Simultaneous electrolytic production of xylitol and xylonic acid from xylose

A new electrocatalytic process for simultaneous electrolytic production of xylitol and xylonic acid or the corresponding xylonate salts directly from -d-xylose in alkaline solutions of neutral salt as supporting electrolyte has been developed and presented. An electrocatalytically active cathode coating with essentially hydridic features has been employed to enhance Faradaic yields in xylitol production at low current densities by heterogeneous reaction of hydrogenation with H-adatoms, and the entire mechanism has been proved by experimental evidence. An anionic selective anodic coating for titanium substrate was also used to suppress oxygen evolution and optimize the xylonic acid production by direct oxidation with anodically generated bromine, and to carry out the electrode process at almost equilibrium potential. The kinetic effect of specifically adsorbable anions for decreasing cathodic current yields in xylitol production and the resulting necessity for membrane separation of catholyte from anolyte, with proper optimization of the supporting neutral salt composition, has also been emphasized.Paper partly presented at 39th and 40th ISE-Meetings at Glasgow UK, 1988 and Kyoto, Japan, 1989.     

Extending the power of datalog recursion

Supporting aggregates in recursive logic rules represents a very important problem for Datalog. To solve this problem, we propose a simple extension, called Datalog $^{FS}\,$ (Datalog extended with frequency support goals), that supports queries and reasoning about the number of distinct variable assignments satisfying given goals, or conjunctions of goals, in rules. This monotonic extension greatly enhances the power of Datalog, while preserving (i) its declarative semantics and  (ii) its amenability to efficient implementation via differential fixpoint and other optimization techniques presented in the paper. Thus, Datalog $^{FS}\,$ enables the efficient formulation of queries that could not be expressed efficiently or could not be expressed at all in Datalog with stratified negation and aggregates. In fact, using a generalized notion of multiplicity called frequency, we show that diffusion models and page rank computations can be easily expressed and efficiently implemented using Datalog $^{FS}\,$ .     

Triple-product optical processor for analysis of pulse-repetition and carrier frequencies of radar signals

A triple-product acousto-optic processor output was studied analytically and numerically. The processor is capable of detecting the carrier frequency and the modulation envelope of a signal.     

Serum from diabetic BB/W rats enhances calcium currents in primary sensory neurons

We examined the hypothesis that exposure of nondiabetic rat dorsal root ganglion (DRG) neurons to sera from diabetic BB/W rats would produce an increase in calcium currents associated with impaired regulation of the inhibitory G protein-calcium channel complex. Acutely dissociated rat DRGs were incubated for 18-24 h in medium supplemented with sera (10% vol/vol) from either diabetic rats with neuropathy or age-matched, nondiabetic controls. Exposure of DRG neurons to sera from diabetic BB/W rats resulted in a surface membrane immunofluorescence pattern when treated with an anti-rat light-chain antibody that was not observed in neurons exposed to control sera. Calcium current density (IDCa) was assessed with the use of the whole cell variation of the patch-clamp technique. IDCa in neurons exposed to diabetic sera was significantly increased compared with neurons exposed to control sera. Guanine nucleotide-binding (G) protein regulation of calcium channel function was examined with the use of a two-pulse "facilitation" or IDCa enhancement protocol in the presence of activators [guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S)] or antagonists [guanosine 5'-O-(2-thiodiphosphate) (GDP beta S) and pertussis toxin (PTX)] of G protein function. Facilitation was significantly decreased in neurons exposed to diabetic sera. Intracellular diffusion of neurons with GDP beta s blocked facilitation, whereas dialysis with GTP gamma s increased facilitation to a similar magnitude in neurons exposed to either diabetic or control sera. Treatment with PTX resulted in a significant increase in IDCa and approximately 50% decrease in facilitation in neurons treated with control sera but no significant changes in neurons exposed to diabetic sera. We conclude that serum from diabetic BB/W rats with neuropathy contains an autoimmune immunoglobulin that impairs regulation of the inhibitory G protein-calcium channel complex, resulting in enhanced calcium influx. Regulation of the inhibitory G protein-calcium channel complex involves PTX-sensitive and -insensitive G proteins.     

