherlands

To evaluate the environmental impact of massive heat-pump introduction on greenhouse gas (GHG) emissions in different electricity-generation systems, dynamic simulations have been carried out for four European countries, namely, Belgium, France, Germany and the Netherlands. For this purpose, the simulations are performed with Promix, a tool that models the overall electricity-generation system. Three heating devices are considered for each country, namely classic fossil-fuel heating, heat pumps and electric resistance heating. Both direct heat-pump heating with a coefficient of performance (COP) of 2.5 and accumulation heat-pump heating with a COP of 5 are investigated. The introduction of electric heating in an electricity-generation system increases the demand for electricity and generates a shift of emissions from fossil-fuel heating systems to electrical plants. The results of the simulations reveal that the massive introduction of either heat pump or resistance heating is always favourable to the environment in France. The most environmentally friendly scenario in 2010 is projected to reduce GHG emissions by about 3.8 Mton compared to the reference scenario. In Belgium and Germany, the largest reduction in GHG emissions occurs with accumulation heat pumps. Belgium can save up to 220 kton of GHG emissions, while Germany can attain reductions of 800 kton in 2010. In the Netherlands, a significant reduction can be achieved by considering the addition of gas-fired combined cycle (CC) power plants, together with the introduction of electric heating, resulting in emissions savings of 410 kton.     

Simplifications for hydronic system models in modelica

Building systems and their heating, ventilation and air conditioning flow networks, are becoming increasingly complex. Some building energy simulation tools simulate these flow networks using pressure drop equations. These flow network models typically generate coupled algebraic nonlinear systems of equations, which become increasingly more difficult to solve as their sizes increase. This leads to longer computation times and can cause the solver to fail. These problems also arise when using the equation-based modelling language Modelica and Annex 60-based libraries. This may limit the applicability of the library to relatively small problems unless problems are restructured. This paper discusses two algebraic loop types and presents an approach that decouples algebraic loops into smaller parts, or removes them completely. The approach is applied to a case study model where an algebraic loop of 86 iteration variables is decoupled into smaller parts with a maximum of five iteration variables.     

Polycyclic N-benzamido imides with potent activity against vaccinia virus

The synthesis and antiviral activity of a series of novel polycyclic analogues of the orthopoxvirus egress inhibitor tecovirimat (ST‐246) is presented. Several of these compounds display sub‐micromolar activity against vaccinia virus, and were more potent than cidofovir (CDV). The more active compounds were about 10‐fold more active than CDV, with minimum cytotoxic concentrations above 100 μM . Chemical manipulations of the two carbon–carbon double bonds present in the compounds were carried out to further explore the structure–activity relationships of these new polycyclic imides. Hydrogenation of the two carbon–carbon double bonds decreases antiviral activity, whereas either cyclopropanation or epoxidation of the double bonds fully eliminates the antiviral activity.     

Aging and the negative priming effect: A meta-analysis.

This article reports results from a meta-analysis on adult age differences in the negative priming effect (21 studies on identity negative priming and 8 on location negative priming). Both younger and older adults were found to be susceptible to the negative priming effect in identity and location tasks. Effect sizes were homogeneous for both tasks, indicating that the data are adequately described without reference to moderator variables. State trace analysis on identity tasks, in which mean latencies in negative priming conditions were regressed onto mean latencies in baseline conditions, showed (a) that in both age groups the negative priming effect is proportional rather than additive and (b) that the negative priming effect is smaller in older adults as compared with younger adults. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Aging and the Stroop effect: A meta-analysis.

In this meta-analysis, data from 20 studies comparing younger and older adults on the Stroop interference effect, contained in 15 articles, were analyzed. No significant difference was found in the Stroop interference effect, expressed as mean standardized difference, between the 2 age groups (for younger adults: d?=?2.04; for older adults: d?=?2.17). Moderator variables were present, but these did not produce age differences. Brinley analysis showed that a single regression line with a slowing factor of 1.9 described the data well (R2?=?.83) and confirmed that no Age?×?Condition interaction was present in the data. Likewise, no Age?×?Condition interaction was found when the data were fitted to the information loss model; the age ratio of decay rates was estimated to be 1.4. Consequently, the apparent age-sensitivity of the Stroop interference effect appears to be merely an artifact of general slowing. (PsycINFO Database Record (c) 2010 APA, all rights reserved)