CAD based shape optimization for gas turbine component design

In order to improve product characteristics, engineering design makes increasing use of Robust Design and Multidisciplinary Design Optimisation. Common to both methodologies is the need to vary the object’s shape and to assess the resulting change in performance, both executed within an automatic loop. This shape change can be realised by modifying the parameter values of a suitably parameterised Computer Aided Design (CAD) model. This paper presents the adopted methodology and the achieved results when performing optimisation of a gas turbine disk. Our approach to hierarchical modelling employing design tables is presented, with methods to ensure satisfactory geometry variation by commercial CAD systems. The conducted studies included stochastic and probabilistic design optimisation. To solve the multi-objective optimisation problem, a Pareto optimum criterion was used. The results demonstrate that CAD centric approach enables significant progress towards automating the entire process while achieving a higher quality product with the reduced susceptibility to manufacturing imperfections.     

Coupling AFM,DSC and FT-IR towards Elucidation of Film-Forming Systems Transformation to Dermal Films: A Betamethasone Dipropionate Case Study

Polymeric film-forming systems have emerged as an esthetically acceptable option for targeted, less frequent and controlled dermal drug delivery. However, their dynamic nature (rapid evaporation of solvents leading to the formation of thin films) presents a true characterization challenge. In this study, we tested a tiered characterization approach, leading to more efficient definition of the quality target product profiles of film-forming systems. After assessing a number of physico-chemico-mechanical properties, thermal, spectroscopic and microscopic techniques were introduced. Final confirmation of betamethasone dipropionate-loaded FFS biopharmaceutical properties was sought via an in vitro skin permeation study. A number of applied characterization methods showed complementarity. The sample based on a combination of hydrophobic Eudragit^® RS PO and hydroxypropyl cellulose showed higher viscosity (47.17 ± 3.06 mPa·s) and film thickness, resulting in sustained skin permeation (permeation rate of 0.348 ± 0.157 ng/cm² h), and even the pH of the sample with Eudragit^® NE 30D, along with higher surface roughness and thermal analysis, implied its immediate delivery through the epidermal membrane. Therefore, this study revealed the utility of several methods able to refine the number of needed tests within the final product profile.     

Review of the economic viability of investing and exploiting biogas electricity plant - Case study Vizelj, Serbia

Construction and operation of plants that produce energy from renewable energy sources is the subject for discussion in all the countries that have accepted the sustainable development concept and Kyoto protocol as their own development direction. Enlargement of the renewable energy production is clearly an imperative, but only economically viable construction and operation can result in long-term sustainability, which is initially the goal when deciding upon such investments. In line with this goal, this paper presents the estimation of the economic viability of constructing and operating biogas electricity plant on the farm Vizelj in Serbia. The timeframe for this estimation is from 2011 until 2020. This paper also presents all parameters which are necessary for performing this estimation, respectively, analysis of revenues and expenditures, projection of economic and financial flow, ratio analysis, dynamic and static analysis, and analysis of sensitivity of the project, i.e. impact of the changes in prices and raw material on the overall performance of the project. The observed investment is predicted to be financed from the EBRD's credit line for renewable energy in Western Balkans, while the total investment is estimated at Euro 958,000.00. After the performed economic assessment, the conclusion is that the observed investment in biogas electricity plant is very acceptable and it can serve as a role model for similar investments in the region.     

Galectins in Early Pregnancy and Pregnancy-Associated Pathologies

Galectins are a family of conserved soluble proteins defined by an affinity for β-galactoside structures present on various glycoconjugates. Over the past few decades, galectins have been recognized as important factors for successful implantation and maintenance of pregnancy. An increasing number of studies have demonstrated their involvement in trophoblast cell function and placental development. In addition, several lines of evidence suggest their important roles in feto-maternal immune tolerance regulation and angiogenesis. Changed or dysregulated galectin expression is also described in pregnancy-related disorders. Although the data regarding galectins’ clinical relevance are still at an early stage, evidence suggests that some galectin family members are promising candidates for better understanding pregnancy-related pathologies, as well as predicting biomarkers. In this review, we aim to summarize current knowledge of galectins in early pregnancy as well as in pregnancy-related pathologies.